Effects of maternal deprivation and environmental enrichment on anxiety-like and depression-like behaviors correlate with oxytocin system and CRH level in the medial-lateral habenula

Wei, Fengmei; Xian, Donghua; He, Yunqing; Yan, Ziqing; Deng, Xiao Yan; Chen, Yajie; Zhao, Long; Zhang, Yishu; Li, Wenhao; Ma, Bing‐Ji; Zhang, Junfeng; Jing, Yu‐Hong

doi:10.1016/j.peptides.2022.170882

Cited by 8 publications

(3 citation statements)

References 59 publications

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“…When the answer was 'yes', a score was given; when the answer was 'no' or 'not clear', no score was given. The overall scores for each article were calculated as a score of 0-10 points, with the quality of each study being classified as high (8)(9)(10), moderate (5)(6)(7), or low (<5). The two reviewers independently reviewed all the included studies.…”

Section: Methodological Quality Assessmentmentioning

confidence: 99%

Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review

Fernandes,

Lacerda,

Fidélis

et al. 2023

IJMS

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This systematic review aims to evaluate the influence of environmental enrichment (EE) on oncological factors in experimental studies involving various types of cancer models. A comprehensive search was conducted in three databases: PubMed (161 articles), Embase (335 articles), and Scopus (274 articles). Eligibility criteria were applied based on the PICOS strategy to minimize bias. Two independent researchers performed the searches, with a third participant resolving any discrepancies. The selected articles were analyzed, and data regarding sample characteristics and EE protocols were extracted. The outcomes focused solely on cancer and tumor-related parameters, including cancer type, description of the cancer model, angiogenesis, tumor occurrence, volume, weight, mice with tumors, and tumor inhibition rate. A total of 770 articles were identified across the three databases, with 12 studies meeting the inclusion criteria for this systematic review. The findings demonstrated that different EE protocols were effective in significantly reducing various aspects of tumor growth and development, such as angiogenesis, volume, weight, and the number of mice with tumors. Furthermore, EE enhanced the rate of tumor inhibition in mouse cancer models. This systematic review qualitatively demonstrates the impacts of EE protocols on multiple parameters associated with tumor growth and development, including angiogenesis, occurrence, volume, weight, and tumor incidence. Moreover, EE demonstrated the potential to increase the rate of tumor inhibition. These findings underscore the importance of EE as a valuable tool in the management of cancer.

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Section: Methodological Quality Assessmentmentioning

confidence: 99%

Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review

Fernandes,

Lacerda,

Fidélis

et al. 2023

IJMS

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show abstract

“…The neuroendocrine and neuronal changes mediated by neonatal maternal deprivation (MD) and postweaning environmental enrichment (EE) in females are strongly linked to anxiety and depression-like behaviors. Specifically, MD reduced the number of oxytocin (OT) immunoreactive neurons in the hypothalamic PVN and co-regulated the expression of CRH and oxytocin receptor (OTR) in the medial-lateral habenula (LHbM) [ 103 ]. Estrogen receptors are believed to play a significant role in regulating HPA axis function.…”

Section: Estrogen and Depressionmentioning

confidence: 99%

Role of estrogen in treatment of female depression

Sun,

Li,

Zhao

et al. 2024

Aging

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Depression is a neurological disorder that profoundly affects human physical and mental health, resulting in various changes in the central nervous system. Despite several prominent hypotheses, such as the monoaminergic theory, hypothalamic-pituitary-adrenal (HPA) axis theory, neuroinflammation, and neuroplasticity, the current understanding of depression’s pathogenesis remains incomplete. Importantly, depression is a gender-dimorphic disorder, with women exhibiting higher incidence rates than men. Given estrogen's pivotal role in the menstrual cycle, it is reasonable to postulate that its fluctuating levels could contribute to the pathogenesis of depression. Estrogen acts by binding to a diversity of receptors, which are widely distributed in the central nervous system. An abundance of research has established that estrogen and its receptors play a crucial role in depression, spanning pathogenesis and treatment. In this comprehensive review, we provide an in-depth analysis of the fundamental role of estrogen and its receptors in depression, with a focus on neuroinflammation, neuroendocrinology, and neuroplasticity. Furthermore, we discuss potential mechanisms underlying the therapeutic effects of estrogen in the treatment of depression, which may pave the way for new antidepressant drug development and alternative treatment options.

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“…Environmental Enrichment (EE) is an enhanced mental stimulation method that promotes stimuli developing memory-demanding tasks due to socio-environmental context where the rodents can interact actively with their complex surroundings [1,2]. In this context, EE has been investigated in animal studies and considers several disorders, such as Alzheimer's disease, Parkinson's disease, Stroke, and anxiety-like and depression-like behaviors [3][4][5]. Therefore, EE is known to delay the rate of progression and/or reduce the symptoms, and the severity of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Environmental Enrichment in Cancer: A Possible Tool to Combat Tumor Development: A Systematic Review

Fernandes,

Lacerda,

Fidelis

et al. 2023

Preprint

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Aims: This systematic review aims to evaluate the influence of Environmental Enrichment (EE) on oncological factors in experimental studies involving various types of cancer models. Methods: A comprehensive search was conducted in three databases: PubMed (161 articles), Embase (335 articles), and Scopus (274 articles). Eligibility criteria were applied based on the PICOS strategy to minimize bias. Two independent researchers performed the searches, with a third participant resolving any discrepancies. The selected articles were analyzed, and data regarding sample characteristics and EE protocols were extracted. The outcomes focused solely on cancer and tumor-related parameters, including cancer type, description of the cancer model, angiogenesis, tumor occurrence, volume, weight, mice with tumors, and tumor inhibition rate. Key-findings: A total of 770 articles were identified across the three databases, with 12 studies meeting the inclusion criteria for this systematic review. The findings demonstrated that different EE protocols were effective in significantly reducing various aspects of tumor growth and development, such as angiogenesis, volume, weight, and the number of mice with tumors. Furthermore, EE enhanced the rate of tumor inhibition in mouse cancer models. Findings: This systematic review highlights the significant impact of EE protocols on multiple parameters associated with tumor growth and development, including angiogenesis, occurrence, volume, weight, and tumor incidence. Moreover, EE demonstrated the potential to increase the rate of tumor inhibition. These findings underscore the importance of EE as a valuable tool in the management of cancer.

show abstract

Effects of maternal deprivation and environmental enrichment on anxiety-like and depression-like behaviors correlate with oxytocin system and CRH level in the medial-lateral habenula

Cited by 8 publications

References 59 publications

Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review

Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review

Role of estrogen in treatment of female depression

Environmental Enrichment in Cancer: A Possible Tool to Combat Tumor Development: A Systematic Review

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