Effects of maternal protein restriction on central and peripheral renin-angiotensin systems in male rat offspring

Barros, Monique Assis de Vasconcelos; Alves, José Luiz de Brito; Barros, Rayssa Gabriella Nery; Silva, Manuel Santana e; Nasser, Souad; Tourneur, Yves; Leandro, Carol V. G.; Vidal, Hubert; Pirola, Luciano; Costa‐Silva, João Henrique

doi:10.1016/j.lfs.2020.118574

Cited by 7 publications

(2 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Protein restriction in early life impairs lipid and glucose metabolism, increasing the predisposition to obesity and cardio-metabolic diseases throughout life [ 47 , 48 , 49 , 50 ]. In addition, perinatal protein restriction leads to decreased insulin and leptin sensitivity, increased body adiposity, decreased satiety, and reduced basal energy expenditure [ 51 ].…”

Section: Quercetin Intervention In Gestational Undernutritionmentioning

confidence: 99%

Evidence for Quercetin as a Dietary Supplement for the Treatment of Cardio-Metabolic Diseases in Pregnancy: A Review in Rodent Models

Costa

Souza

Lacerda

et al. 2022

Foods

Self Cite

View full text Add to dashboard Cite

Quercetin supplementation during pregnancy and lactation has been linked to a lower risk of maternal cardio-metabolic disorders such as gestational diabetes mellitus (GDM), dyslipidemia, preeclampsia, attenuation of malnutrition-related conditions, and gestational obesity in animal studies. Pre-clinical studies have shown that maternal supplementation with quercetin reduces cardio-metabolic diseases in dams and rodents’ offspring, emphasizing its role in modifying phenotypic plasticity. In this sense, it could be inferred that quercetin administration during pregnancy and lactation is a viable strategy for changing cardio-metabolic parameters throughout life. Epigenetic mechanisms affecting the AMP-activated protein kinase (AMPK), nuclear factor-kappa B (NF-κB), and phosphoinositide 3-kinase (PI3 K) pathways could be associated with these changes. To highlight these discoveries, this review outlines the understanding from animal studies investigations about quercetin supplementation and its capacity to prevent or decrease maternal and offspring cardio-metabolic illnesses and associated comorbidities.

show abstract

Section: Quercetin Intervention In Gestational Undernutritionmentioning

confidence: 99%

Evidence for Quercetin as a Dietary Supplement for the Treatment of Cardio-Metabolic Diseases in Pregnancy: A Review in Rodent Models

Costa

Souza

Lacerda

et al. 2022

Foods

Self Cite

View full text Add to dashboard Cite

show abstract

“…Studies in rodents have consistently reported that 6-9% protein restriction in pregnant mothers resulted in hypertension in adult offspring (14)(15)(16)(17). Previous studies led to several hypotheses about the underlying mechanisms, involving the suppression of the newborn renin-angiotensin system (18), impairment to nephrogenesis (19), triggering oxidative disruption in the medulla oblongata (20), or hindering the hypothalamic-pituitary-adrenal axis (21). However, there have been sparse reports on uncovering the role of epigenetic regulation in the pathology of hypertension.…”

Section: Introductionmentioning

confidence: 99%

Postnatal nutrition environment reprograms renal DNA methylation patterns in offspring of maternal protein-restricted stroke-prone spontaneously hypertensive rats

Ando

Miyoshi

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

Maternal malnutrition hampers the offspring health by manipulating the epigenome. Recent studies indicate that the changes in DNA methylation could be reversed by afterbirth nutrition supplementation. In this study, we used DNA methylation arrays to comprehensively investigate the DNA methylation status of the renal promoter regions and the effects of postnatal protein intake on DNA methylation. We fed stroke-prone spontaneously hypertensive (SHRSP) rat dams a normal diet or a low-protein diet during pregnancy, and their 4-week-old male offspring were fed a normal diet or a high−/low-protein diet for 2 weeks. We found that the methylation status of 2,395 differentially methylated DNA regions was reprogrammed, and 34 genes were reset by different levels of postnatal protein intake in the offspring. Among these genes, Adora2b, Trpc5, Ar, Xrcc2, and Atp1b1 are involved in renal disease and blood pressure regulation. Our findings indicate that postnatal nutritional interventions can potentially reprogram epigenetic changes, providing novel therapeutic and preventive epigenetic targets for salt-sensitive hypertension.

show abstract

Neuroendocrine Programming Mechanism of Fetal-Originated Disease

Kou,

Liu

2024

Fetal Origin of Diseases

View full text Add to dashboard Cite

Effects of maternal protein restriction on central and peripheral renin-angiotensin systems in male rat offspring

Cited by 7 publications

References 46 publications

Evidence for Quercetin as a Dietary Supplement for the Treatment of Cardio-Metabolic Diseases in Pregnancy: A Review in Rodent Models

Evidence for Quercetin as a Dietary Supplement for the Treatment of Cardio-Metabolic Diseases in Pregnancy: A Review in Rodent Models

Postnatal nutrition environment reprograms renal DNA methylation patterns in offspring of maternal protein-restricted stroke-prone spontaneously hypertensive rats

Neuroendocrine Programming Mechanism of Fetal-Originated Disease

Contact Info

Product

Resources

About