Effects of Maternal Dodecanoic or Laurie Acid (C12:0) Feeding on Milk Fatty Acid Secretion and Lipogenesis in the Suckling Rat

Demarne, Y.; Epo, N.; Lecourtier, M.J.; Flanzy, J.

doi:10.1159/000241032

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…The main sources of milk lipids are dietary fat and fatty acids synthesized de nero by mammary glands (1)(2)(3)(4). Thus, maternal diet may influence the nutritional quality of fat available to the sucklings (5)(6)(7)(8). In this study, rat milk fatty acid composition was examined by gastric content analysis of 10-day-old suckling rats.…”

Section: Introductionmentioning

confidence: 99%

The effect of dietary fat on the fatty acid composition of lipids secreted in rats' milk

Brandorff

1980

Lipids

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During pregnancy and lactation, female rats were fed diets containing either 28% partially hydrogenated marine oil (28MO), 2% arachis oil (2AO), or no fat (FF). Milk lipid composition was examined by gas chromatographic analysis of the gastric content of 10-day-old suckling pups. An increase to 45% in the milk content of long chain monoenoic acids, 18:1, 20:1 and 22:1, reflects the fatty acid composition of the marine oil. Milk fatty acids of medium chain length comprised 6%, 31% and 24% of total fatty acids in the (28MO), (2AO) and (FF) groups, respectively, suggesting that a high-fat diet (28MO) inhibits the lipid synthetic activity of mammary glands. The amount of dienoic C18-acids (6%) in the group fed (28MO) containing no essential fatty acids (EFA) was similar to the amount of 18:2 in the group receiving a low-fat, EFA-rich diet (2AO). However, only half the dienoic acid from the milk of the (28MO)-fed animals was linoleic acid, which was most likely mobilized from fat depots.

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Section: Introductionmentioning

confidence: 99%

The effect of dietary fat on the fatty acid composition of lipids secreted in rats' milk

Brandorff

1980

Lipids

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Fatty acid composition of lipids in the maternal diet and establishment of a Lactobacillus sp. strain in the digestive tract of suckling gnotobiotic mice and rats

Lhuillery¹,

Demarne²,

Dubos³

et al. 1981

The American Journal of Clinical Nutrition

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Adult gnotobiotic mice and rats, monoassociated with a homofermentative strain of Lactobacillus sp. of intestinal origin, were fed either a commercial rodent chow A or a semisynthetic diet B. Similar numbers of lactobacilli were established in their gastrointestinal tract whatever diet they ate. The lactobacilli were established in the digestive tract of the newborn of A mothers at 2 days but were hardly established in mouse or rat pups of A mothers than in their mouse homologues. Comparative analysis of milk lipids in the A and B series showed a linoleic acid (18:2 n-6) content which was three times higher in the B than in the A series. Two diets S and H differing only by their lipid fractions, which, respectively, presented the same fatty acid compositions as lipids from diets A and B were then given to two others lots of Lactobacillus monoassociated mice. The establishment kinetics of the strain were the same in the mouse pups of these two lots precedently observed in the B series. The difference observed in the establishment kinetics of the Lactobacillus strain in the digestive tract of suckling gnotobiotic mice was thus attributed to other dietary factors than the fatty acid composition of the maternal diet.

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Ontogeny of intestinal nutrient transport

Thiesen¹,

Wild²,

Keelan³

et al. 2000

Rev. can. physiol. pharmacol.

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Children born prematurely lack the ability to digest and to absorb nutrients at rates compatible with their nutritional needs. As a result, total parenteral nutrition may need to be given. While this nutritional support may be lifesaving, the baby who receives this therapy is exposed to the risks of possible sepsis, catheter dysfunction, and liver disease. The rodent model of postnatal development provides a useful framework to investigate some of the cellular features of human intestinal development. The up-regulation of intestinal gene expression and precocious development of intestinal nutrient absorption can be achieved by providing growth factor(s) or by modifying the composition of the maternal diet during pregnancy and nursing or the weaning diet of the infant. Accelerating the digestive and absorptive functions of the intestine would thereby allow for the maintenance of infant nutrition through oral food intake, and might possibly eliminate the need for, and risks of, total parenteral nutrition. Accordingly, this review was undertaken to focus on the adaptive processes available to the intestine, to identify what might be the signals for and mechanisms of the modified nutrient absorption, and to speculate on approaches that need to be studied as means to possibly accelerate the adaptive processes in ways which would be beneficial to the newborn young.

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Effects of Maternal Dodecanoic or Laurie Acid (C12:0) Feeding on Milk Fatty Acid Secretion and Lipogenesis in the Suckling Rat

Cited by 4 publications

References 9 publications

The effect of dietary fat on the fatty acid composition of lipids secreted in rats' milk

The effect of dietary fat on the fatty acid composition of lipids secreted in rats' milk

Fatty acid composition of lipids in the maternal diet and establishment of a Lactobacillus sp. strain in the digestive tract of suckling gnotobiotic mice and rats

Ontogeny of intestinal nutrient transport

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