Effects of Major Depressive Disorder on Monocytes, High-Density Lipoprotein (Hdl) and Monocyte to HDL Ratio: A Case-Control Study

Uyar, Betül; Budak, Elif Ateş

doi:10.24869/psyd.2022.687

Cited by 7 publications

(3 citation statements)

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“…Some scholars found the relevance of this class of inflammatory markers to psychiatric disorders. Such inflammatory markers have also been correlated with depressive disorders [ 35 , 36 ]. In 2021, Sahpolat et al first found significant differences in the MHR between patients with schizophrenia and healthy populations in a small sample study [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia

Cheng

Zhang

et al. 2023

Medicina

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Background and Objectives: Schizophrenia with aggression often has an inflammatory abnormality. The monocyte/high-density lipoprotein ratio (MHR), neutrophil/high-density lipoprotein ratio (NHR), platelet/high-density lipoprotein ratio (PHR) and lymphocyte/high-density lipoprotein ratio (LHR) have lately been examined as novel markers for the inflammatory response. The objective of this study was to assess the relationship between these new inflammatory biomarkers and aggression in schizophrenia patients. Materials and Methods: We enrolled 214 schizophrenia inpatients in our cross-sectional analysis. They were divided into the aggressive group (n = 94) and the non-aggressive group (n = 120) according to the Modified Overt Aggression Scale (MOAS). The severity of schizophrenia was assessed using the Positive and Negative Syndrome Scale (PANSS). The numbers of platelets (PLT), neutrophils (NEU), lymphocytes (LYM), monocytes (MON) and the high-density lipoprotein (HDL) content from subjects were recorded. The NHR, PHR, MHR and LHR were calculated. We analyzed the differences between those indexes in these two groups, and further searched for the correlation between inflammatory markers and aggression. Results: Patients with aggression had higher positive symptom scores (p = 0.002). The values of PLT, MON, MHR and PHR in the aggressive group were considerably higher (p < 0.05). The NHR (r = 0.289, p < 0.01), LHR (r = 0.213, p < 0.05) and MHR (r = 0.238, p < 0.05) values of aggressive schizophrenia patients were positively correlated with the total weighted scores of the MOAS. A higher MHR (β = 1.529, OR = 4.616, p = 0.026) and positive symptom scores (β = 0.071, OR = 1.047, p = 0.007) were significant predictors of aggression in schizophrenia patients. Conclusions: The MHR and the positive symptom scores may be predictors of aggressive behavior in schizophrenia patients. The MHR, a cheap and simple test, may be useful as a clinical tool for risk stratification, and it may direct doctors’ prevention and treatment plans in the course of ordinary clinical care.

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Section: Introductionmentioning

confidence: 99%

The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia

Cheng

Zhang

et al. 2023

Medicina

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“…High SII values are associated with disease severity and poor prognosis in many diseases and malignancies [ 11 , 14 , 17 ]. Patients with major depressive disorder have a high monocyte/HDL ratio which elevates as the severity of depression increases [ 36 ]. Recently, the use of SII has been expanded to include psychiatric disorders.…”

Section: Discussionmentioning

confidence: 99%

“…11,14,17 Patients with major depressive disorder have a high monocyte/HDL ratio which elevates as the severity of depression increases. 36 Recently, the use of SII has been expanded to include psychiatric disorders. SII is elevated mainly in men who express manic episodes and women accompanying depressive episodes.…”

Section: Discussionmentioning

confidence: 99%

Methamphetamine Use Disorder and Inflammation: A Case-Control Study

Gürbüzer,

Güler,

Tör

2024

Psychiatry Investig

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Objective Methamphetamine use disorder (MUD) is a global health condition that impairs a person’s health which may result in morbidity and mortality. Inflammation is a crucial process playing a vital role in MUD. For this reason, it is necessary to examine biochemical parameters for follow-up and treatment alternatives.Methods We aimed to reveal the relationship between inflammatory response and MUD by evaluating peripheral hemogram parameters, leukocyte count, subtypes, and their ratios to each other, systemic immune inflammation index (SII), monocyte/high-density lipoprotein (HDL) ratio, and human C-reactive protein (CRP) in adult men with MUD. We included 76 adult male participants in the patient group and 70 adult male participants in the control group. We calculated the neutrophil/lymphocyte rate (NLR), monocyte/lymphocyte rate (MLR), platelet/lymphocyte rate (PLR), and basophil/lymphocyte rate (BLR). In addition, we obtained the SII and the monocyte/HDL rate.Results The patients’ leukocyte (p<0.001), platelet (p<0.001), plateletcrit (PCT) (p=0.002), neutrophil (p<0.001), monocyte (p=0.002), CRP (p<0.001), NLR (p=0.001), PLR (p=0.004), MLR (p=0.009), SII (p<0.001) and monocyte/HDL ratio (p<0.001) were higher than the control group. We observed a significant and positive relationship between the daily methamphetamine intake, and methamphetamine use duration (p=0.002), PCT (p=0.044), neutrophil (p=0.021), NLR (p=0.001), PLR (p=0.004), MLR (p=0.029), and SII (p<0.001). Daily methamphetamine intake had a significant and positive effect on SII. A one-unit increase in daily methamphetamine intake elevated SII by 165.53 units.Conclusion The results confirm the presence of peripheral subclinical inflammation and systemic immune inflammation in adult men with MUD.

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Peripheral blood cellular immunophenotype in suicidal ideation, suicide attempt, and suicide: a systematic review and meta-analysis

Daray,

Chiapella,

Grendas

et al. 2024

Mol Psychiatry

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Effects of Major Depressive Disorder on Monocytes, High-Density Lipoprotein (Hdl) and Monocyte to HDL Ratio: A Case-Control Study

Cited by 7 publications

References 0 publications

The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia

The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia

Methamphetamine Use Disorder and Inflammation: A Case-Control Study

Peripheral blood cellular immunophenotype in suicidal ideation, suicide attempt, and suicide: a systematic review and meta-analysis

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