Effects of magnetic nanoparticles on mixing in droplet-based microfluidics

Maleki, Mohammad Amin; Soltani, M.; Kashaninejad, Navid; Nguyen, Nam‐Trung

doi:10.1063/1.5086867

Cited by 50 publications

(22 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…indicate that the uniform magnetic field enhances spreading. Under a uniform magnetic field, a magnetic force acts at the fluids interface due to the concentration gradient of the magnetic particles and the consequent magnetisation gradient (Maleki et al 2019). Magnetic particles migrate from the high concentration to the low concentration, e.g.…”

Section: Validation Of the Numerical Simulation With The Experimental Resultsmentioning

confidence: 99%

Magnetofluidic spreading in circular chambers under a uniform magnetic field

Maleki

Zhang

Kashaninejad

et al. 2020

Microfluid Nanofluid

Self Cite

View full text Add to dashboard Cite

Elucidating the microscale interaction between magnetism and fluid flow is of great importance for designing micro-magnetofluidic gradient generators, micromixers, and particle sorters. Coflowing magnetic and non-magnetic fluids can lead to instability at their interface and subsequent rapid mixing. The mismatch in the magnetisation of the fluids leads to instabilities. The present study systematically investigates the magnetofluidic spreading phenomena of both magnetic nanoparticles and non-magnetic fluorescent dye in consecutive circular chambers. Numerical simulations and experimental investigations were conducted to thoroughly evaluate the physics of magnetofluidic spreading. We show that the presence of the consecutive chambers can enhance magnetofluidic spreading by slowing down the flow and increasing the mass transfer rate transversal to the flow direction. The numerical results reveal that the magnetic force, induced by the magnetic susceptibility gradient, generates cross-sectional secondary flows that steer particles toward both the top and bottom walls. The induced secondary flow also enhances the transport of fluorescent dye, thereby leading to a higher mass transfer rate as compared to pure molecular 2 diffusion. The findings provide further insights into the microscale spreading phenomenon of magnetic and non-magnetic particles in a magnetic field.

show abstract

Section: Validation Of the Numerical Simulation With The Experimental Resultsmentioning

confidence: 99%

Magnetofluidic spreading in circular chambers under a uniform magnetic field

Maleki

Zhang

Kashaninejad

et al. 2020

Microfluid Nanofluid

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the most recent years, MNPs have been utilized in numerous bioanalysis, extending from manual measures for essential research to tests in high-throughput instruments for incorporated labs [96][97][98]. The development of microsystem for the movement of NPs within microchannels is controlled by an external magnetic field that needs microfabricated components perfect with prevailing magnetic-based bioassays and gives an appealing option in contrast to standard techniques for analyte control and infusion [99]. The availability of MNPs and corresponding analyzing reagents along with miniaturization technologies have formed a starting point for magnetic-based μTAS and LOC systems [100].…”

Section: Magnetic Nanoparticle-based Microfluidicsmentioning

confidence: 99%

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

et al. 2020

View full text Add to dashboard Cite

Superparamagnetic nanoparticles are attracting significant attention. Therefore, being explored in microsystems for a wide range of applications. Typical examples include labon-a-chip and microfluidics for synthesis, detection, separation, and transportation of different bioanalytes, such as biomolecules, cells, and viruses to develop portable, sensitive, and cost-effective biosensing systems. Particularly, microfluidic systems incorporated with magnetic nanoparticles and, in combination with magnetoresistive sensors, shift diagnostic and analytical methods to a microscale level. In this context, nanotechnology enables the miniaturization and integration of a variety of analytical functions in a single chip for manipulation, detection, and recognition of bioanalytes reliably and flexibly. In consideration of the above, recent development and benefits are elaborated herein to discuss the role of magnetic nanoparticles inside the microchannels to design highly efficient disposable point-of-care applications from transportation to the detection of bioanalytes.

show abstract

“…Alternatively, microfluidic technology can address the limitations associated with conventional ISF sampling techniques. Microfluidics is an emerging science and technology that can offer significant improvements over various fields, including surface science [15], porous systems [16], nanotechnology for disease diagnosis [17], mixing [18], and separation [19,20], mechanobiology [21], cancer research [22,23], cell culture [24,25], single-cell analysis [26], drug delivery at cellular [27] and tissue levels [28], electrochemical biosensing [29], and POC sensing [30]. Furthermore, the emerging field of micro elastofluidics can provide microfluidic solutions for a flexible, conformal system attached to the skin [27].…”

Section: Introductionmentioning

confidence: 99%

Microneedle Arrays for Sampling and Sensing Skin Interstitial Fluid

et al. 2021

Self Cite

View full text Add to dashboard Cite

Dermal interstitial fluid (ISF) is a novel source of biomarkers that can be considered as an alternative to blood sampling for disease diagnosis and treatment. Nevertheless, in vivo extraction and analysis of ISF are challenging. On the other hand, microneedle (MN) technology can address most of the challenges associated with dermal ISF extraction and is well suited for long-term, continuous ISF monitoring as well as in situ detection. In this review, we first briefly summarise the different dermal ISF collection methods and compare them with MN methods. Next, we elaborate on the design considerations and biocompatibility of MNs. Subsequently, the fabrication technologies of various MNs used for dermal ISF extraction, including solid MNs, hollow MNs, porous MNs, and hydrogel MNs, are thoroughly explained. In addition, different sensing mechanisms of ISF detection are discussed in detail. Subsequently, we identify the challenges and propose the possible solutions associated with ISF extraction. A detailed investigation is provided for the transport and sampling mechanism of ISF in vivo. Also, the current in vitro skin model integrated with the MN arrays is discussed. Finally, future directions to develop a point-of-care (POC) device to sample ISF are proposed.

show abstract

Effects of magnetic nanoparticles on mixing in droplet-based microfluidics

Cited by 50 publications

References 58 publications

Magnetofluidic spreading in circular chambers under a uniform magnetic field

Magnetofluidic spreading in circular chambers under a uniform magnetic field

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

Microneedle Arrays for Sampling and Sensing Skin Interstitial Fluid

Contact Info

Product

Resources

About