Effects of meldonium on sexual performance, sperm motility, testes morphology and blood biochemical markers in boars

Bruveris, Z.; Antane, V.; Misane, Ilga; Rimeicans, J.; Lusis, I.; Auzāns, Alberts; Mangale, M.; Mednis, A.; Stonâns, Ilmars

doi:10.1016/j.anireprosci.2012.11.007

Cited by 9 publications

(7 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…13,70,71 Meldonium could also enhance physical performance by elevating testosterone levels. Bruveris et al 72 administrated 2 g of meldonium (diluted with 2-3 mL of water) with food to wild boars. This study revealed a significant increase in testosterone levels compared to before treatment, namely, an increase from 2.0 ng/mL (+0.6) to 3.4 ng/mL (+ 0.7).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, further studies should be performed. 72 In addition to effects related to exercise, a study demonstrated the beneficial effects of meldonium on the vasodilatory capacity of atrial conduction vessels and resistance vessels and during static muscle loading with the static load tolerance test. This study reported that the combination of meldonium and lisinopril improves quality of life, exercise capacity, and peripheral circulation mechanisms compared to lisinopril.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Meldonium: Pharmacological, toxicological, and analytical aspects

Berlato

Bairros

2020

Toxicology Research and Application

View full text Add to dashboard Cite

Meldonium is the active molecule from Mildronate® with similar chemical structure to an amino acid, and it is known as (3-(2,2,2-trimethylhydrazine) propionate) (CAS 76144-81-5). This pharmaceutical substance is approved in Eastern Europe for cerebral and myocardial ischemia and has been on the World Doping Association’s banned substances list since January 2016. The goal of this review is to relate the use of meldonium as a doping agent, considering its pharmacological, toxicological, and analytical aspects. This review is based on the scientific literature from digital platforms. The main mechanism of action of meldonium is based on a decrease in l-carnitine levels and increase of peroxisomes activity in the cytosol. Females were more susceptible to the substance in animal experiments for toxicological tests. There is currently no report in the scientific literature about acute or chronic intoxication cases by meldonium in humans. Based on the literature findings, meldonium showed ergogenic effect in animals and human volunteers. For anti-doping analysis, urine is the biological matrix of choice, and dilute-and-shoot is the most common sample treatment in addition to liquid chromatography–mass spectrometry analysis. Other approaches could be used to determine meldonium levels, mainly for screening tests, such as l-carnitine or gamma-butyrobetaine levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Meldonium: Pharmacological, toxicological, and analytical aspects

Berlato

Bairros

2020

Toxicology Research and Application

View full text Add to dashboard Cite

show abstract

“…The diameters of each cross-section were measured using the Image Pro-Plus software at 200 × magnification in 10 randomly selected visual fields. The numbers of Leydig 51,52 , germ, and Sertoli cells 13,53 were also determined in 10 visual fields at 200 × magnification at each cross-section. Daily sperm production counts were estimated by a histometric method based on round spermatids 54,55 .…”

Section: Methodsmentioning

confidence: 99%

Maternal energy insufficiency affects testicular development of the offspring in a swine model

Lin

et al. 2019

Sci Rep

View full text Add to dashboard Cite

We determined the effects of insufficient maternal energy on testicular development in offspring in a swine model. Thirty-six sows were divided into control (CON) and low-energy diet (LE) groups during gestation. We observed that the number of Sertoli, germ, and Leydig cells in the offspring of the CON group were significantly higher than those in the LE group at 28 and 120 d after birth. Furthermore, the percentage of apoptotic testis cells was significantly higher in the offspring of the LE group than in the CON group. Transcriptome analysis of differentially expressed mRNAs and long noncoding RNAs in offspring testes indicated that these RNAs were mainly involved in lipid metabolism, apoptosis, cell proliferation, and some pivotal regulatory pathways. Results revealed that AMPK–PI3K–mTOR, MAPK, and oxidative phosphorylation signaling pathways play an important role in mediating the programming effect of insufficient maternal energy on testicular development, and that this effect occurs mainly at an early stage in life. mRNA and protein expression analyses confirmed the importance of certain signaling pathways in the regulation of testicular development. This study provides insights into the influence and possible mechanism underlying the effect of inadequate maternal energy intake on testicular development in the offspring.

show abstract

“…2 It was found to increase sperm motility, serum testosterone concentration and sexual performance in boar. 3 Later different clinical studies established it as an agent having anti-ischemic and cardio protective effect. 4,5 A large number studies had been carried out to explore its pharmacological effects and therapeutic benefits.…”

Section: Introductionmentioning

confidence: 99%

Meldonium: drug which brought disrepute to sport

Meher

Das

Mohanty

2017

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

World of sports have been rocked by doping scandals every now and then and World Anti-Doping Agency(WADA) has banned several offending drugs at different times to counter this menace. Meldonium is the recent addition to the long list of drugs banned by WADA to prevent its misuse among the athletes. Meldonium is a carnitine synthesis inhibitor and has been approved by some European countries for the management of cardiac diseases like angina pectoris and congestive cardiac failure. Apart from these, it has numerous other indications like bronchial asthma, bronchitis and retinopathies. It had also been used by athletes across the world because of its presumptive role in increasing the performance.

show abstract

Effects of meldonium on sexual performance, sperm motility, testes morphology and blood biochemical markers in boars

Cited by 9 publications

References 30 publications

Meldonium: Pharmacological, toxicological, and analytical aspects

Meldonium: Pharmacological, toxicological, and analytical aspects

Maternal energy insufficiency affects testicular development of the offspring in a swine model

Meldonium: drug which brought disrepute to sport

Contact Info

Product

Resources

About