Effects of medial prefrontal transcranial alternating current stimulation on neural activity and connectivity in people with Huntington’s disease and neurotypical controls

Davis, Marie-Claire; Fitzgerald, Paul B.; Bailey, Neil W.; Sullivan, Caley; Stout, Julie C.; Hill, Aron T.; Hoy, Kate E.

doi:10.1016/j.brainres.2023.148379

Cited by 5 publications

(1 citation statement)

References 105 publications

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“…Regarding cognitive rehabilitation, it has emerged that VR-and PC-based methods as well as NIBS techniques are feasible and may have a promising effect in individuals with HD. This is in line with previous studies that highlighted the beneficial role in cognitive training of healthy elderly individuals, patients with mild cognitive impairment, and various neurological and dementia-related conditions [60][61][62][63], including Parkinson's disease [64] and multiple sclerosis [65,66]. Indeed, cognitive training has been shown to improve cognitive function by promoting neuroplasticity through structural and functional changes in the brain [67].…”

Section: Discussionsupporting

confidence: 91%

The Role of Innovation Technology in the Rehabilitation of Patients Affected by Huntington’s Disease: A Scoping Review

Maggio,

Billeri,

Cardile

et al. 2023

Biomedicines

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Huntington’s disease is an autosomal dominant neurodegenerative disease caused by the repetition of cytosine, adenine, and guanine trinucleotides on the short arm of chromosome 4p16.3 within the Huntingtin gene. In this study, we aim to examine and map the existing evidence on the use of innovations in the rehabilitation of Huntington’s disease. A scoping review was conducted on innovative rehabilitative treatments performed on patients with Huntington’s disease. A search was performed on PubMed, Embase, Web of Science, and Cochrane databases to screen references of included studies and review articles for additional citations. Of an initial 1117 articles, only 20 met the search criteria. These findings showed that available evidence is still limited and that studies generally had small sample sizes and a high risk of bias. Regarding cognitive rehabilitation, it has emerged that VR- and PC-based methods as well as NIBS techniques are feasible and may have promising effects in individuals with Huntington’s disease. On the other hand, scarce evidence was found for cognitive and motor training that might have a slight impact on overall cognitive function in individuals with Huntington’s disease. Data show that further investigation is needed to explore the effects of innovative rehabilitation tools on cognition, especially considering that cognitive and psychiatric symptoms can precede the onset of motor symptoms by many years.

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Section: Discussionsupporting

confidence: 91%

The Role of Innovation Technology in the Rehabilitation of Patients Affected by Huntington’s Disease: A Scoping Review

Maggio,

Billeri,

Cardile

et al. 2023

Biomedicines

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Electrical stimulation of the ventromedial prefrontal cortex modulates muscle sympathetic nerve activity and blood pressure

Braun,

Patel,

Henderson

et al. 2023

Cerebral Cortex

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We recently showed that transcranial alternating current stimulation of the dorsolateral prefrontal cortex modulates spontaneous bursts of muscle sympathetic nerve activity, heart rate, and blood pressure (Sesa-Ashton G, Wong R, McCarthy B, Datta S, Henderson LA, Dawood T, Macefield VG. Stimulation of the dorsolateral prefrontal cortex modulates muscle sympathetic nerve activity and blood pressure in humans. Cereb Cortex Comm. 2022:3:2tgac017.). Stimulation was delivered between scalp electrodes placed over the nasion and electroencephalogram (EEG) electrode site F3 (left dorsolateral prefrontal cortex) or F4 (right dorsolateral prefrontal cortex), and therefore the current passed within the anatomical locations underlying the left and right ventromedial prefrontal cortices. Accordingly, we tested the hypothesis that stimulation of the left and right ventromedial prefrontal cortices would also modulate muscle sympathetic nerve activity, although we predicted that this would be weaker than that seen during dorsolateral prefrontal cortex stimulation. We further tested whether stimulation of the right ventromedial prefrontal cortices would cause greater modulation of muscle sympathetic nerve activity, than stimulation of the left ventromedial prefrontal cortices. In 11 individuals, muscle sympathetic nerve activity was recorded via microelectrodes inserted into the right common peroneal nerve, together with continuous blood pressure, electrocardiogram, and respiration. Stimulation was achieved using transcranial alternating current stimulation, +2 to −2 mA, 0.08 Hz, 100 cycles, applied between electrodes placed over the nasion, and EEG electrode site FP1, (left ventromedial prefrontal cortices) or FP2 (right ventromedial prefrontal cortices); for comparison, stimulation was also applied over F4 (right dorsolateral prefrontal cortex). Stimulation of all three cortical sites caused partial entrainment of muscle sympathetic nerve activity to the sinusoidal stimulation, together with modulation of blood pressure and heart rate. We found a significant fall in mean blood pressure of ~6 mmHg (P = 0.039) during stimulation of the left ventromedial prefrontal cortices, as compared with stimulation of the right. We have shown, for the first time, that transcranial alternating current stimulation of the ventromedial prefrontal cortices modulates muscle sympathetic nerve activity and blood pressure in awake humans at rest. However, it is unclear if this modulation occurred through the same brain pathways activated during transcranial alternating current stimulation of the dorsolateral prefrontal cortex.

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After-effects of Parieto-occipital Gamma Transcranial Alternating Current Stimulation on Behavioral Performance and Neural Activity in Visuo-spatial Attention Task

Zheng,

Huang,

Sugino

et al. 2024

Preprint

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Visuo-spatial attention enables selective focus on spatial locations while ignoring irrelevant stimuli which involves both endogenous and exogenous attention. Recent advancements in transcranial alternating current stimulation (tACS) have shown promise in modulating these attentional processes by targeting electrical oscillations in specific brain areas. Despite evidence of the online effects of tACS on the task performance of visuo-spatial attention, whether tACS can produce lasting after-effects on behavioral performance and neural activity during the visuo-spatial attention task remains unknown. This study aims to explore these after-effects on visuo-spatial attention by implementing a single-blind, sham-controlled, between-group experiment design. Twenty young and healthy participants were equally divided into two groups receiving either sham or active gamma tACS at 40 Hz targeted at the right parieto-occipital region. Each participant engaged in a version of the Posner cueing task, conducted with EEG recording before and after the tACS intervention. The results revealed that the active tACS group exhibited significant reductions in reaction time compared to the sham group. These changes were not uniform across different attention types, suggesting specific enhancements in cognitive processing. Additionally, EEG analysis showed that gamma tACS influenced various aspects of neural activity, including event-related potentials to the target, as well as the oscillatory power and long-range temporal correlations of EEG signal during the cue-target interval. The amplitude and latency of N1 and P3 components were modulated by gamma tACS. Notably, there was a decrease in alpha power and an increase in gamma power during the cue-target interval, alongside a decrease in long-range temporal correlations. These findings revealed the after-effect of gamma tACS on modulating the behavioral performance and neural activity in the visuo-spatial attention task, paving the way for future applications in cognitive enhancement and therapeutic interventions.

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Effects of medial prefrontal transcranial alternating current stimulation on neural activity and connectivity in people with Huntington’s disease and neurotypical controls

Cited by 5 publications

References 105 publications

The Role of Innovation Technology in the Rehabilitation of Patients Affected by Huntington’s Disease: A Scoping Review

The Role of Innovation Technology in the Rehabilitation of Patients Affected by Huntington’s Disease: A Scoping Review

Electrical stimulation of the ventromedial prefrontal cortex modulates muscle sympathetic nerve activity and blood pressure

After-effects of Parieto-occipital Gamma Transcranial Alternating Current Stimulation on Behavioral Performance and Neural Activity in Visuo-spatial Attention Task

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