Effects of Measurement Center Shift on Ganglion Cell–inner Plexiform Layer Thickness Measurements

Kim, Kyoung-Nam; Shin, Il-Hwan; Kwak, Baek-Soo; Sung, Jae-Yun; Lim, Hyung Bin; Jo, Young–Joon; Kim, Jung‐Yeul

doi:10.1097/opx.0000000000001251

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…This is equivalent to a variation of 215µm and 175µm, respectively. This order of variation would result in signi cant measurement errors in OCT. 14,15 Signal strength was found better in low myopes (Table 2). Previous studies have demonstrated impact of low signal strength on OCTA measurements.…”

Section: Discussionmentioning

confidence: 92%

“…Pak et al 14 reported that a decentration greater than 200µm from the fovea could lead to OCT foveal thickness at the central 1-mm zone being reduces by 9µm. Kim et al 15 moved the measurement location arti cially to simulate gaze instability. A horizontal shift greater than 59µm or a vertical shift greater than 47µm could reduce the ganglion cell-inner plexiform layer thickness signi cantly.…”

Section: Introductionmentioning

confidence: 99%

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Fixation Stability and Deviation in Optical Coherence Tomography Angiography Using Soft Contact Lens Correction in Myopes

Lam

Lau

Wong

et al. 2021

Preprint

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ObjectiveTo compare fixation deviation and stability with soft contact lens correction and device built-in auto-focus system during optical coherence tomography angiography (OCTA).MethodsThis observational study measured OCTA metrics first with contact lens correction, followed by removal of contact lenses, using the device auto-focus system at a University Optometry Clinic, Hong Kong. All participants were habitual soft contact lens wearers with either low or high myopia. OCTA measurements were obtained using a spectral domain OCTA. Fixation deviation was distance (in pixels) of the fovea to the center of the OCTA measurement grid. Fixation stability was test-retest repeatability (TRR) and coefficient of variation (CV) of fixation deviation from three consecutive OCTA measurements. OCTA metrics included vessel length density (VD), perfusion density (PD), and foveal avascular zone (FAZ) area. Averaged OCTA metrics were calculated from three measurements and compared between the two correction methods.ResultsThe mean ± SD spherical equivalent of 74 eyes from 74 myopes measured was -1.94D ± 0.75D in low myopes (n=37) and -7.97D ± 1.31D in high myopes (n=37). When corrected with contact lenses, visual acuities of high myopes (median [IQR], -0.06 [0.08] logMAR) and low myopes (0.02 ± 0.08 logMAR) were similar (P = 0.060), and with similar fixation deviation (5.0 ± 2.2 pixels vs 5.3 [3.6] pixels; P = 0.689). High myopes had poorer fixation stability than low myopes (TRR: 10.2 pixels vs 7.5 pixels; CV: 65% vs 54%, respectively). The worst fixation stability occurred when high myopes were corrected using the auto-focus system (TRR: 12.5 pixels, CV: 72%). The difference in VD and PD was within 1mm-1 and 1%, respectively. The FAZ area was similar.Conclusions High myopes had more stable fixation when corrected when wearing contact lenses. Subjects with good contact lens corrected visual acuity should wear their contact lenses during OCTA measurements.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Fixation Stability and Deviation in Optical Coherence Tomography Angiography Using Soft Contact Lens Correction in Myopes

Lam

Lau

Wong

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…This is equivalent to a variation of 215 μm and 175 μm, respectively. This order of variation would result in significant measurement errors in OCT 14 , 15 .…”

Section: Discussionmentioning

confidence: 99%

“…Pak et al 14 reported that a decentration greater than 200 μm from the fovea could lead to OCT foveal thickness at the central 1-mm zone being reduces by 9 μm. Kim et al 15 moved the measurement location artificially to simulate gaze instability. A horizontal shift greater than 59 μm or a vertical shift greater than 47 μm could reduce the ganglion cell-inner plexiform layer thickness significantly.…”

Section: Introductionmentioning

confidence: 99%

Fixation stability and deviation in optical coherence tomography angiography using soft contact lens correction in myopes

Lam

Lau

Wong

et al. 2021

Sci Rep

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To compare fixation deviation and stability with soft contact lens correction and device built-in auto-focus system during optical coherence tomography angiography (OCTA). This observational study measured OCTA metrics first with contact lens correction, followed by removal of contact lenses, using the device auto-focus system at a University Optometry Clinic, Hong Kong. All participants were habitual soft contact lens wearers with either low or high myopia. OCTA measurements were obtained using a spectral domain OCTA. Fixation deviation was distance (in pixels) of the fovea to the center of the OCTA measurement grid. Fixation stability was test–retest repeatability (TRR) and coefficient of variation (CV) of fixation deviation from three consecutive OCTA measurements. OCTA metrics included vessel length density (VD), perfusion density (PD), and foveal avascular zone (FAZ) area. Averaged OCTA metrics were calculated from three measurements and compared between the two correction methods. The mean ± SD spherical equivalent of 74 eyes from 74 myopes measured was − 1.94D ± 0.75D in low myopes (n = 37) and − 7.97D ± 1.31D in high myopes (n = 37). When corrected with contact lenses, visual acuities of high myopes (median [IQR], − 0.06 [0.08] logMAR) and low myopes (− 0.02 ± 0.08 logMAR) were similar (P = 0.060), and with similar fixation deviation (5.0 ± 2.2 pixels vs 5.3 [3.6] pixels; P = 0.689). High myopes had poorer fixation stability than low myopes (TRR: 10.2 pixels vs 7.5 pixels; CV: 65% vs 54%, respectively). The worst fixation stability occurred when high myopes were corrected using the auto-focus system (TRR: 12.5 pixels, CV: 72%). The difference in VD and PD was within 1 mm−1 and 1%, respectively. The FAZ area was similar. Difference in OCTA metrics was small in each refractive group (< 1 mm−1 in VD, and < 2% in PD). High myopes had more stable fixation when corrected when wearing contact lenses. Subjects with good contact lens corrected visual acuity should wear their contact lenses during OCTA measurements.

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Comparison of macular thickness in diabetic patients acquired from optical coherence tomography mode and optical coherence tomography angiography mode in Cirrus HD-OCT 5000

Wong,

Ahmat,

Zee

et al. 2024

Journal of Optometry

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Effects of Measurement Center Shift on Ganglion Cell–inner Plexiform Layer Thickness Measurements

Abstract: The impact of changes associated with shifting of the measurement center should be taken into consideration when measuring GCIPL thickness in patients with retinal diseases, glaucoma, or neuro-ophthalmological conditions.

Cited by 3 publications

References 25 publications

Fixation Stability and Deviation in Optical Coherence Tomography Angiography Using Soft Contact Lens Correction in Myopes

Fixation Stability and Deviation in Optical Coherence Tomography Angiography Using Soft Contact Lens Correction in Myopes

Fixation stability and deviation in optical coherence tomography angiography using soft contact lens correction in myopes

Comparison of macular thickness in diabetic patients acquired from optical coherence tomography mode and optical coherence tomography angiography mode in Cirrus HD-OCT 5000

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