Effects of Matcha Green Tea Powder on Cognitive Functions of Community-Dwelling Elderly Individuals

Sakurai, Keisuke; Shen, Chutong; Ezaki, Yuri; Inamura, Noriko; Fukushima, Yoichi; Masuoka, Nobutaka; Hisatsune, Tatsuhiro

doi:10.3390/nu12123639

Cited by 29 publications

(30 citation statements)

References 91 publications

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“…Six food-based intervention studies were conducted on cognitively healthy participants. In a parallel intervention study carried out in 61 subjects over 60 years, the con-sumption of 3 g/d of matcha green tea powder for 12 weeks improved cognitive and memory function [32]. Similarly, daily avocado consumption (140-175 g/d) for 3 months ameliorated attentional inhibition in 47 young adults [33].…”

Section: Food-based Interventions (N = 7)mentioning

confidence: 99%

Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

et al. 2021

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New dietary approaches for the prevention of cognitive impairment are being investigated. However, evidence from dietary interventions is mainly from food and nutrient supplement interventions, with inconsistent results and high heterogeneity between trials. We conducted a comprehensive systematic search of randomized controlled trials (RCTs) published in MEDLINE-PubMed, from January 2018 to July 2021, investigating the impact of dietary counseling, as well as food-based and dietary supplement interventions on cognitive function in adults with or without cognitive impairment. Based on the search strategy, 197 eligible publications were used for data abstraction. Finally, 61 articles were included in the analysis. There was reasonable evidence that dietary patterns, as well as food and dietary supplements improved cognitive domains or measures of brain integrity. The Mediterranean diet showed promising results, whereas the role of the DASH diet was not clear. Healthy food consumption improved cognitive function, although the quality of these studies was relatively low. The role of dietary supplements was mixed, with strong evidence of the benefits of polyphenols and combinations of nutrients, but with low evidence for PUFAs, vitamin D, specific protein, amino acids, and other types of supplements. Further well-designed RCTs are needed to guide the development of dietary approaches for the prevention of cognitive impairment.

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Section: Food-based Interventions (N = 7)mentioning

confidence: 99%

Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

et al. 2021

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“…Moreover, Sakurai et al assessed the effect of three grams of powder from fresh matcha for 12 weeks administered to an elderly population without dementia or with MCI; no significant differences were seen in cognitive, memory and impulsivity tests. However, when only women were analyzed, differences were obtained between the matcha and placebo sub-groups with the Montreal cognitive assessment (MoCA) tool [ 116 ]. Similarly, a study by Baba et al included volunteers between 50–69 years with self-assessed cognitive decline (MMSE > 24 score) who were given green tea catechin capsules (336.4 mg) or placebo on a daily basis for 12 weeks; significant improvement on working memory tasks were observed in the group who received green tea, evaluated with the Cognitrax battery of tests.…”

Section: Resultsmentioning

confidence: 99%

“…To date, there are no studies in humans reproducing the encouraging results obtained with the use of EGCG in animal models. Human research has been carried out with different types of green tea extracts at different proportions of many catechins, and mild improvements have been seen in certain areas of cognition or population subgroups [ 5 , 115 , 116 ]. Thus, prevention or improvement of cognitive decline remains uncertain, requiring more evidence to determine which populations and areas can be improved with catechin supplementation.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Catechins in Less Common Neurological and Neurodegenerative Disorders

et al. 2021

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In recent years, neurological and neurodegenerative disorders research has focused on altered molecular mechanisms in search of potential pharmacological targets, e.g., imbalances in mechanisms of response to oxidative stress, inflammation, apoptosis, autophagy, proliferation, differentiation, migration, and neuronal plasticity, which occur in less common neurological and neurodegenerative pathologies (Huntington disease, multiple sclerosis, fetal alcohol spectrum disorders, and Down syndrome). Here, we assess the effects of different catechins (particularly of epigalocatechin-3-gallate, EGCG) on these disorders, as well as their use in attenuating age-related cognitive decline in healthy individuals. Antioxidant and free radical scavenging properties of EGCG -due to their phenolic hydroxyl groups-, as well as its immunomodulatory, neuritogenic, and autophagic characteristics, makes this catechin a promising tool against neuroinflammation and microglia activation, common in these pathologies. Although EGCG promotes the inhibition of protein aggregation in experimental Huntington disease studies and improves the clinical severity in multiple sclerosis in animal models, its efficacy in humans remains controversial. EGCG may normalize DYRK1A (involved in neural plasticity) overproduction in Down syndrome, improving behavioral and neural phenotypes. In neurological pathologies caused by environmental agents, such as FASD, EGCG enhances antioxidant defense and regulates placental angiogenesis and neurodevelopmental processes. As demonstrated in animal models, catechins attenuate age-related cognitive decline, which results in improvements in long-term outcomes and working memory, reduction of hippocampal neuroinflammation, and enhancement of neuronal plasticity; however, further studies are needed. Catechins are valuable compounds for treating and preventing certain neurodegenerative and neurological diseases of genetic and environmental origin. However, the use of different doses of green tea extracts and EGCG makes it difficult to reach consistent conclusions for different populations.

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“…The effect of imidazole dipeptides in elderly volunteers with normal cognitive function was detected by the WMS-DR test [ 22 , 23 , 24 , 25 ], and the results of MMSE supported the beneficial effect of the imidazole dipeptides on the preservation of cognitive function in individuals with MCI [ 16 , 26 , 46 ] and patients with probable AD [ 81 ]. Besides, MoCA (Montreal Cognitive Assessment) has been also been reported to be sensitive for detecting mild levels of cognitive impairment in elderly individuals [ 96 , 97 , 98 ], and in a recent study, to evaluate the effect of Matcha green tea formula on the preservation of cognitive function in women [ 98 ]. Both MoCa and WMS-DR appeared to be suitable tests to evaluate the effect of nutrients on cognition in elderly individuals whose cognitive function ranged between normality and MCI [ 99 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of Imidazole-Dipeptides on Cognitive Status and Preservation in Elders: A Narrative Review

Masuoka

Lei

et al. 2021

Nutrients

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The worldwide increase in the number of patients with dementia is becoming a growing problem, while Alzheimer’s disease (AD), a primary neurodegenerative disorder, accounts for more than 70% of all dementia cases. Research on the prevention or reduction of AD occurrence through food ingredients has been widely conducted. In particular, histidine-containing dipeptides, also known as imidazole dipeptides derived from meat, have received much attention. Imidazole dipeptides are abundant in meats such as poultry, fish, and pork. As evidenced by data from recent human intervention trials conducted worldwide, daily supplementation of carnosine and anserine, which are both imidazole dipeptides, can improve memory loss in the elderly and reduce the risk of developing AD. This article also summarizes the latest researches on the biochemical properties of imidazole dipeptides and their effects on animal models associated with age-related cognitive decline. In this review, we focus on the results of human intervention studies using supplements of poultry-derived imidazole dipeptides, including anserine and carnosine, affecting the preservation of cognitive function in the elderly, and discuss how imidazole dipeptides act in the brain to prevent age-related cognitive decline and the onset of dementia.

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Effects of Matcha Green Tea Powder on Cognitive Functions of Community-Dwelling Elderly Individuals

Cited by 29 publications

References 91 publications

Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

Therapeutic Effects of Catechins in Less Common Neurological and Neurodegenerative Disorders

Influence of Imidazole-Dipeptides on Cognitive Status and Preservation in Elders: A Narrative Review

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