Effects of magnesium sulphate on coagulation after laparoscopic colorectal cancer surgery, measured by rotational thromboelastometry (ROTEM^®)

Abstract

SummaryWe investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in patients undergoing laparoscopic colorectal cancer surgery. Patients were randomly allocated to the magnesium group (n = 22) or control group (n = 22). The magnesium group received intravenous magnesium sulphate (50 mg.kg We conclude that ROTEM analysis demonstrated that intra-operative administration of intravenous magnesium sulphate reduces blood hypercoagulability in patients undergoing laparoscopic colorectal cancer surgery.

Magnesium Sulfate Treatment During Total Knee Arthroplasty Decreases Postoperative Urinary Retention: A Retrospective Propensity Score-Matched Analysis

“…The incidence of hypomagnesemia was reported to be 19% before cardiac operations, to peak to 71% after surgery, and to subside to 66% at 24 h postoperatively [30]. Through previous clinical trials, our magnesium treatment regimen resulted in increased postoperative magnesium concentrations up to 1.3-1.6 mM without any detectable complications of hypermagnesemia, and the increased concentration returned to normal level within postoperative day 1-3 [23,28]. Fortunately, this level of magnesium concentration helps with postoperative urination, according to our results.…”

“…However, these preclinical results were obvious with high concentrations of magnesium ions (5 mM) or with accompanying low concentrations of calcium ions (0.6 mM). Magnesium is normally obtained only through diet, and following a major surgery, the serum magnesium levels readily decrease [28,29]. The incidence of hypomagnesemia was reported to be 19% before cardiac operations, to peak to 71% after surgery, and to subside to 66% at 24 h postoperatively [30].…”

Coagulation profile after plasma exchange using albumin as a replacement solution measured by thromboelastometry

“…The basic principle of the TEM can account for the disagreement . No significant variations were seen in pH, ionic Ca and blood cellular components after PE; in spite of that, TEM is performed in whole blood and several variables that are relevant during the PE, that is changes in blood viscosity due to albumin, magnesium, hemodilution and patient condition can affect the results. Because of this, TEM could offer information beyond the standard coagulation test, detecting patients at highest risk of bleeding after PE.…”

A reply

“…In their well-conducted, randomised controlled study comparing two techniques of i-gel placement, Kim et al demonstrated that, compared with the standard technique, i-gel insertion using the rotational technique results in an increased firstattempt insertion success rate, a shorter insertion time, a better airway seal and less pharyngeal mucosal trauma [1]. We would like to ask the authors several questions about their study.…”