Effects of Mangifera indica L. aqueous extract (Vimang) on primary culture of rat hepatocytes

Rodeiro, Idania; Donato, M. Teresa; Jiménez, Núria; Garrido, Gabino; Delgado, René; Gómez-Lechón, Marı́a José

doi:10.1016/j.fct.2007.05.027

Cited by 28 publications

(17 citation statements)

References 32 publications

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“…In a previous study using rat hepatocytes, we observed that MSBE reduces oxidations catalysed by CYP1A2, without affecting other P450s (Rodeiro et al, 2007). With HLM, we corroborated previous findings on CYP1A and 2D enzymes, but not on CYP3A.…”

Section: Resultssupporting

confidence: 93%

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Inhibition of human P450 enzymes by natural extracts used in traditional medicine

Rodeiro¹,

Donato

Jiménez

et al. 2008

Phytotherapy Research

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Different medicinal plants are widely used in Cuba and Mexico to treat several disorders. This paper reports in vitro inhibitory effects on the P450 system of herbal products commonly used by people in Cuba and Mexico in traditional medicine for decades. Experiments were conducted in human liver microsomes. The catalytic activities of CYP1A1/2, 2D6, and 3A4 were measured using specific probe substrates. The Heliopsis longipes extract exhibited a concentration-dependent inhibition of the three enzymes, and similar effects were produced by affinin (an alkamide isolated from the H. longipes extract) and two catalytically reduced alkamides. Mangifera indica L. and Thalassia testudinum extracts, two natural polyphenol-rich extracts, diminished CYP1A1/2 and 3A4 activities, but not the CYP2D6 activity. These results suggest that these herbs inhibit the major human P450 enzymes involved in drug metabolism and could induce potential herbal-drug interactions.

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Section: Resultssupporting

confidence: 93%

“…(Rodeiro et al, 2007). This apparent discrepancy could be due to different catalytic properties of rat CYP3A1 and human CYP3A4, and/or to differences in the metabolism of MSBE components in both species.…”

Section: Acknowledgementsmentioning

confidence: 86%

Inhibition of human P450 enzymes by natural extracts used in traditional medicine

Rodeiro¹,

Donato

Jiménez

et al. 2008

Phytotherapy Research

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“…Manga-Espada and manga-Rosa are the most commonly varieties cultivated in the Pernambuco state, Brazil, where their leaves are used in folk medicine to treat backaches and bronchitis [1]. Previous investigations of the biological properties of M. indica have found that this plant has antiviral, antibacterial, analgesic, anti-inflammatory, immunomodulatory, and antioxidant activities [2, 3]. The composition of the essential oils of M. indica fruits, including the Espada and Rosa varieties, has been extensively investigated [4–12], but, to our knowledge, this is the first report on the volatile components of latex from M. indica var.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils fromMangifera indicaL. var. Rosa and Espada

Ramos

Moraes

Nerys

et al. 2014

BioMed Research International

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The essential oils from Mangifera indica var. Rosa and Espada latex were obtained by hydrodistillation and analyzed using GC-FID and GC-MS. Twenty-seven components were identified. The main compound in the essential oil from M. indica var. Espada (EOMiE) was terpinolene (73.6%). The essential oil of M. indica var. Rosa (EOMiR) was characterized by high amounts of β-pinene (40.7%) and terpinolene (28.3%). In the test for leishmanicidal activity against promastigotes forms of L. amazonensis, EOMiR and EOMiE showed IC50 (72 h) of 39.1 and 23.0 μg/mL, respectively. In macrophages, EOMiR and EOMiE showed CC50 of 142.84 and 158.65 μg/mL, respectively. However, both were more specific to the parasite than macrophages, with values of selectivity index of 6.91 for EOMiE and 3.66 for EOMiR. The essential oils were evaluated for their cytotoxicity against the human tumor cells HEp-2, HT-29, NCI-H292, and HL-60. The EOMiR and EOMiE were most effective against the HL-60, with IC50 values of 12.3 and 3.6 μg/mL, respectively. The results demonstrated that the essential oils of M. indica can destroy L. amazonensis and inhibit tumor cell growth. These findings contribute to the knowledge of the Brazilian biodiversity as a source of potential therapeutic agents.

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“…In particular, the MSBE antioxidant capacity, ROS scavenging ability and consequent protection have been verified in several models of oxidative damage both in vitro and in vivo and in different organs and tissues Rodeiro et al, 2007Rodeiro et al, , 2008PardoAndreu et al, 2008;Martinez-Sanchez et al, 2000. Since arsenic is generally believed to induce cell damage by triggering cellular events, such as ROS production, leading to oxidative stress (Lantz & Hays, 2006), we may hypothesize that MSBE, behaving as a strong antioxidant, could suppress these events.…”

Section: Discussionmentioning

confidence: 99%

Polyphenols of Mangifera indica modulate arsenite-induced cytotoxicity in a human proximal tubule cell line

Garrido¹,

Romiti²,

Tramonti³

et al. 2012

Rev. bras. farmacogn.

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Inorganic arsenic is an ubiquitous environmental contaminant able to cause severe pathologies in humans, including kidney disorders. The possible protective effects of Mangifera indica L., Anacardiaceae, stem bark extract (MSBE) and some mango phenols on the cytotoxicity of arsenite (As III ) in the proximal tubule cell line HK-2 was investigated. In cells cultured for 24 h in presence of As III , a dose-dependent loss of cell viability occurred that was signifi cantly alleviated by MSBE, followed by gallic acid, catechin and mangiferin. Mangiferin complexed with Fe +++ proved more effi cacious than mangiferin alone. MSBE and pure phenols increased signifi cantly the cell surviving fraction in clonogenic assays. In cells pretreated with MSBE or phenols for 72 h the protection afforded by MSBE resulted decreased in comparison with the shorter experiments. Cells pretreated with a subcytotoxic amount of As III or cultured in continuous presence of low concentration of mangiferin proved to be more resistant to As III , while cells cultured in presence of albumin resulted more sensitive. Because all the above conditions share changes in expression/activity of P-glycoprotein (P-gp), a transporter potentially involved in arsenic resistance, the capability of M. indica phenols in modulating As III -induced cytotoxicity would be at least in part dependent on their interactions with P-gp.

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Effects of Mangifera indica L. aqueous extract (Vimang) on primary culture of rat hepatocytes

Cited by 28 publications

References 32 publications

Inhibition of human P450 enzymes by natural extracts used in traditional medicine

Inhibition of human P450 enzymes by natural extracts used in traditional medicine

Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils fromMangifera indicaL. var. Rosa and Espada

Polyphenols of Mangifera indica modulate arsenite-induced cytotoxicity in a human proximal tubule cell line

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