Effects of magnolol on egg production, egg quality, antioxidant capacity, and intestinal health of laying hens in the late phase of the laying cycle

Chen, Fang; Zhang, Hao; Du, Encun; Jin, Feng; Zheng, Chao; Fan, Qi-Wen; Zhao, Ning; Guo, Wenjing; Zhang, Wei; Huang, Shaowen; Wei, Jintao

doi:10.1016/j.psj.2020.10.047

Cited by 44 publications

(41 citation statements)

References 38 publications

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“…Consistent with these reports, S. pullorum infections significantly reduced villus height in the jejunum and ileum, and this adverse effect lasted until at least 21 days of age. In our previous study, we confirmed that magnolol could increase the intestinal villus height of laying hens [ 23 ]. Magnolol has also been shown to improve the intestinal mucosal status of Linwu ducks [ 24 ].…”

Section: Discussionsupporting

confidence: 75%

Supplemental magnolol or honokiol attenuates adverse effects in broilers infected with Salmonella pullorum by modulating mucosal gene expression and the gut microbiota

Chen

Zhang

et al. 2021

J Animal Sci Biotechnol

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Background Salmonella pullorum is one of the most harmful pathogens to avian species. Magnolol and honokiol, natural compounds extracted from Magnolia officinalis, exerts anti-inflammatory, anti-oxidant and antibacterial activities. This study was conducted to evaluate the effects of dietary supplemental magnolol and honokiol in broilers infected with S. pullorum. A total of 360 one-day-old broilers were selected and randomly divided into four groups with six replicates: the negative control group (CTL), S. pullorum-infected group (SP), and the S. pullorum-infected group supplemented with 300 mg/kg honokiol (SPH) or magnolol (SPM). Results The results showed that challenging with S. pullorum impaired growth performance in broilers, as indicated by the observed decreases in body weight (P < 0.05) and average daily gains (P < 0.05), along with increased spleen (P < 0.01) and bursa of Fabricus weights (P < 0.05), serum globulin contents, and the decreased intestine villus height and villus/crypt ratios (P < 0.05). Notably, supplemental magnolol and honokiol attenuated these adverse changes, and the effects of magnolol were better than those of honokiol. Therefore, we performed RNA-Seq in ileum tissues and 16S rRNA gene sequencing of ileum bacteria. Our analysis revealed that magnolol increased the α-diversity (observed species, Chao1, ACE, and PD whole tree) and β-diversity of the ileum bacteria (P < 0.05). In addition, magnolol supplementation increased the abundance of Lactobacillus (P < 0.01) and decreased unidentified Cyanobacteria (P < 0.05) both at d 14 and d 21. Further study confirmed that differentially expressed genes induced by magnolol and honokiol supplementation enriched in cytokine-cytokine receptor interactions, in the intestinal immune network for IgA production, and in the cell adhesion molecule pathways. Conclusions Supplemental magnolol and honokiol alleviated S. pullorum-induced impairments in growth performance, and the effect of magnolol was better than that of honokiol, which could be partially due to magnolol’s ability to improve the intestinal microbial and mucosal barrier.

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Section: Discussionsupporting

confidence: 75%

Supplemental magnolol or honokiol attenuates adverse effects in broilers infected with Salmonella pullorum by modulating mucosal gene expression and the gut microbiota

Chen

Zhang

et al. 2021

J Animal Sci Biotechnol

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“…The morphology of the villi and crypts of the intestinal mucosa are essential indicators of intestinal health (Chen et al 2021). The longer the villus height and the shallower the crypt depth in the small intestine, the greater the ability to absorb nutrients.…”

Section: Discussionmentioning

confidence: 99%

Effects of coated sodium butyrate on production performance, egg quality, serum biochemistry, digestive enzyme activity, and intestinal health of laying hens

Miao

Zhou

et al. 2021

Italian Journal of Animal Science

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The present study was conducted to investigate the effects of coated sodium butyrate (CSB) on production performance, egg quality, serum biochemistry, digestive enzyme activity, intestinal health of laying hens. 720 hens at 52 weeks were assigned in five groups including basal diet (control) and a basal diet supplemented with 250, 500, 750, and 1000 mg/kg CSB for 8 weeks. The results showed that the 500 mg/kg CSB group increased laying rate but 500 and 750 mg/kg groups decreased feed conversion ratio (p < .05). At the fourth week, dietary CSB at more than or equal to 500 mg/kg level increased the Haugh unit (p < .01); At the eighth week, 500 and 1000 mg/kg CSB groups improved the eggshell strength, Haught unit and albumen height (p < .05). Dietary CSB administration except for the 250 mg/kg group increased the serum albumin and calcium and decreased the triglyceride content (p < .05). 500 and 750 mg/kg CSB groups increased the activities of trypsin and amylase in the pancreas and duodenum (p < .05). The groups of 500 and 750 mg/kg increased the villus height and villus height to crypt depth ratio (V/C) in the jejunum and ileum (p < .05). In the jejunum, at more than or equal to 500 mg/ kg CSB groups increased the expressions of ZO-1 and Occludin (p < .05); In the ileum, 500 and 750 mg/kg CSB groups increased the expressions of claudin-1 and occludin and ZO-2 (p < .05). Conclusively, dietary supplementation of CSB can improve egg production, egg quality, digestive enzyme activity and present a positive effect on improving villi and intestinal mechanical barrier function. HIGHLIGHTSA significant improvement in production performance and egg quality was observed in birds fed diet with coated sodium butyrate. Administration of coated sodium butyrate enhanced protein and mineral availability and lipid metabolism of serum. Supplementation of coated sodium butyrate presented a positive impact on regulating intestinal health.

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“…Even though magnolol was studied in animal models including mice [21] and laying hens [22], the effects of magnolol on ducks were rarely reported. Linwu duck, a major indigenous breed of ducks in China, were used in the present study.…”

Section: Introductionmentioning

confidence: 99%

Magnolol additive improves growth performance of Linwu ducklings by modulating antioxidative status

et al. 2021

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Magnolol is a bioactive polyphenolic compound commonly found in Magnolia officinalis. The aim of this study is to clarify the contribution of the magnolol additive on the growth performance of Linwu ducklings aging from 7 to 28 d, comparing to the effects of antibiotic additive (colistin sulphate). A total of 325, 7-d-old ducklings were assigned to 5 groups. Each group had 5 cages with 13 ducklings in each cage. The ducklings in different groups were fed with diets supplemented with 0, 100, 200 and 300 mg/kg magnolol additive (MA) (Control, MA100, MA200 and MA300) and 30 mg/kg colistin sulphate (CS30) for 3 weeks, respectively. Parameters regarding to the growth performance, intestinal mucosal morphology, serum biochemical indices, antioxidant and peroxide biomarkers and the expression levels of antioxidant-related genes were evaluated by one way ANOVA analysis. The results showed that 30 mg/kg colistin sulphate, 200 and 300 mg/kg magnolol additive improved the average final weight (P = 0.045), average daily body weight gain (P = 0.038) and feed/gain ratios (P = 0.001) compared to the control group. 200 and 300 mg/kg magnolol additive significantly increased the villus height/crypt depth ratio of ileum, compared to the control and CS30 groups (P = 0.001). Increased serum level of glucose (P = 0.011) and total protein (P = 0.006) were found in MA200 or MA300 group. In addition, comparing to the control and CS30 groups, MA200 or MA300 significantly increased the levels of superoxide dismutase (P = 0.038), glutathione peroxidase (P = 0.048) and reduced glutathione (P = 0.039) in serum. Moreover, the serum and hepatic levels of 8-hydroxy-2’-deoxyguanosine (P = 0.043 and 0.007, respectively) were lower in all MA groups compared to those of the control and CS30 group. The hepatic mRNA expression levels of superoxide dismutase-1, catalase and nuclear factor erythroid-2-related factor 2/erythroid-derived CNC-homology factor were also increased significantly in MA200 and MA300 groups (P < 0.05). Taken together, these data demonstrated that MA was an effective feed additive enhancing the growth performance of Linwu ducklings at 7 to 28 d by improving the antioxidant and intestinal mucosal status. It suggested that MA could be a potential ingredient to replace the colistin sulphate in diets.

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Effects of magnolol on egg production, egg quality, antioxidant capacity, and intestinal health of laying hens in the late phase of the laying cycle

Cited by 44 publications

References 38 publications

Supplemental magnolol or honokiol attenuates adverse effects in broilers infected with Salmonella pullorum by modulating mucosal gene expression and the gut microbiota

Supplemental magnolol or honokiol attenuates adverse effects in broilers infected with Salmonella pullorum by modulating mucosal gene expression and the gut microbiota

Effects of coated sodium butyrate on production performance, egg quality, serum biochemistry, digestive enzyme activity, and intestinal health of laying hens

Magnolol additive improves growth performance of Linwu ducklings by modulating antioxidative status

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