Effects of maternal obesity on maternal and fetal plasma concentrations of adiponectin and expression of adiponectin and its receptor genes in cotyledonary and adipose tissues at mid- and late-gestation in sheep

Fensterseifer, S.R.; Austin, Kathy J.; Ford, Stephen P.; Alexander, Brenda M.

doi:10.1016/j.anireprosci.2018.08.033

Cited by 11 publications

(8 citation statements)

References 51 publications

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“…Fensterseifer et al reported in a sheep model that maternal obesity resulted in changes in adiponectin expression in fetal adipose tissue as well as adipogenic and circulating concentrations of total adiponectin. Although adiposity in pregnant ewes did not alter maternal adiponectin, it may have influenced fetal adipogenesis via alterations in the expression of adiponectin, PPAR-γ and sterol regulatory element-binding factor (SREBF)1 in fetal adipose tissue (Fensterseifer et al 2018). Earlier work in the sheep had also reported that increased maternal nutrition (55% above maintenance) led to stimulation of leptin and adiponectin mRNA expression in fetal perirenal adipose depots (Muhlhausler et al 2007b).…”

Section: Leptinmentioning

confidence: 93%

The role of adipokines in developmental programming: evidence from animal models

Reynolds

Vickers

2019

Journal of Endocrinology

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Alterations in the environment during critical periods of development, including altered maternal nutrition, can increase the risk for the development of a range of metabolic, cardiovascular and reproductive disorders in offspring in adult life. Following the original epidemiological observations of David Barker that linked perturbed fetal growth to adult disease, a wide range of experimental animal models have provided empirical support for the developmental programming hypothesis. Although the mechanisms remain poorly defined, adipose tissue has been highlighted as playing a key role in the development of many disorders that manifest in later life. In particular, adipokines, including leptin and adiponectin, primarily secreted by adipose tissue, have now been shown to be important mediators of processes underpinning several phenotypic features associated with developmental programming including obesity, insulin sensitivity and reproductive disorders. Moreover, manipulation of adipokines in early life has provided for potential strategies to ameliorate or reverse the adverse sequalae that are associated with aberrant programming and provided insight into some of the mechanisms involved in the development of chronic disease across the lifecourse.

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Section: Leptinmentioning

confidence: 93%

The role of adipokines in developmental programming: evidence from animal models

Reynolds

Vickers

2019

Journal of Endocrinology

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“…Similarly, as milk-producing ruminants, goats and sheep are also regulated by PPARγ. Many studies indicate that PPARγ is involved in adipocyte differentiation and adipogenesis in sheep/goats [59][60][61][62][63], though, in addition to fat regulation, PPARγ was previously thought to be involved in the regulation of hormones in goats and sheep [64,65]. However, there has been some relevant research in recent years.…”

Section: Pparγmentioning

confidence: 99%

The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation

Zong

Zhang

et al. 2022

Agriculture

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Beta-oxidation(β-oxidation) is an important metabolic process involving multiple steps by which fatty acid molecules are broken down to produce energy. The very long-chain fatty acids (VLCFAs), a type of fatty acid (FA), are usually highly toxic when free in vivo, and their oxidative metabolism depends on the peroxisomal β-oxidation. For a long time, although β-oxidation takes place in both mitochondria and peroxisomes, most studies have been keen to explore the mechanism of β-oxidation in mitochondria while ignoring the importance of peroxisomal β-oxidation. However, current studies indicate that it is hard to provide effective treatment for diseases caused by the disorder of peroxisomal β-oxidation, such as X-ALD, SCOX deficiency, and D-BP deficiency; thus, actions should be taken to solve this problem. Based on existing research results, this review will summarize the importance of peroxisomal β-oxidation and help further learning.

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“…The preceding studies on mRNA levels used to determine the expression of AdipoR1 and AdipoR2 in various tissues 18 . However, adiponectin receptor protein synthesis and release rely not only on mRNA but also other factors involved in translation 19 , making these levels of adiponectin receptor protein determination essentially important in serum of individuals. The adiponectin levels have been well defined in obese people but to study the instigating role of receptors and their concentration in serum we conducted this study.…”

Section: Discussionmentioning

confidence: 99%

Determining the Receptor Proteins AdipoR1, Leptin and Lipid Status in Serum; Mitigating its impact on Obese and Healthy Individuals

Talat¹,

Liaqat²,

Usman³

et al. 2021

PJMHS

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Aim: To investigate role of AdipoR1 concentrations and leptin levels in obese and healthy subjects along with their lipid status Methods: This cross sectional study was conducted in residents of Sialkot city and included 132 subjects. Each group had 66 participants. Mean age was 39.6±0.97 years. Mean BMI for obese subjects was 31.55±0.6 while healthy group BMI was 20.5±0.2. Individuals with known history of diabetes, hypertension, chronic kidney disease, any malignancy and history of lipid lowering, antihypertensive, antipsychotics and antiepileptic were excluded. Fasting blood samples were taken after informed and written consent. Samples were centrifuged to extract serum and stored for analysis by ELISA method for AdiopR1 and leptin while lipid profile was determined by kits by Randox Diagnostics using micro lab. Data was analyzed by SPSS v. 26. Comparison between groups was carried out by Mann-Whitney U test. Results: Our study revealed higher levels of serum AdipoR1 (28.9±22.86 ng/mL), leptin (320.7±59.38 pg/mL), cholesterol (216±5.31 mg/dl), triglyceride (177.8±4.93 mg/dl) and LDL (139.3±4.56 mg/dl) in obese when compared with healthy individuals, AdiopoR1 (17.8±1.96ng/mL), leptin (219±20.76 pg/mL), cholesterol (179.8±3.25 mg/dl), triglyceride (149.8±3.17mg/dl), LDL (108.5±25.7 mg/dl) respectively. No statistical difference was found for HDL between groups. Conclusion: Our Study concludes that rising levels of AdipoR1 and leptin in addition to lipid profile are associated with obesity. Keywords: Obesity, Receptor Proteins AdipoR1, Leptin, lipid status, adipose tissue

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Effects of maternal obesity on maternal and fetal plasma concentrations of adiponectin and expression of adiponectin and its receptor genes in cotyledonary and adipose tissues at mid- and late-gestation in sheep

Cited by 11 publications

References 51 publications

The role of adipokines in developmental programming: evidence from animal models

The role of adipokines in developmental programming: evidence from animal models

The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation

Determining the Receptor Proteins AdipoR1, Leptin and Lipid Status in Serum; Mitigating its impact on Obese and Healthy Individuals

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