2022
DOI: 10.3390/ijms23126731
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Effects of Melatonin on the Transcriptome of Human Granulosa Cells, Fertilization and Blastocyst Formation

Abstract: Melatonin is a promising reagent that can improve assisted reproductive technology (ART) outcomes in infertility patients. However, melatonin is not effective for all infertile patients, and it remains unclear for which patients melatonin would be effective. This study examined the effects of melatonin on ART outcomes and examined its mechanisms. Melatonin increased the fertilization rate in patients whose fertilization rates in the previous cycle were less than 50%, but not in patients whose fertilization rat… Show more

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Cited by 9 publications
(4 citation statements)
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“…Further protective effects of melatonin against various detrimental conditions in nonseasonal breeder as well as in humans has been well reported. [53][54][55] Hence, we intended to explore the molecular basis of BPSstimulated ovarian dysfunction and the protective actions of melatonin against it.…”
Section: Discussionmentioning
confidence: 99%
“…Further protective effects of melatonin against various detrimental conditions in nonseasonal breeder as well as in humans has been well reported. [53][54][55] Hence, we intended to explore the molecular basis of BPSstimulated ovarian dysfunction and the protective actions of melatonin against it.…”
Section: Discussionmentioning
confidence: 99%
“…Total RNA was isolated from the cultured cells with an RNeasy® Mini Kit with DNAse treatment (QIAGEN, Inc., Valencia, CA). RNA-sequence was performed as reported previously 59 61 . mRNA was purified with oligo dT beads (NEBNext Poly(A) mRNA magnet Isolation Module, New England Biolabs).…”
Section: Methodsmentioning
confidence: 99%
“…The therapeutic applications of melatonin in clinical practice are incredibly varied, even including improvements in assisted reproductive technology (ART) outcomes [ 17 ]. In this context, the article of Tamura and collaborators (2022) shows how melatonin alters the granulose cells transcriptome by modifying gene expression associated with the inhibition of cell death, T-cell activity, and the activation of steroidogenesis and angiogenesis.…”
mentioning
confidence: 99%
“…In this context, the article of Tamura and collaborators (2022) shows how melatonin alters the granulose cells transcriptome by modifying gene expression associated with the inhibition of cell death, T-cell activity, and the activation of steroidogenesis and angiogenesis. As a consequence of this, melatonin could improve the oocyte quality and increase the blastocyst formation rate in patients whose embryo development rates in the previous ART cycle were less than 50%, ultimately leading to better outcomes of their infertility treatments [ 17 ].…”
mentioning
confidence: 99%