Effects of major adipokines and the −420 C &gt; G resistin gene polymorphism on the long-term outcome of patients with acute ischemic stroke

Bouziana, Stella D.; Τζιόμαλος, Κωνσταντίνος; Goulas, A.; Vyzantiadis, Timoleon‐Achilleas; Papadopoulou, Maria; Panderi, Athanasia; Ηatzitolios, Apostolos Ι.

doi:10.1080/00207454.2019.1596906

Cited by 7 publications

(4 citation statements)

References 43 publications

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“…Resistin is a proinflammatory adipokine, which promotes insulin resistance (197) and atherosclerosis (182,198,199). Elevated resistin level is associated with an increased risk of ischemic stroke (199)(200)(201)(202)(203)(204). Resistin was shown to increase permeability in a cell culture-based blood-brain barrier model (205).…”

Section: Altered Adipokine Secretionmentioning

confidence: 99%

Obesity-induced cognitive impairment in older adults: a microvascular perspective

Balasubramanian

Kiss

Tarantini

et al. 2021

American Journal of Physiology-Heart and Circulatory Physiology

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Over two thirds of individuals aged 65 and older are obese or overweight in the United States. Epidemiological data show an association between the degree of adiposity and cognitive dysfunction in the elderly. In this review, the pathophysiological roles of microvascular mechanisms, including impaired endothelial function and neurovascular coupling responses, microvascular rarefaction and blood-brain barrier disruption in the genesis of cognitive impairment in geriatric obesity are considered. The potential contribution of adipose-derived factors and fundamental cellular and molecular mechanisms of senescence to exacerbated obesity-induced cerebromicrovascular impairment and cognitive decline in aging are discussed.

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Section: Altered Adipokine Secretionmentioning

confidence: 99%

Obesity-induced cognitive impairment in older adults: a microvascular perspective

Balasubramanian

Kiss

Tarantini

et al. 2021

American Journal of Physiology-Heart and Circulatory Physiology

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“…One of the most frequently studied polymorphisms, C to G substitution at -420 position in the 5' flanking region of the gene showed altered resistin gene expression (mRNA levels) in abdominal fat with increased serum resistin level (35). This polymorphism has independently been associated with cardiovascular risk factors, such as insulin resistance, type 2 diabetes mellitus (T2DM), obesity, hypertension, dyslipidemia, and metabolic syndrome, as well as with coronary heart disease (arteriosclerosis, coronary artery disease, idiopathic dilated cardiomyopathy) (36)(37)(38)(39). In a meta-analysis, G allele of Resistin-420 C/G polymorphism was reported as a risk factor for obesity (40).…”

Section: Discussionmentioning

confidence: 99%

Effects of Leptin, Resistin, and <i>PPAR</i>-Gama Gene Variants on Obese Patients with Acute Coronary Syndrome in the Turkish Population

Arat¹,

Yılmaz²,

Yilmaz³

et al. 2020

jarem

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Objective: Obesity and acute coronary syndrome (ACS) are common health problems of recent years. There are many candidate genes related to the genetic infrastructure of ACS and obesity. This study aimed to investigate the association of Leptin glutamine to arginine substitution (Gln223Arg), Resistin-420 Cytosine/Guanine (C/G), and proliferator-activated receptor-gamma (PPAR-γ) proline to alanine substitution (Pro12Ala) polymorphisms in obese patients with ACS in the Turkish population. Methods: Fifty obese patients concurrently diagnosed with ACS and 42 healthy controls were included in this study. These polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism and agarose gel electrophoresis methods. Results: The PPAR-γ Pro12Ala polymorphism Pro/Ala genotype (p=0.001) was found to be higher in the obese patients with ACS, while the (Proline/ Proline) genotype (p=0.001) was significantly higher in the control group. The GC genotype (p=0.045) distribution of Resistin-420 C/G was found to be significantly higher in the controls compared to the patient group. Conclusion: Our study presents new findings that the PPAR-γ Pro12Ala polymorphism Pro/Ala genotype is a risk factor for ACS in obese individuals, whereas Resistin-420 C/G polymorphism GC genotype and PPAR-γ Pro12Ala polymorphism Pro/Pro genotype may be protective factors for ACS in obese individuals.

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“…Interestingly, the same group also found an association between -420G and improved 1-year mRS scores. The authors postulate the contradiction stems from selection bias whereby -420G carriers who endure increased risk of acute death may create artificial associations with long-term recovery [ 29 ].…”

Section: Inflammationmentioning

confidence: 99%

Genetics of ischemic stroke functional outcome

Carnwath,

Demel,

Prestigiacomo

2024

J Neurol

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Ischemic stroke, which accounts for 87% of cerebrovascular accidents, is responsible for massive global burden both in terms of economic cost and personal hardship. Many stroke survivors face long-term disability—a phenotype associated with an increasing number of genetic variants. While clinical variables such as stroke severity greatly impact recovery, genetic polymorphisms linked to functional outcome may offer physicians a unique opportunity to deliver personalized care based on their patient’s genetic makeup, leading to improved outcomes. A comprehensive catalogue of the variants at play is required for such an approach. In this review, we compile and describe the polymorphisms associated with outcome scores such as modified Rankin Scale and Barthel Index. Our search identified 74 known genetic polymorphisms spread across 48 features associated with various poststroke disability metrics. The known variants span diverse biological systems and are related to inflammation, vascular homeostasis, growth factors, metabolism, the p53 regulatory pathway, and mitochondrial variation. Understanding how these variants influence functional outcome may be helpful in maximizing poststroke recovery.

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Effects of major adipokines and the −420 C > G resistin gene polymorphism on the long-term outcome of patients with acute ischemic stroke

Cited by 7 publications

References 43 publications

Obesity-induced cognitive impairment in older adults: a microvascular perspective

Obesity-induced cognitive impairment in older adults: a microvascular perspective

Effects of Leptin, Resistin, and <i>PPAR</i>-Gama Gene Variants on Obese Patients with Acute Coronary Syndrome in the Turkish Population

Genetics of ischemic stroke functional outcome

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