Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells

Fang, Yuanyuan; Gan, Cui-liu; Peng, Jianchao; Xie, Yuhan; Song, Han-Xiao; Yang, Mingxiao; Ou, Shiyan; Aschner, Michael; Jiang, Yue-Ming

doi:10.1007/s12011-023-03792-z

Cited by 4 publications

(1 citation statement)

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“…Iron induces the activation of BV2 microglia; the increase in reactive oxygen species; and the activation of cytokines, TNF-a, and IL-1B. This is accompanied by a decrease in the potential of mitochondrial membranes and an increase in the activity of proteins related to apoptosis such as Bcl2, BAx, P53, and caspase 9 [29]. Excess iron induces a loss of cognitive functions and loss of synaptic proteins that is attenuated by ferrostatin-1, a ferroptosis inhibitor, and z-VAD-FMK, a pan-caspase inhibitor [30].…”

Section: Iron Toxicitymentioning

confidence: 99%

On the Role of Iron in Idiopathic Parkinson’s Disease

Huenchuguala,

Segura-Aguilar

2023

Biomedicines

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The transition metal characteristics of iron allow it to play a fundamental role in several essential aspects of human life such as the transport of oxygen through hemoglobin or the transport of electrons in the mitochondrial respiratory chain coupled to the synthesis of ATP. However, an excess or deficiency of iron is related to certain pathologies. The maintenance of iron homeostasis is essential to avoid certain pathologies related to iron excess or deficiency. The existence of iron deposits in postmortem tissues of Parkinson’s patients has been interpreted as evidence that iron plays a fundamental role in the degenerative process of the nigrostriatal system in this disease. The use of iron chelators has been successful in the treatment of diseases such as transfusion-dependent thalassemia and pantothenate kinase-associated neurodegeneration. However, a clinical study with the iron chelator deferiprone in patients with Parkinson’s disease has not shown positive effects but rather worsened clinical symptoms. This suggests that iron may not play a role in the degenerative process of Parkinson’s disease.

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Section: Iron Toxicitymentioning

confidence: 99%