Effects of male social status on reproductive success and on behavior in mice (Mus musculus).

D’Amato, Francesca R.

doi:10.1037/0735-7036.102.2.146

Cited by 47 publications

(24 citation statements)

References 22 publications

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“…Also, because the males in the first experiment were housed in groups of four until two or three days prior to restricted female access, many of males used in this study were likely of subordinate social status. Previous research suggests that if a subordinate male is cohabitated with a dominant male, the subordinate male decreases investigation and sexual interaction with a female as the period of cohabitation increases, despite the fact that the dominant male is not present for these interactions [25]. Differences in reproductive success between subordinate and dominant males were observed to become negligible after one to three weeks of single-housing [25].…”

Section: Discussionmentioning

confidence: 91%

“…Previous research suggests that if a subordinate male is cohabitated with a dominant male, the subordinate male decreases investigation and sexual interaction with a female as the period of cohabitation increases, despite the fact that the dominant male is not present for these interactions [25]. Differences in reproductive success between subordinate and dominant males were observed to become negligible after one to three weeks of single-housing [25]. For restricted social interaction experiment #2, the males were not housed with other males for at least nine days prior to the restricted female access.…”

Section: Discussionmentioning

confidence: 99%

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Daily Timed Sexual Interaction Induces Moderate Anticipatory Activity in Mice

et al. 2010

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Anticipation of resource availability is a vital skill yet it is poorly understood in terms of neuronal circuitry. Rodents display robust anticipatory activity in the several hours preceding timed daily access to food when access is limited to a short temporal duration. We tested whether this anticipatory behavior could be generalized to timed daily social interaction by examining if singly housed male mice could anticipate either a daily novel female or a familiar female. We observed that anticipatory activity was moderate under both conditions, although both a novel female partner and sexual experience are moderate contributing factors to increasing anticipatory activity. In contrast, restricted access to running wheels did not produce any anticipatory activity, suggesting that an increase in activity during the scheduled access time was not sufficient to induce anticipation. To tease apart social versus sexual interaction, we tested the effect of exposing singly housed female mice to a familiar companion female mouse daily. The female mice did not show anticipatory activity for restricted female access, despite a large amount of social interaction, suggesting that daily timed social interaction between mice of the same gender is insufficient to induce anticipatory activity. Our study demonstrates that male mice will show anticipatory activity, albeit inconsistently, for a daily timed sexual encounter.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Daily Timed Sexual Interaction Induces Moderate Anticipatory Activity in Mice

et al. 2010

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“…Second, it is possible an increase in androgen receptor expression increases mate preference and/or increases the probability of copulation for dominant animals. Sexual behavior and dominance status are closely associated in males, with dominant animals showing increased sexual behavior in a variety of species (Blanchard and Blanchard, 1989; D’Amato, 1988; Dewsbury, 1988; Perret, 1992; Perret, 1977). Interestingly, female Syrian hamsters prefer dominant males over subordinates in a mate choice test (Brown et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

Winning agonistic encounters increases testosterone and androgen receptor expression in Syrian hamsters

Clinard

Barnes

Adler

et al. 2016

Hormones and Behavior

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Winning aggressive disputes is one of several experiences that can alter responses to future stressful events. We have previously tested dominant and subordinate male Syrian hamsters in a conditioned defeat model and found that dominant individuals show less change in behavior following social defeat stress compared to subordinates and controls, indicating a reduced conditioned defeat response. Resistance to the effects of social defeat in dominants is experience-dependent and requires the maintenance of dominance relationships for 14 days. For this study we investigated whether winning aggressive interactions increases plasma testosterone and whether repeatedly winning increases androgen receptor expression. First, male hamsters were paired in daily 10-min aggressive encounters and blood samples were collected immediately before and 15-min and 30-min after the formation of dominance relationships. Dominants showed an increase in plasma testosterone at 15-min post-interaction compared to their pre-interaction baseline, whereas subordinates and controls showed no change in plasma testosterone. Secondly, we investigated whether 14 days of dominant social status increased androgen or estrogen alpha-receptor immunoreactivity in brain regions that regulate the conditioned defeat response. Dominants showed more androgen, but not estrogen alpha, receptor immuno-positive cells in the dorsal medial amygdala (dMeA) and ventral lateral septum (vLS) compared to subordinates and controls. Finally, we showed that one day of dominant social status was insufficient to increase androgen receptor immunoreactivity compared to subordinates. These results suggest that elevated testosterone signaling at androgen receptors in the dMeA and vLS might contribute to the reduced conditioned defeat response exhibited by dominant hamsters.

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“…Socially-defeated animals interact less with unfamiliar animals (Frischknecht et al, 1982; Kudryavtseva et al, 1991; Kudryavtseva, 1994; Meerlo, Overkamp, Daan, et al, 1996; Huhman et al, 2003), engage in few reproductive activities (Kahn, 1961; D'Amato, 1988; Blanchard&Blanchard, 1989;Yoshimura&Kimura, 1991; Foxet al, 1997) and readily display defensive and submissive postures and vocal signals (Van de Poll et al, 1982; Siegfried et al, 1984; Puglisi-Allegra & Cabib, 1988; van der Poel & Miczek, 1991; Potegal et al, 1993). In general, defeated animals are less active, and explore, forage, eat and drink less (Raab et al, 1986; Meerlo, Overkamp, Benning, et al, 1996; Meerlo, Overkamp, Daan et al, 1996; Flügge et al, 1998).…”

Section: Which Types Of Social Stress?mentioning

confidence: 99%

Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake

Miczek

Yap

Covington

2008

Pharmacology & Therapeutics

295

252

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The impact of ostensibly aversive social stresses on triggering, amplifying and prolonging intensely rewarding drug taking is an apparent contradiction in need of resolution. Social stress encompasses various types of significant life events ranging from maternal separation stress, brief episodes of social confrontations in adolescence and adulthood, to continuous subordination stress, each with its own behavioral and physiological profile. The neural circuit comprising the VTA–accumbens–PFC–amygdala is activated by brief episodes of social stress, which is critical for the DA-mediated behavioral sensitization and increased stimulant consumption. A second neural circuit comprising the raphe–PFC–hippocampus is activated by continuous subordination stress and other types of uncontrollable stress. In terms of the development of therapeutics, brief maternal separation stress has proven useful in characterizing compounds acting on subtypes of GABA, glutamate, serotonin and opioid receptors with anxiolytic potential. While large increases in alcohol and cocaine intake during adulthood have been seen after prolonged maternal separation experiences during the first two weeks of rodent life, these effects may be modulated by additional yet to be identified factors. Brief episodes of defeat stress can engender behavioral sensitization that is relevant to escalated and prolonged self-administration of stimulants and possibly opioids, whereas continuous subordination stress leads to anhedonia-like effects. Understanding the intracellular cascade of events for the transition from episodic to continuous social stress in infancy and adulthood may provide insight into the modulation of basic reward processes that are critical for addictive and affective disorders.

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Effects of male social status on reproductive success and on behavior in mice (Mus musculus).

Cited by 47 publications

References 22 publications

Daily Timed Sexual Interaction Induces Moderate Anticipatory Activity in Mice

Daily Timed Sexual Interaction Induces Moderate Anticipatory Activity in Mice

Winning agonistic encounters increases testosterone and androgen receptor expression in Syrian hamsters

Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake

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