Effects of Mannooligosaccharides from Coffee Mannan on Fat Storage in Mice Fed a High Fat Diet

Takao, Izumi; Fujii, Shigeyoshi; Ishii, Asako; Han, Li; Kumao, Toshio; Ozaki, Kazuto; Asakawa, Atsushi

doi:10.1248/jhs.52.333

Cited by 23 publications

(24 citation statements)

References 7 publications

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“…The active ingredients [16][17] have significant effects on visceral fat area as well as body fat, but the mechanisms of body fat loss induced by the ingestion of various foods vary with ingredients. FOSHU has not been allowed the body-fat health claim on fiber ingredients such as β-glucan.…”

Section: Discussionmentioning

confidence: 99%

Effect of High β-Glucan Barley on Serum Cholesterol Concentrations and Visceral Fat Area in Japanese Men—A Randomized, Double-blinded, Placebo-controlled Trial

Shimizu

Kihara

Aoe

et al. 2007

Plant Foods Hum Nutr

126

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This study investigated whether the consumption of a diet in which high-beta-glucan barley replaced rice would reduce the visceral fat area as well as the serum low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) in hypercholesterolemic Japanese men. A randomized, double-blinded, placebo-controlled intervention study was conducted in 44 hypercholesterolemic Japanese men with a body mass index (BMI) >22 kg/m2. The subjects were randomly assigned to groups consuming either rice (placebo group) or a mixture of rice and pearl barley with a high beta-glucan content (test group, 7.0 g beta-glucan per day) for 12 weeks. Blood samples were taken, and CT scan obtained before the trial and every four weeks during the trial. The pearl barley intake significantly reduced serum concentrations of LDL-C (P = 0.041) and TC (P = 0.037) during the trial. Significant differences between the test and placebo groups were found for the visceral fat (P = 0.039), BMI (P = 0.015), and waist circumference (P = 0.011) at the end point. The consumption of pearl barley with a high beta-glucan content reduces not only LDL-C but also visceral fat area.

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Section: Discussionmentioning

confidence: 99%

Effect of High β-Glucan Barley on Serum Cholesterol Concentrations and Visceral Fat Area in Japanese Men—A Randomized, Double-blinded, Placebo-controlled Trial

Shimizu

Kihara

Aoe

et al. 2007

Plant Foods Hum Nutr

126

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“…MOS possesses antioxidant, anti‐inflammatory, and antidiabetic bioactivities . MOS supplementation has been found to reduce body weight and visceral fat weight in high‐fat diet (HFD)‐induced obese mice . Human clinical research also indicated that MOS treatment decreased fat absorption .…”

Section: Introductionmentioning

confidence: 99%

Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western‐Diet‐Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short‐Chain Fatty Acids Production

Yan

Shi

et al. 2019

Molecular Nutrition Food Res

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Scope Obesity is associated with gut microbiome dysbiosis. Mannose oligosaccharide (MOS) has been reported to be a potential prebiotic. The present study is aimed to determine the effects of MOS on western‐diet‐induced obesity and to uncover the mediating roles of the gut microbiota and microbial metabolites. Methods and results Three‐month‐old male ICR mice are fed with a high‐fat and high‐fructose diet for 8 weeks. The diet‐induced obese mice are then orally administrated with MOS (100 and 200 mg kg–1 d–1) for 4 weeks. MOS significantly reduces bodyweight gain, insulin resistance, fatty liver, and inflammatory responses in obese mice. MOS also stimulates lipolysis and inhibits lipogenesis in the adipose tissues. Moreover, MOS restructures the gut microbiome by enhancing the abundance of Bifidobacterium and Lactobacillus in obese mice. The microbial metabolite SCFAs are also increased in the feces and serum. Correlation analysis indicates that the appetite suppression and lipid‐lowering effects of MOS are highly correlated with the butyrate levels. Conclusion MOS suppresses the appetite, which results in less lipid deposition. The lower appetite is likely due to an altered gut microbiome and elevated SCFAs production. MOS may be a potential nutraceutical used in body weight management and gut health improvement.

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“…Mannans may prevent fat storage through inhibiting the intestinal absorption of dietary fat in high fat diets (Takao et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Effects of konjac glucomannan hydrolysates on the gut microflora of mice

Elamir

Tester

Al‐Ghazzewi

et al. 2008

Nutrition &Amp; Food Science

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Purpose - The aim of this study is to determine the effects of depolymerised mannans and specifically konjac glucomannan hydrolysates (GMH) on the colonic microflora of mice. Blood glucose and cholesterol were also measured. Design/methodology/approach - Two groups (n?=?20) of 12-week old Wister mice were used for a period of 14 weeks. One group (treatment group) were fed diets containing 5 per cent konjac GMH dissolved in drinking water in addition to the control (group) standard diet. Faecal microflora, feed consumption, body weight, blood glucose and cholesterol were determined. Findings - The GMH promoted the growth of anaerobes and lactobacilli in the treatment group where this was statistically, highly significant (P?

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Effects of Mannooligosaccharides from Coffee Mannan on Fat Storage in Mice Fed a High Fat Diet

Cited by 23 publications

References 7 publications

Effect of High β-Glucan Barley on Serum Cholesterol Concentrations and Visceral Fat Area in Japanese Men—A Randomized, Double-blinded, Placebo-controlled Trial

Effect of High β-Glucan Barley on Serum Cholesterol Concentrations and Visceral Fat Area in Japanese Men—A Randomized, Double-blinded, Placebo-controlled Trial

Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western‐Diet‐Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short‐Chain Fatty Acids Production

Effects of konjac glucomannan hydrolysates on the gut microflora of mice

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