Effects of Mangifera indica (Careless) on Microcirculation and Glucose Metabolism in Healthy Volunteers

Buchwald-Werner, Sybille; Schön, Christiane; Frank, S.; Reule, Claudia

doi:10.1055/s-0043-103017

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…Finally, the number of subjects enrolled was comparable to that reported in other studies evaluating the role of cocoa, chocolate and mango in the modulation of endothelial function through PAT technology. [23][24][25][26] Results…”

Section: Discussionmentioning

confidence: 99%

A serving of blueberry (V. corymbosum) acutely improves peripheral arterial dysfunction in young smokers and non-smokers: two randomized, controlled, crossover pilot studies

et al. 2017

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Several studies have documented the important role of polyphenol-rich foods in the modulation of vascular remodelling and function. This study aimed to evaluate the capacity of a single portion of blueberry (V. corymbosum) to acutely improve peripheral arterial dysfunction in a group of young volunteers. Twenty-four healthy males (12 non-smokers and 12 smokers) were recruited for two different randomized, controlled, crossover pilot acute studies. In the first study, non-smokers were exposed to a control treatment (C; 300 mL of water with sugar) and a blueberry treatment (BB; 300 g of blueberry). In the second study, smokers underwent 3 different protocols: (1) - smoking treatment (S); (2) - control treatment (CS; 300 mL of water with sugar + smoking); (3) - blueberry treatment (BS; 300 g of blueberry + smoking). Each treatment (1 day long) was separated by a one week washout period. Blood pressure, peripheral arterial function (reactive hyperemia index, RHI, a marker of endothelial function) and arterial stiffness (digital augmentation index, dAix and dAix normalized by considering a heart rate of 75 bpm, dAix@75) were measured before and after each treatment. In the first study, the consumption of blueberry and control treatment acutely increased peripheral arterial function in the group of non-smokers. The improvement in RHI was higher and significantly different after blueberry treatment compared to the control treatment (54.8 ± 8.4% BB vs. 28.2 ± 8.3% C; p = 0.01). No effects were observed for markers of arterial stiffness, blood pressure and heart rate. Acute cigarette smoke significantly increased blood pressure and heart rate, while no significant effect was registered in peripheral arterial function and stiffness. The intake of blueberry and control treatment before a cigarette did not counteract the increase in blood pressure and heart rate, while it significantly improved peripheral arterial function. In particular, a significant increase was observed following BS (35.2 ± 7.5% RHI; p = 0.02) and CS treatments (34.6 ± 11.9% RHI; p = 0.02) when compared to only smoking treatment. No difference between BS and CS was detected. In conclusion, the intake of blueberry and control treatments acutely improved peripheral arterial dysfunction both in smoker and in non-smoker subjects. Further studies should be performed to confirm the results obtained and reveal the potential mechanisms of blueberry in the improvement of endothelial function.

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Section: Discussionmentioning

confidence: 99%

A serving of blueberry (V. corymbosum) acutely improves peripheral arterial dysfunction in young smokers and non-smokers: two randomized, controlled, crossover pilot studies

et al. 2017

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“…In a human pilot study, a powder supplement containing 100% Mangifera indica L. fruit improved microcirculation by potentiating the reactive hyperemia response, an effect which was attributed to the increase in eNOS expression, as observed in endothelial cells in vitro [200]. Another study showed that the same extract was able to improve reactive hyperemia evoked in the postprandial state after a high glucose intake, a factor known to impair the endothelium [201]. To our knowledge, no adverse effects related to Mangifera indica L. intake have been reported.…”

Section: Mangifera Indica Lmentioning

confidence: 93%

The Role of Food Supplementation in Microcirculation—A Comprehensive Review

Raposo

Saraiva

Ramos

et al. 2021

Biology

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(1) Background: Cardiovascular disease (CVD) is a major public health concern worldwide and a key cause of morbidity and mortality in developed countries. Accumulating evidence shows that several CVD forms are characterized by significant microcirculatory dysfunction, which may both cause and be caused by macrovascular disease, often preceding clinical manifestations by several years. Therefore, interest in exploring food supplements to prevent and restore microcirculation has grown. Given the continuous need to expand the available therapeutic arsenal for CVD, the food supplements market has recently grown and is expected to continue growing. (2) Methods: We provide an authoritative up-to-date comprehensive review of the impact of food supplementation on microcirculation by analyzing the European and American legal food supplements framework and the importance of food safety/food quality in this industry. We review the main literature about food bioactive compounds with a focus on microcirculation and some main food supplements with proven benefits. (3) Results: Despite a lack of scientific evidence, diet and microcirculatory function are clearly connected. The main food supplement examples in the literature with potential beneficial effects on microcirculation are: Ruscus aculeatus, Centella asiatica, Ginkgo biloba, Salvia miltiorrhiza, Crataegus spp., Ginseng, Mangifera indica, Aesculus hipocastanum, Hamamelis virginiana, and Vitis vinifera. (4) Conclusions: Further clinical trials are necessary to better explore the effects of these food supplements, particularly on humans.

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“…Buchwald-Werner et al [43] conducted a study investigating the long-term consumption of a commercial powdered M. indica product (Careless™) on microcirculation and glucose metabolism. The researchers deemed these findings promising, indicating a modest beneficial effect of M. indica fruit preparation on microcirculation, endothelial function, and glucose metabolism by the end of the study.…”

Section: Indica and Health Effects: Results From Clinical Trialsmentioning

confidence: 99%

Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review

Minniti,

Laurindo,

Machado

et al. 2023

Life

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Mango and its by-products have traditional medicinal uses. They contain diverse bioactive compounds offering numerous health benefits, including cardioprotective and metabolic properties. This study aimed to explore the impact of mango fruit and its by-products on human health, emphasizing its metabolic syndrome components. PUBMED, EMBASE, COCHRANE, and GOOGLE SCHOLAR were searched following PRISMA guidelines, and the COCHRANE handbook was utilized to assess bias risks. In vivo and in vitro studies have shown several benefits of mango and its by-products. For this systematic review, 13 studies met the inclusion criteria. The collective findings indicated that the utilization of mango in various forms—ranging from fresh mango slices and mango puree to mango by-products, mango leaf extract, fruit powder, and mangiferin—yielded many favorable effects. These encompassed enhancements in glycemic control and improvements in plasma lipid profiles. Additionally, mango reduces food intake, elevates mood scores, augments physical performance during exercise, improves endothelial function, and decreases the incidence of respiratory tract infections. Utilizing mango by-products supports the demand for healthier products. This approach also aids in environmental conservation. Furthermore, the development of mango-derived nanomedicines aligns with sustainable goals and offers innovative solutions for healthcare challenges whilst being environmentally conscious.

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Effects of Mangifera indica (Careless) on Microcirculation and Glucose Metabolism in Healthy Volunteers

Cited by 7 publications

References 15 publications

A serving of blueberry (V. corymbosum) acutely improves peripheral arterial dysfunction in young smokers and non-smokers: two randomized, controlled, crossover pilot studies

A serving of blueberry (V. corymbosum) acutely improves peripheral arterial dysfunction in young smokers and non-smokers: two randomized, controlled, crossover pilot studies

The Role of Food Supplementation in Microcirculation—A Comprehensive Review

Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review

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