The current analysis concentrated on the consequence of Casson dissipative fluid and spanwise consinusoidally fluctuation temperature on unsteady magnetohydrodynamics free convective flow past a moving hot vertical permeable plate with heat generation, radiation absorption, and chemical reaction. It has imperative practical applications in plentiful fields like physiological processes, biomedical science, food processing, pharmaceutical, chemical material processing engineering, manufacturing systems, and so on. The governing partial differential equations are evaluated analytically by employing a multiple regular perturbation method. The influence of assortment physical estimators on fluid velocity, temperature, concentration, skin friction, Nusselt number, and Sherwood number was illustrated quantitatively through graphs. Eventually, it was revealed that velocity, concentration, and Sherwood number declined with the progressive values of the chemical reaction parameter. Velocity and temperature were enhanced with incremental values of Prandtl number, while the contradictory impact occurred in Nusselt number and skin friction. Meanwhile, velocity and skin friction lessened with the incremental values of the magnetic parameter and Casson fluid parameter.