Effects of Maternal Multimicronutrient Supplementation on the Mental Development of Infants in Rural Western China: Follow-up Evaluation of a Double-Blind, Randomized, Controlled Trial

Li, Qiang; Yan, Hong; Zeng, Lingxia; Cheng, Yue; Liang, Weifeng; Dang, Shaonong; Wang, Quanli; Tsuji, Ichiro

doi:10.1542/peds.2008-3007

Cited by 99 publications

(109 citation statements)

References 21 publications

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“…There were no differences between children at 3 and 6 months, but at 12 months, children of mothers who had received MMNs had a higher mental development index score by 1.22 (compared with IFA) and 1.00 (compared with folic acid alone) ( p = 0.02). There were no effects on motor development [25] .…”

Section: Biological Effects Child Engagement Cognition Nutritionmentioning

confidence: 81%

Iron and Cognitive Development: What Is the Evidence?

2017

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The theoretical irreversible damage that iron deficiency and iron deficiency anemia can exert on child development makes a compelling argument for action to alleviate the burden. However, a critical analysis of evidence from iron interventions in early life is necessary to determine whether and how iron interventions improve cognitive outcomes. Key iron interventions used in clinical and public health practice include oral iron supplementation and, in young children, iron-containing multiple micronutrient powders. This article examines the evidence to answer 4 main questions. (1) Does antenatal iron supplementation influence long-term child cognitive development? (2) Does oral iron supplementation in preschool children improve short-term cognitive development? (3) Does oral iron supplementation in older children improve cognitive development? And (4), can provision of iron harm cognitive development? Early trials indicated benefit from parenteral iron in young children regardless of anemia status. There also appears to be evidence for benefit using oral iron treatment on cognitive performance in anemic primary school children. However, antenatal and early childhood oral iron intervention studies show inconsistent effects on early and long-term childhood cognitive outcomes. These data suggest either that (a) effects from oral iron on cognitive development in young children are small or nonexistent or that (b) heterogeneity between trials and the low quality of many studies make assessment of effect difficult. Importantly, few large, placebo-controlled trials in under-2-year-old children in low-income settings assessing effects of iron interventions on cognition have been performed; high-quality, placebo-controlled, adequately powered trials of universal iron interventions on cognitive performance in young children are urgently needed to justify policies of universal iron intervention in this group.

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Section: Biological Effects Child Engagement Cognition Nutritionmentioning

confidence: 81%

Iron and Cognitive Development: What Is the Evidence?

2017

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“…This review found some evidence that multivitamin and mineral supplementation might positively influence certain aspects of brain development in children (Leung et al, 2011). The review included six trials on multiple-micronutrient supplementations conducted in Peru, rural Taiwan, Tanzania (on HIV infected mothers), and in rural China, Indonesia and Bangladesh, where mothers were poorly nourished (Joos et al, 1983;Schmidt et al, 2004;McGrath et al, 2006;Tofail et al, 2008;Li et al, 2009;Caulfield et al, 2010). A very recent randomized controlled trial in Indonesia found that multiple micronutrient supplementation in undernourished pregnant mothers resulted in improved motor development, visual attention and spatial ability in pre-schoolers (Prado et al, 2012).…”

Section: Multivitamin and Mineral Supplementationmentioning

confidence: 99%

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

Nyaradi¹,

Li²,

Hickling³

et al. 2015

Prenatal and Childhood Nutrition

129

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This review examines the current evidence for a possible connection between nutritional intake (including micronutrients and whole diet) and neurocognitive development in childhood. Earlier studies which have investigated the association between nutrition and cognitive development have focused on individual micronutrients, including omega-3 fatty acids, vitamin B12, folic acid, choline, iron, iodine, and zinc, and single aspects of diet. The research evidence from observational studies suggests that micronutrients may play an important role in the cognitive development of children. However, the results of intervention trials utilizing single micronutrients are inconclusive. More generally, there is evidence that malnutrition can impair cognitive development, whilst breastfeeding appears to be beneficial for cognition. Eating breakfast is also beneficial for cognition. In contrast, there is currently inconclusive evidence regarding the association between obesity and cognition. Since individuals consume combinations of foods, more recently researchers have become interested in the cognitive impact of diet as a composite measure. Only a few studies to date have investigated the associations between dietary patterns and cognitive development. In future research, more well designed intervention trials are needed, with special consideration given to the interactive effects of nutrients.

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“…We expect this to change. For example, Li et al (2009) analyze the effects of a double blind RCT that provided multi-micronutrient supplementation to several thousand pregnant women in rural China on measures of offspring mental and psychomotor development at up to age 1. Similarly, Vaidya et al (2008) implemented an RCT in Nepal to identify the effects of iron or folic acid supplementation during the prenatal period on various measures of childhood size, illness and blood pressure.…”

Section: Random Assignmentmentioning

confidence: 99%

Fetal Origins and Parental Responses

2013

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How do parental investments respond to health endowments at birth? Recent studies have combined insights from an earlier theoretical literature on household resource allocation with improved identification strategies to capture causal effects of early life health shocks. We describe empirical challenges in identifying behavioral responses and how recent studies have sought to address these. We then discuss the emerging literature on "dynamic complementarities" in parental investments arising from the staged, developmental nature of capability production and how capabilities may have multiple dimensions. The bulk of the empirical evidence to date suggests that parental investments reinforce initial endowment differences.3

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Effects of Maternal Multimicronutrient Supplementation on the Mental Development of Infants in Rural Western China: Follow-up Evaluation of a Double-Blind, Randomized, Controlled Trial

Abstract: Compared with iron and folic acid supplementation, the administration of multimicronutrients to pregnant women improved the mental development of their children at 1 year of age.

Cited by 99 publications

References 21 publications

Iron and Cognitive Development: What Is the Evidence?

Iron and Cognitive Development: What Is the Evidence?

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

Fetal Origins and Parental Responses

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