Effects of Maternal Supplementation With Omega-3 Precursors on Human Milk Composition

Mazurier, E.; Rigourd, Virginie; Perez, Paul; Buffin, Rachel; Couëdelo, Leslie; Vaysse, Carole; Belcadi, Wafae; Sitta, Rémi; Nacka, Fabienne; Lamireau, Delphine; Cambonie, Gilles; Picaud, Jean-Charles; Billeaud, Claude

doi:10.1177/0890334417691946

Cited by 38 publications

(35 citation statements)

References 60 publications

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“…There is great interest in identifying modifiable factors influencing the milk microbiota, with studies to date reporting inconsistent associations for mode of delivery, maternal diet, and maternal BMI (Cabrera-Rubio et al, 2012;Li et al, 2017;McGuire and McGuire, 2017;Sakwinska et al, 2016;Urbaniak et al, 2016). Maternal diet and BMI are interrelated, and both can modify gut microbiota composition (Collado et al, 2008;Wu et al, 2011) as well as the macro-and micro-nutrient profile of human milk (Mazurier et al, 2017;McGuire et al, 2017), altering the niche for milk microbiota. Maternal BMI is also positively associated with Caesarean section delivery (Pettersen-Dahl et al, 2018).…”

Section: Modifiable Maternal Factors and Milk Microbiotamentioning

confidence: 99%

Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors

Moossavi

Sepehri

Robertson

et al. 2019

Cell Host & Microbe

392

422

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Section: Modifiable Maternal Factors and Milk Microbiotamentioning

confidence: 99%

Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors

Moossavi

Sepehri

Robertson

et al. 2019

Cell Host & Microbe

392

422

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“…We have followed the evolution of fatty acids of maternal milks in France [8] over the past 17 years and noticed through this study the doubling of -linolenic acid from 0.5% of total fatty acids to about 1%. But only by bringing a supplement to the nursing mother of 25 g/d of rapeseed oil +25 g of margarine omega3 St Hubert that we reach (see curves) 2.15% -linolenic acid which is in the recommended need between 1.7% and 4% of the total fatty acids and has reached the ratio LA/ALA = 5.5 in breast milk, on the other hand it is only the consumption of mackerel 2 times 170 g/week (approximately 350 mg/day of DHA) which increased the DHA level to 0.5% [9].…”

Section: Evolution Of Ideas On Lipidsmentioning

confidence: 68%

Breast Milk Substitutes: Changing Ideas

Billeaud¹

2018

JFSE

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Breast milk is the model for infant feeding. In the absence of breast milk, substitutes have been created whose composition attempts to copy that of breast milk. However, it is impossible to make from cow's milk the copy of human milk given that it is composed of a thousand substances which have for some the function of nutrients and for others (the most numerous) properties bioactive. In addition, there is no fixed milk for the same mother but mothers whose composition varies over time: colostrum (first 5 days, transition milk (5 to 30 days), mature milk after one month, but also during the day: milk is not the same in the morning, at noon and in the evening, and even worse: at the beginning and at the end of the summer. The mother's diet: although milk proteins and carbohydrates are only slightly influenced, there is a strong correlation between dietary lipids and breast milk, as well as minerals, vitamins and trace elements. On the other hand, the composition of breast milk that gave birth to a premature child is higher in protein than that of the milk of a mother of a newborn baby. Despite all these constraints, doctors and industrialists of the agro-alimentary do not cease to make progress to create formulas of milk more and more close to the nutritive values of the human milk.... But it is an endless challenge; In fact when a complex protein or oligosaccharides and polyunsaturated fatty acids are discovered in the mother's milk, it is necessary to evaluate by means of studies that are often long to discover their exact role and to demonstrate the correct dosage to be added in the formulas.

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“…Besides, variability in HM composition at different postnatal periods may require the application of specific strategies to optimize the nutrient supply to NB, particularly preterm infants [12]. Maternal supplementation studies have been conducted to improve HM energy intake and lipid profile [13][14][15][16]. Studies conducted in countries in Europe, the United States, and Brazil have supplemented nursing mothers with docosahexaenoic AG (DHA) capsules [13,15,17], eicosapentaenoic AG (EPA) capsules in addition to DHA [16,18], rapeseed oil, and omega 3 enriched margarine [14], sardine consumption [19], and diets with different levels of arachidonic acid [18].…”

Section: Introduction / Backgroundmentioning

confidence: 99%

Effect of maternal dietary supplementation with Brazil nut (Bertholletia excelsa) on the nutritional profile of human milk: randomized controlled trial - rationale, design, and methods

Rodrigues¹,

Reis²,

Correa³

et al. 2020

Preprint

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Background The human milk (HM) composition reflects the nutritional status and dietary intake of the nursing mother, especially regarding the fatty acids (FA) intakes. Evidence has shown that Brazil nut is a good source of FA (mono and polyunsaturated) and selenium. Thus, this study tests the hypothesis that the consumption of this nut during lactation can modify the nutritional profile of HM, increase its energy density and selenium content, and improve the lipid profile. Therefore, this study aimed to describe the design and methods of the Randomized Clinical Trial (RCT): Effect of maternal dietary supplementation with Brazil nut (Bertholletia excelsa) on the nutritional profile of HM. Method/Design It is a crossover study, conducted with mother-infant dyads (with infants born at full-term) recruited from a maternity hospital and followed up to the third month postpartum in a pediatric office. Sociodemographic, lifestyle, obstetric, and birth data were collected at 7 days postpartum. Maternal nutrition assessment data (anthropometry, body composition, food intake, biochemical tests), HM samples, and infant anthropometric and health assessment data were collected on average at 37, 52, 75, and 90 days postpartum. The nursing mothers were randomly allocated into two groups: group (1) started with supplementation of 1.5 g/day Brazil nut (case) for 15 days, followed by 15-day washout period; after the washout, the group was then considered as control and received follow-up monitoring for another 15 days; group (2) started as control for 15 days, which was followed by a washout period of 15 days, then they initiated supplementation with Brazil nut for 15 days (case).Discussion To the best of our knowledge, this is the first RCT to evaluate the effect of maternal Brazil nut supplementation on HM nutritional profile. This is a promising research area that can provide findings which will contribute to improving health and nutrition of infants, especially premature infants, admitted to Neonatal Intensive Care Units.

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Effects of Maternal Supplementation With Omega-3 Precursors on Human Milk Composition

Abstract: In lactating women, omega-3 supplementation via the combination of enriched margarine and rapeseed oil increased the ALA content of human milk and generated the most favorable LA-ALA ratio for LC-PUFA synthesis.

Cited by 38 publications

References 60 publications

Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors

Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors

Breast Milk Substitutes: Changing Ideas

Effect of maternal dietary supplementation with Brazil nut (Bertholletia excelsa) on the nutritional profile of human milk: randomized controlled trial - rationale, design, and methods

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