Effects of Mandibular Advancement on Growth after Condylectomy

Nakano, Masami; Fujita, Tadashi; Ohtani, Junji; Kawata, Toshitsugu; Kaku, Masato; Motokawa, Masaharu; Tsuka, Natsumi; Hayashi, Hidetaka; Tanne, Kazuo

doi:10.1177/0022034508329671

Cited by 14 publications

(17 citation statements)

References 21 publications

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“…For example, a unilateral condylectomy in rats reduced growth of the mandible and a subsequent lateral shift to the affected side, but the reduced growth and the lateral shift of the mandible were eliminated by a functional appliance, and prominent regeneration of the condyle also occurred. 24 These are not adopted in human condyle. Thus, caution should be exercised when the present findings are applied to humans.…”

Section: Discussionmentioning

confidence: 99%

Functional adaptability of temporomandibular joint mechanoreceptors after an increase in the occlusal vertical dimension in rats

Naito¹,

Ishida²,

Kokai³

et al. 2011

The Angle Orthodontist

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Objective: To investigate the effects of an experimentally-induced increase in the occlusal vertical dimension (iOVD) on the functional characteristics of temporomandibular joint (TMJ) mechanoreceptors in rats. Materials and Methods: Sixty 13-week-old male albino Wistar rats were divided into control and iOVD groups (30 animals each). The vertical dimension between the maxillary and mandibular molars in the iOVD group was increased by 2.0 mm with a build-up of resin on the maxillary molars. Single-unit activities of TMJ mechanoreceptors were evoked by passive jaw movement. Recording was performed from the gasserian ganglion 1 day and 1, 3, 5, 7, and 9 weeks after the establishment of iOVD. Results: Compared with the control group, the firing threshold was significantly lower at 1, 3, and 5 weeks after iOVD in the iOVD group. There were no significant differences in the firing threshold at 1 day, or 7 or 9 weeks. The maximum instantaneous firing frequency was significantly higher at 1, 3, and 5 weeks after iOVD in the iOVD group, but there were no significant differences at 1 day, or 7 or 9 weeks. There were no significant differences in the average firing frequency during the experimental period. Conclusions: The present study findings suggest that TMJ mechanoreceptors in adult rats may ultimately adapt to iOVD. (Angle Orthod. 2011;81:453-459.)

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Section: Discussionmentioning

confidence: 99%

Functional adaptability of temporomandibular joint mechanoreceptors after an increase in the occlusal vertical dimension in rats

Naito¹,

Ishida²,

Kokai³

et al. 2011

The Angle Orthodontist

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“…The animal model used in this study has already been described elsewhere (8). Forty‐five 3‐wk‐old C57BL/6J mice (Jackson Laboratory, Bar Harbor, ME, USA) were placed into one of the following groups ( n = 15 mice per group): the condylectomy group, the condylectomy + appliance group, and the sham‐operated control group.…”

Section: Methodsmentioning

confidence: 99%

“…In a recent study, it was demonstrated that mandibular growth is inhibited in growing mice that have undergone a condylectomy. However, the reduced growth was shown to be counteracted by means of a functional appliance used to reposition the mandible forward in a symmetric position (8). From those results, it is apparent that the mandibular condyle plays an important role in the control of mandibular growth and that the growth increase stimulated by the use of the functional appliance could compensate for the reduced growth and the lateral shift of the mandible following unilateral condylectomy.…”

mentioning

confidence: 99%

“…From those results, it is apparent that the mandibular condyle plays an important role in the control of mandibular growth and that the growth increase stimulated by the use of the functional appliance could compensate for the reduced growth and the lateral shift of the mandible following unilateral condylectomy. Moreover, it is of great interest that the appliance induces the regeneration of the condyle, even after the condylectomy (8).…”

mentioning

confidence: 99%

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Changes in cortical bone mineralization in the mouse mandible with regenerated condyle

Fujita

Ohtani

Shirakura

et al. 2011

European Journal of Oral Sciences

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The objective of this study was to evaluate the effects of condylectomy and of a functional appliance on the mineral content, density, and area of the mandibular cortical bone in a growing mouse model. In the condylectomy group, a unilateral condylectomy was performed on the right side of the mouse mandible. In the condylectomy + appliance group, a functional appliance was used to reposition the mandible after the unilateral condylectomy. All mice were killed 4 wk after surgery. Each mandible was then subjected to analyses of cortical bone mineral content (CRT_CNT), cortical bone density (CRT_DEN), and cortical bone area (CRT_A) by peripheral quantitative computed tomography (pQCT). The CRT_CNT, CRT_DEN, and CRT_A values were significantly lower in the condylectomized mandible (right side) than in the non-condylectomized mandible (left side). However, in the condylectomized animals in which a functional appliance was used, the CRT_CNT, CRT_DEN, and CRT_A values became higher than those in the mice treated with condylectomy alone. No significant differences were found in the CRT_CNT, CRT_DEN, and CRT_A between non-condylectomized (left side) mandibles, mandibles treated with condylectomy + functional appliance (right side), and control mandibles. It was thus shown that a functional appliance used to reposition the condylectomized mandible forward in a symmetric position induced improvement of the cortical bone in a mouse model in terms of cortical bone mineral content, density, and area.

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“…A partir do quinto mês fetal o centro de crescimento do côndilo mandibular será responsável pelo alongamento da mandíbula durante os primeiros 10 anos de vida pós-natal (Garcia & Fernández, 2001 e revisto em Serrano et al, 2011). A importância do côndilo nesse período é reforçada pela observação de lesões no côndilo em camundongos com 3 semanas de idade, as quais resultam na redução do crescimento condilar e mandibular, levando à assimetria da mandíbula e deslocamento lateral (Nakano et al, 2009).…”

Section: Desenvolvimento Embrionáriounclassified

Identificação de novas variantes causativas e investigação da heterogeneidade clínica da Síndrome aurículo-condilar

Tavares¹

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RESUMOConsiderada uma doença de primeiro e segundo arcos faríngeos (FaSPAD), a Síndrome Aurículo-Condilar (ACS) apresenta como principais características micrognatia, malformação auricular típica chamada de question mark ear (QME) e hipoplasia do côndilo mandibular. Variabilidade clínica inter e intrafamiliar, bem como heterogeneidade genética são observadas na ACS. A doença segrega tanto de maneira autossômica dominante quanto recessiva. Variantes patogênicas tem sido identificadas em GNAI3, PLCB4 e EDN1 como responsáveis pela maioria dos casos investigados.Ainda, estudos não publicados do nosso grupo sugerem a ocorrência de um quarto locus EDN1 in the majority of the investigated cases. Furthermore, non-published studies of our group indicate a fourth locus associated with ACS. In the present study, our aim was to identify the causative variants of ACS in previously and not reported cases and also to investigate the clinical heterogeneity of ACS. We identified pathogenic variants in PLCB4 and GNAI3 in 5 out of 6 ACS cases. In the remaining case (1∕6), we narrow down the fourth candidate region to contain causative variant of ACS. Additional studies are being conducted to identify it. We also hypothesized that all GNAI3 variants, herein and previously described, interfere with the GDP∕GTP binding, acting through a dominant negative mechanism. Furthermore, we found additional clinical findings in patients with ACS and PLCB4 variants.

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Effects of Mandibular Advancement on Growth after Condylectomy

Cited by 14 publications

References 21 publications

Functional adaptability of temporomandibular joint mechanoreceptors after an increase in the occlusal vertical dimension in rats

Functional adaptability of temporomandibular joint mechanoreceptors after an increase in the occlusal vertical dimension in rats

Changes in cortical bone mineralization in the mouse mandible with regenerated condyle

Identificação de novas variantes causativas e investigação da heterogeneidade clínica da Síndrome aurículo-condilar

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