Effects of Maternal Ethanol Consumption on the Offspring Sensory‐Motor Development, Ultrasonic Vocalization, Audiogenic Immobility Reaction and Brain Monoamine Synthesis

Hård, Ernest; Engel, Jörgen A.; Larsson, Knut; Liljequist, Sture; Musi, Barbara

doi:10.1111/j.1600-0773.1985.tb01304.x

Cited by 21 publications

(1 citation statement)

References 46 publications

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“…Increased TH expression in the nucleus accumbens has been associated with significantly lower auditory and visual PPI in rats exposed to prenatal bacterial endotoxins [69] or prenatal turpentine [70]. Similarly, decreased synthesis of DA was observed in rat pups that were exposed to prenatal ethanol and had a subsequent 1–2 day delay in the development of the auditory startle response [71]. …”

Section: Discussionmentioning

confidence: 99%

Adolescent HIV-1 Transgenic Rats: Evidence for Dopaminergic Alterations in Behavior and Neurochemistry Revealed by Methamphetamine Challenge

Moran

Aksenov²,

Booze³

et al. 2012

CHR

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Since the introduction of combination antiretroviral therapy (cART) in the mid-90s, the most severe forms of HIV-1-associated neurocognitive disorders (HAND) have diminished. However, milder forms of HAND remain prevalent. Basic and clinical studies implicate alterations in the dopaminergic (DAergic) system in HIV-1 infection. We used the Fischer 344 HIV-1 transgenic (HIV-1 Tg) rat, which expresses 7 of the 9 HIV-1 genes, to examine potential DAergic alterations. Animals were studied beginning at 35 days of age to assess early-onset DAergic alterations, well before any documented neurological symptoms or clinical signs of “wasting”. At 48 hr intervals, animals were administered a single dose of methamphetamine (METH) (0, 0.5, 1, 2.5 and 5 mg/kg/ml s.c.) and tested for the auditory startle response (ASR) and prepulse inhibition (PPI), using an auditory prepulse [85dB(A) broad-band noise stimulus] and an auditory startle stimulus [100 dB(A) broad-band noise stimulus] in a sound-attenuating chamber with a continuous 70dB(A) white noise background. The protocol used a 5-min acclimation period, 6 startle trials, and 36 PPI trials [ISIs of 0, 8, 40, 80, 120, and 4000 ms, 6-trial blocks, Latin square design]. As the dose of METH increased, PPI of the startle response decreased. The HIV-1 Tg rats displayed a greater dose-dependency to the METH-induced disruption of PPI compared to non-transgenic controls. Western blot analysis of midbrain extracts revealed lower tyrosine hydroxylase (TH) protein levels and higher monoamine oxidase A (MAO-A) protein levels in HIV-1 Tg rats treated with METH compared to non-transgenic controls. Early-detected cognitive alterations in the preattentive process of sensorimotor gating may have significant predictive utility regarding the progression of DAergic alterations in HIV-1 infection.

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Section: Discussionmentioning

confidence: 99%

Adolescent HIV-1 Transgenic Rats: Evidence for Dopaminergic Alterations in Behavior and Neurochemistry Revealed by Methamphetamine Challenge

Moran

Aksenov²,

Booze³

et al. 2012

CHR

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Ethology and Neuropharmacology: Rodent Ultrasounds

Miczek

Tornatzky

Vivian

1991

Animal Models in Psychopharmacology

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Effects of chronic ethanol consumption on gestation and lactation in rats

Maldaner

Durgante

Murussi

et al. 1994

Integrative Physiological and Behavioral Science

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Chronic consumption of ethanol during pregnancy and lactation may lead to abnormalities in the fetus or infant. A group of female Wistar rats was submitted to ethanol treatment over a period of a month. A pair-fed control group received sucrose solution isocaloric to ethanol and the control group received water "ad libitum." Afterward, the females were mated with males over a period of 20 days. At birth, each litter was maximized to eight pups and the remaining ones were decapitated to remove the fetal blood and brains. No significant difference was observed in fetal body and brain weight at birth. During lactation the ethanol and pair-fed groups gained less weight than the control group. After weaning, their weight became similar. Fetal blood glucose levels were decreased in the ethanol-treated group. One hundred percent of the pair-fed and control females delivered live fetuses at term and all survived; only 40% of the females in the ethanol group delivered, and one pup did not survive. Chronic ethanol treatment pointed to a possible reduction in the fertility. It seems likely that the change in body weight of ethanol-fed dams was caused by undernutrition.

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Effects of Maternal Ethanol Consumption on the Offspring Sensory‐Motor Development, Ultrasonic Vocalization, Audiogenic Immobility Reaction and Brain Monoamine Synthesis

Cited by 21 publications

References 46 publications

Adolescent HIV-1 Transgenic Rats: Evidence for Dopaminergic Alterations in Behavior and Neurochemistry Revealed by Methamphetamine Challenge

Adolescent HIV-1 Transgenic Rats: Evidence for Dopaminergic Alterations in Behavior and Neurochemistry Revealed by Methamphetamine Challenge

Ethology and Neuropharmacology: Rodent Ultrasounds

Effects of chronic ethanol consumption on gestation and lactation in rats

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