Effects of maternal iron restriction in the rat on blood pressure, glucose tolerance, and serum lipids in the 3-month-old offspring

Lewis, Rohan M.; Petry, Clive J.; Ozanne, Susan E.; Hales, C. N.

doi:10.1053/meta.2001.22516

Cited by 111 publications

(113 citation statements)

References 27 publications

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“…Maternal iron restriction has been documented to cause increased systolic blood pressure and low birth weight, although no significant changes in glucose tolerance or insulin sensitivity were seen (27). In rodents maternal hypoxia has also been linked to Page 7 of 21 A c c e p t e d M a n u s c r i p t 7 low birth weight offspring and changes in cardiac gene expression (28).…”

Section: Evidence From Animal Modelsmentioning

confidence: 99%

Fetal programming of glucose–insulin metabolism

Jones

Ozanne

2009

Molecular and Cellular Endocrinology

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Epidemiological studies have shown a link between poor fetal growth and increased risk of developing type 2 diabetes. These observations are highly reproducible in many populations worldwide although the mechanisms behind them remain elusive.The 'Thrifty Phenotype Hypothesis' was proposed to explain the underlying causes of these relationships. Animal models of poor intrauterine nutrition have been utilised to help to define the causal factors and identify the molecular mechanisms. Programmed changes in beta cell function and insulin action have been a common feature of animal models of poor intrauterine nutrition. Fundamental underlying mechanisms are starting to emerge, including changes in the epigenotype and mitochondrial function.

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Section: Evidence From Animal Modelsmentioning

confidence: 99%

Fetal programming of glucose–insulin metabolism

Jones

Ozanne

2009

Molecular and Cellular Endocrinology

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“…Studies conducted in non-human primates improve our understanding of the mechanisms underlying human placental function. Diverse models of maternal nutrient restriction have been reported in a wide range of animals: protein restriction (33-60%) in rats, pigs [9], and rhesus monkeys [10]; micronutrient restriction in rats [11]; and global nutrient restriction (30-100%) in rats, sheep, and guinea pigs. Surprisingly, no data has been reported from non-human primates regarding effects of maternal nutrient restriction on placental IGF and systemic IGF changes.…”

Section: Introductionmentioning

confidence: 99%

The IGF Axis in Baboon Pregnancy: Placental and Systemic Responses to Feeding 70% Global Ad Libitum Diet

Li¹,

Levitz²,

Hubbard³

et al. 2007

Placenta

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Information on the influence of poor maternal nutrition on the regulation of responses to pregnancy, placental and fetal growth and development is critical to a better understanding of pregnancy physiology and pathophysiology. We determined normal changes and effects of controlled and monitored moderate nutrient restriction (NR) (global nutrient intake reduced to 70% of food consumed by mothers feeding ad libitum from 0.16 to 0.5 of gestation) in the baboon, on important hematological, biochemical, and hormonal indices of fetal growth and placental function. Serum IGF-I:IGFBP-3 ratio was lower in pregnant than control non-pregnant baboons feeding ad libitum. Serum concentrations of total and free IGF-I were decreased in NR mothers compared with controls (p < 0.05). The decrease in fetal IGF-I did not reach significance (p = 0.057). Serum IGF-I: IGFBP-3 ratio was decreased by NR in both mothers and fetuses. Maternal serum IGF-II was unchanged by NR. Placental IGF-I mRNA and protein abundance were similarly reduced whereas IGF-II mRNA increased in placental tissue of NR compared to control mothers. Systemic (maternal) and local (placental) IGFBP-1 and IGFBP-3 mRNA and protein abundance were unchanged by NR. Type 1 IGF receptor protein in the syncytiotrophoblast increased in NR. Type 2 IGF receptor protein was present in the stem villi core, and decreased after NR. We conclude that moderate NR in this important non-human primate model significantly disrupts the maternal and placental IGF-IGFBP axis and influences placental expression of this key system at the gene and protein level. Changes observed appear to be directed toward preserving placental growth.

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“…Vanadium shows insulin mimetic effects in vivo and in vitro when used in pharmacologic doses (17). Recently, dietary iron restriction in rat dams has been shown to increase hypertension and alter lipid metabolism in the offspring (18).…”

Section: Introductionmentioning

confidence: 99%

Does maternal dietary mineral restriction per se predispose the offspring to insulin resistance?

Lagishetty

Nemani

Krishna

et al. 2004

European Journal of Endocrinology

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Background: Maternal undernutrition is hypothesized to predispose the offspring to disease in adult life. The relevance of maternal macronutrient deficiency has been well studied but not that of micronutrients. Objective: To assess the effect of maternal dietary mineral restriction per se on oral glucose tolerance (OGT), insulin resistance (IR) and fat metabolism in offspring. Design: Female weanling Wistar/NIN rats received a control or a 50% mineral-restricted (MR) diet for 12 weeks, by which time MR rats had lower plasma Fe, Zn, Mg and Ca concentrations. Following mating with control males, a third of the MR dams were shifted to the control diet from parturition. Half of the pups born to the remaining MR dams were weaned onto the control diet while the other half continued on the MR diet. Results: Pregnant MR dams had a higher abortion rate, body weights of their pups at birth and weaning were lower and rehabilitation had no beneficial effect. No offspring had impaired OGT, and IR status was comparable among different groups on postnatal days 40, 70, 100 or 180. Compared with controls, total body electrical conductivity measurements indicated significantly higher body fat %, lower lean body mass and fat-free mass in MR offspring besides elevated plasma triacylglycerols. Mineral rehabilitation from parturition or weaning had little effect on these changes, which did not appear to be due to increased oxidative stress. Conclusions: Maternal MR per se resulted in an increase in body fat and in plasma triacylglycerol concentrations in the offspring. These changes had, however, no discernable effect on insulin sensitivity over the first 180 days of life.

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Effects of maternal iron restriction in the rat on blood pressure, glucose tolerance, and serum lipids in the 3-month-old offspring

Cited by 111 publications

References 27 publications

Fetal programming of glucose–insulin metabolism

Fetal programming of glucose–insulin metabolism

The IGF Axis in Baboon Pregnancy: Placental and Systemic Responses to Feeding 70% Global Ad Libitum Diet

Does maternal dietary mineral restriction per se predispose the offspring to insulin resistance?

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