Effects of maternal l-citrulline supplementation on renal function and blood pressure in offspring exposed to maternal caloric restriction: The impact of nitric oxide pathway

Tain, You‐Lin; Hsieh, Chih-Sung; Lin, I-Chun; Chen, Chih‐Cheng; Sheen, Jiunn‐Ming; Huang, Laura

doi:10.1016/j.niox.2010.03.005

Cited by 94 publications

(190 citation statements)

References 34 publications

Supporting

Mentioning

184

Contrasting

Order By: Relevance

“…9,10 We recently found that three-month-old offspring of dams exposed to 50% caloric restriction (CR) during late pregnancy and lactation had NO/ROS imbalance, increased ADMA, and increased BP. 11 We also found that treatment with the direct renin inhibitor, aliskiren, reduces ADMA and prevents the development of hypertension in young spontaneously hypertensive rats. 12 Thus, we intended to study whether aliskiren in early postnatal life reduces ADMA and prevents hypertension in offspring exposed to maternal CR.…”

Section: Introductionmentioning

confidence: 59%

“…Plasma levels of nitrite (NO 2 -) and NOx (NO 2 − + NO 3 − ) were measured by the Griess reaction as previously described. 11 Detection of l-arginine, ADMA, and symmetric dimethylarginine by high-performance liquid chromatography Plasma and tissue l-arginine, ADMA, and symmetric dimethylarginine (SDMA, an isomer of ADMA) levels were measured using high-performance liquid chromatography (HP series 1100, Agilent Technologies, Inc., Santa Clara, California, USA) using the o-phthalaldehyde and 3-mercaptopropionic acid derivatization reagent as described previously. 4 l-homoarginine (Fluka, Neu Ulm, Germany) was used as the internal standard.…”

Section: Animals and Pharmacological Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Aliskiren in early postnatal life prevents hypertension and reduces asymmetric dimethylarginine in offspring exposed to maternal caloric restriction

Hsu

Lee

Huang

et al. 2014

J Renin Angiotensin Aldosterone Syst

Self Cite

View full text Add to dashboard Cite

Introduction: Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is involved in hypertension. We tested whether aliskiren treatment in early postnatal life can reduce ADMA and regulate the reninangiotensin system to prevent hypertension in rat offspring exposed to maternal caloric restriction (CR). Materials and methods: Four groups of 12-week-old male offspring were sacrificed: control, CR, CR+aliskiren, and CR+losartan group. The CR group included offspring from 50% food-restricted maternal rats. The CR+aliskiren and CR+losartan groups were produced by treating CR offspring with oral aliskiren 10 mg/kg/day or losartan 20 mg/kg/day between 2-4 weeks of age, respectively. Results: Blood pressure increased in CR rats, which was prevented by aliskiren or losartan. CR increased plasma ADMA levels, which aliskiren prevented. Renal renin and prorenin receptor (PRR) expression increased in CR rats treated with aliskiren, whereas both were reduced by losartan. Both aliskiren and losartan decreased renal mRNA expression of angiotensinogen, angiotensin II type 2 receptor, and Mas in CR rats. However, aliskiren increased angiotensin II type 2 receptor and Mas protein levels in CR kidneys. Conclusions: Early aliskiren therapy prevents CR-induced hypertension via ADMA reduction, decreases angiotensinogen expression, and increases renal angiotensin II type 2 receptor and Mas protein.

show abstract

Section: Introductionmentioning

confidence: 59%

Section: Animals and Pharmacological Treatmentmentioning

confidence: 99%

Aliskiren in early postnatal life prevents hypertension and reduces asymmetric dimethylarginine in offspring exposed to maternal caloric restriction

Hsu

Lee

Huang

et al. 2014

J Renin Angiotensin Aldosterone Syst

Self Cite

View full text Add to dashboard Cite

show abstract

“…Plasma levels of nitrite (NO2 -) and NOx (NO2 -+NO3 -) were measured by the Griess reaction as previously described. 27 CIT, ARG, ADMA, and SDMA in plasma were measured using high-performance liquid chromatography (HP series 1100, Agilent Technologies) with the o-phthaldialdehyde 3-mercaptopropionic acid (OPA-3MPA) derivatization reagent as described previously. 12 The standards contained ARG, CIT, ADMA, and SDMA at 1-100 μmol/L, 1-100 μmol/L, 0.5-5 μmol/L, and 0.5-5 μmol/L, respectively.…”

Section: Biochemistry and High-performance Liquid Chromatographymentioning

confidence: 99%

High Citrulline-to-Arginine Ratio Associated With Blood Pressure Abnormalities in Children With Early Chronic Kidney Disease

Lin

Hsu

et al. 2013

Circ J

Self Cite

View full text Add to dashboard Cite

Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp itric oxide (NO), a potent vasodilator, regulates systemic blood pressure (BP) and local blood flow. A deficiency of NO can lead to vasoconstriction and cause diseases including hypertension and chronic kidney disease (CKD). 1-3 Reduced l-arginine (ARG) bioavailability and increased asymmetric dimethylarginine (ADMA) both contribute to NO deficiency. 3 ARG is a substrate for the synthesis of NO and this constitutes the rationale for manipulating ARG metabolism as a therapeutic approach for kidney disease and hypertension. 4 Because ARG is involved in multiple metabolic pathways, 5 there are discrepant findings in the literature according to the plasma level of ARG in patients with CKD and hypertension. 6-8 ARG can be metabolized by arginase to generate ornithine, which can be further converted to l-citrulline (CIT). In contrast, the body can use CIT to make ARG via the argininosuccinate (AS) pathway involving AS synthetase and lyase. 9 In human and experimental CKD, renal CIT uptake is diminished, the amount of CIT converted to ARG in the kidney is reduced, and plasma CIT levels and turnover are elevated. 6-8,10,11 We and others demonstrated that reduced renal ARG availability precedes hypertension in the young spontaneously hypertensive rat (SHR). 12, 13 We also found that restoration of renal ARG availability is associated with lowering BP in young SHR. 12 Renal ARG level, however, is not correlated with the levels of ARG and dimethylarginine in the plasma. 14 These findings suggest that decreased renal ARG level could develop in early CKD causing BP abnormalities, which might be predicted by plasma CIT level and CIT-to-ARG ratio.ADMA can compete with ARG for NO synthase (NOS) to generate NO and CIT. 15,16 Therefore, the ARG-to-ADMA ratio is considered to represent NO bioavailability. 17 ADMA is mainly metabolized by dimethylarginine dimethylaminohydrolase (DDAH) in the kidney. Unlike ADMA, another structural Background: Nitric oxide (NO) is involved in hypertension and chronic kidney disease (CKD). NO synthase can metabolize l-arginine (ARG) to generate NO and l-citrulline (CIT). Two methylated ARG derivatives, asymmetric and symmetric dimethylarginine, are also involved in NO deficiency. Thus it was hypothesized that their combined ratios relate to blood pressure (BP) abnormalities in children with early CKD.

show abstract

“…We recently observed that renal programming and hypertension developed in the adult male offspring of mother rats exposed to caloric restriction [6,7], diabetes [8], dexamethasone treatment [9,10] and high-fructose (HF) diet [11]. A number of mechanisms, including glucocorticoid effects, oxidative stress, epigenetic regulation, alterations of renin-angiotensin system (RAS), impaired tubular sodium handling and reduction in nephron numbers, have been put forward to interpret renal programming [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Maternal fructose-intake-induced renal programming in adult male offspring

Tain

Lee

et al. 2015

The Journal of Nutritional Biochemistry

Self Cite

View full text Add to dashboard Cite

Effects of maternal l-citrulline supplementation on renal function and blood pressure in offspring exposed to maternal caloric restriction: The impact of nitric oxide pathway

Cited by 94 publications

References 34 publications

Aliskiren in early postnatal life prevents hypertension and reduces asymmetric dimethylarginine in offspring exposed to maternal caloric restriction

Aliskiren in early postnatal life prevents hypertension and reduces asymmetric dimethylarginine in offspring exposed to maternal caloric restriction

High Citrulline-to-Arginine Ratio Associated With Blood Pressure Abnormalities in Children With Early Chronic Kidney Disease

Maternal fructose-intake-induced renal programming in adult male offspring

Contact Info

Product

Resources

About