The effects of different replacement levels of micro-silica (MS), colloidal nano-silica (CS) and also the combined addition of MS and CS on the behavior of self-compacting lightweight concrete (SCLC) were studied using the general full factorial design method. Three factors, including water to binder ratio (w/b) with two levels of 0.35 and 0.45, CS with four replacement levels of 0, 1, 3 and 5%, and MS with two replacement levels of 0% and 10% were chosen and three tests were conducted for each response. The modulus of elasticity, compressive strength and water absorption were selected as the responses at the age of 28 days. Also, using multiple regression analysis, acceptable prediction regression models were derived. The analysis of variance (ANOVA) showed that the effects of all three factors on fresh and hardened properties of SCLCs were significant. The results displayed that the mentioned properties for the SCLC specimens containing MS or CS improved, but the best performance was obtained in ternary mixes which were created by adding both MS and CS simultaneously. The optimal condition for having the best result of SCLC was obtained when the amounts of MS and CS were 10% and 3%, respectively.