Effects of melatonin implants on plasma concentrations of testosterone, thyroxine and prolactin in the male silver fox (Vulpes vulpes)

Forsberg, M.; Madej, Andrzej

doi:10.1530/jrf.0.0890351

Cited by 27 publications

(13 citation statements)

References 32 publications

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“…The release of melatonin from the implant is continuous and does not follow the diurnal rhythm of endogenous melatonin. Moreover, measurements of melatonin in blood plasma of implanted raccoon dogs (7) and silver foxes (27) show that the implants are capable of maintaining supraphysiological plasma levels of this hormone, several times exceeding endogenous concentration. They may reflect an increase in the endogenous secretion and/or a change in the metabolic clearance of the hormone.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the antioxidant system response to melatonin implant in raccoon dog (Nyctereutes procyonoides) and silver fox (Vulpes vulpes)

SERGINA¹,

BAISHNIKOVA²,

ILYUKHA³

et al. 2013

Turk J Vet Anim Sci

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Section: Discussionmentioning

confidence: 99%

“…They may reflect an increase in the endogenous secretion and/or a change in the metabolic clearance of the hormone. Such an increase or change would indicate that the constant supply of melatonin from the implant does not block the endogenous secretion of melatonin (27).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the antioxidant system response to melatonin implant in raccoon dog (Nyctereutes procyonoides) and silver fox (Vulpes vulpes)

SERGINA¹,

BAISHNIKOVA²,

ILYUKHA³

et al. 2013

Turk J Vet Anim Sci

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“…The detection limit of the assay was 0.5 nmol/litre. Plasma prolactin was measured by a homologous dog prolactin radioimmunoassay, as described by Forsberg and Madej (1990). The assay utilised radioiodinated dog prolactin (AFP-2451B), antiserum against dog prolactin (AFP-16111778) at a final dilution L of 1:87,500 and dog prolactin (NIADDK cPRL-RP-1, AFP-2451B) as standard.…”

Section: Methodsmentioning

confidence: 99%

Termination of mid‐term pregnancy in the dog with oral RU 486

Linde‐Forsberg¹,

Kindahl²,

Madej

1992

J of Small Animal Practice

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A total of four pregnancies were terminated in three bitches (two beagles and one flatcoated retriever) with a single dose of 20 mg/kg (one case), two doses of 8‐3 mg/kg (one case) or 20 mg/kg plus 40 mg/kg (two cases) RU 486 by mouth (Mifepristone; Roussel‐Uclaf, France) from day 26 to day 36 after the first day of mating of the bitch. Abortions occurred within two, four, 11 and 11 days after the initial treatment, respectively. The clinical status of the bitches was similar to that observed during a normal parturition, ie, lowering of the body temperature, shivering, panting and nesting behaviour. No side effects were seen. The beagle bitch that aborted twice, was mated at the first oestrus after the first abortion, conceived and aborted the same number of puppies the second time. The peripheral plasma progesterone concentration at the time of treatment in all bitches was < 75 nmol/litre. It had decreased to between 24‐2 and 13‐1 nmol/litre at the time of abortion and to between 4‐0 to 0–5 nmol/litre at four to 15 days after the initial treatment. Peripheral plasma levels of prolactin increased three‐ to fourfold within 24 to 48 hours after treatment, concomitant with the drop in progesterone and had returned to basal levels within two to three days. Prolactin concentrations also increased around the time of intrauterine fetal death. Prostaglandin F2aα‐metabolite concentrations increased slowly after treatment, and around the time of abortion the levels increased five‐ to 10‐fold. RU 486 seems to be a safe and effective abortifacient for use during mid‐term pregnancy in the dog.

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“…No samples were taken from the untreated control dog on these occasions. Plasma testosterone, LH and prolactin were analysed by radioimmunoassays (Forsberg et al, 1989;Forsberg & Madej, 1990).…”

Section: Studymentioning

confidence: 99%

Effects of very high doses of human growth hormone (hGH) on the male reproductive system in the dog

Sjögren

Jönsson²,

Madej

et al. 2009

Andrologia

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Summary. The effects of very high doses of human growth hormone (hGH), pituitary derived or recombinant methionyl‐hGH, on the morphology of reproductive organs and on some hormones in the male dog are described. The studies were part of a toxicological documentation of hGH. A total of 18 male dogs aged 7.5–20.5 months, from four studies were treated subcutaneously with hGH for 20–28 days at dose levels of 3, 10 or 25 IU kg−1 day−1 or 1 IU kg−1 three times weekly. Plasma levels of luteinizing hormone (LH), testosterone and prolactin were determined in one study. Organ weighing, macroscopic and histopathologic examinations of male reproductive organs at the end of the treatment period were included in all studies. Treatment with 25 IU kg−1 day−1 resulted in reduction of testis and prostate weights, degeneration of germ cells and epithelial atrophy in the testis, degenerative changes in epididymis and reduced height of the prostatic epithelium. Similar, although less severe morphological changes were observed after treatment with 10 IU kg−1 day−1. Treatment with 25 IU kg−1 day−1 also caused a marked reduction of plasma prolactin, LH and testosterone levels. These results suggest that repeated administration of very high doses of hGH interferes with the hormonal regulation of the testis in the dog.—

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Effects of melatonin implants on plasma concentrations of testosterone, thyroxine and prolactin in the male silver fox (Vulpes vulpes)

Cited by 27 publications

References 32 publications

Comparison of the antioxidant system response to melatonin implant in raccoon dog (Nyctereutes procyonoides) and silver fox (Vulpes vulpes)

Comparison of the antioxidant system response to melatonin implant in raccoon dog (Nyctereutes procyonoides) and silver fox (Vulpes vulpes)

Termination of mid‐term pregnancy in the dog with oral RU 486

Effects of very high doses of human growth hormone (hGH) on the male reproductive system in the dog

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