Effects of membrane and flexural stiffnesses on aortic valve dynamics: Identifying the mechanics of leaflet flutter in thinner biological tissues

Johnson, Emily L.; Rajanna, Manoj R.; Yang, Cheng-Hau; Hsu, Ming‐Chen

doi:10.1016/j.finmec.2021.100053

Cited by 16 publications

(4 citation statements)

References 51 publications

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“…This is because thinner leaflets are characterized by a lower flexural rigidity, which is directly proportional to the thickness. 18 Flexural rigidity is a measurement of how much resistance to bending a component would oppose, with lower values indicating more flexible objects. As such, thin valves usually have wider orifices.…”

Section: Discussionmentioning

confidence: 99%

Bioinspired polymeric heart valves: A combined in vitro and in silico approach

Lee¹,

Liu²,

Giaretta³

et al. 2023

JTCVS Open

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Section: Discussionmentioning

confidence: 99%

Bioinspired polymeric heart valves: A combined in vitro and in silico approach

Lee¹,

Liu²,

Giaretta³

et al. 2023

JTCVS Open

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“…The results were compared with phase-contrast MRI data, in which a qualitative similarity of the flow pat-terns in the ascending aorta was found. More recently, the framework was applied to study leaflet flutter and its potentially damaging impact on the cardiac system due to the use of thinner, more flexible biological tissues in BHVs [100,205]. A model of a moving left ventricle was added to the heart-valve FSI framework in [101] to study the changes in the left ventricular hemodynamics following the BHV replacement of both aortic and mitral valves.…”

Section: Imgamentioning

confidence: 99%

Computational Cardiovascular Medicine With Isogeometric Analysis

Takizawa

Bazilevs

Tezduyar

et al. 2022

J. ADV. ENG. COMPUT.

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Isogeometric analysis (IGA) brought superior accuracy to computations in both fluid and solid mechanics. The increased accuracy has been in representing both the problem geometry and the variables computed. Beyond using IGA basis functions in space, with IGA basis functions in time in a space–time (ST) context, we can have increased accuracy also in representing the motion of solid surfaces. Around the core methods such as the residual-based variational multiscale (VMS), ST-VMS and arbitrary Lagrangian–Eulerian VMS methods, with complex-geometry IGA mesh generation methods and immersogeometric analysis, and with special methods targeting specific classes of computations, the IGA has been very effective in computational cardiovascular medicine. We provide an overview of these IGA-based computational cardiovascular-medicine methods and present examples of the computations performed.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.

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“…Saikrishnan et al 2012;Jahren et al 2018;Oechtering et al 2019;Lee et al 2020) and numerically (e.g. Borazjani 2013;Bavo et al 2016;de Tullio & Pascazio 2016;Hedayat et al 2017;Chen & Luo 2018;Gilmanov, Stolarski & Sotiropoulos 2018;Becsek et al 2020;Gallo, Morbiducci & de Tullio 2022;Johnson et al 2022;Asadi & Borazjani 2023).…”

Section: Introductionunclassified

“…Experimental as well as computational results have shown the influence of valve diameter and valve thickness on the fluttering frequency (Lee et al 2021). According to results of Johnson et al (2022), reduced flexural stiffness is considered a primary factor for increased leaflet flutter resulting in additional vortex formation in the valve vicinity, blood flow disturbance and an oscillatory pressure field. By varying the leaflet thickness, Chen & Luo (2020) investigated the impact of bending rigidity identifying an optimal range located between reduced rigidity resulting in flapping motion lowering the valve performance index and increased rigidity leading to hampered opening and closing as well as higher resistance.…”

Section: Introductionmentioning

confidence: 99%

Instability mechanisms initiating laminar–turbulent transition past bioprosthetic aortic valves

Bornemann,

Obrist

2024

J. Fluid Mech.

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Bioprosthetic heart valves create turbulent flow during early systole which might be detrimental to their durability and performance. Complex mechanisms in the unsteady and heterogeneous flow field complicate the isolation of specific instability mechanisms. We use linear stability analysis and numerical simulations of the flow in a simplified model to study mechanisms initiating the laminar–turbulent transition. The analysis of a modified Orr–Sommerfeld equation, which includes a model for fluid–structure interaction (FSI), indicates Kelvin–Helmholtz and FSI instabilities for a physiological Reynolds number regime. Two-dimensional parametrized FSI simulations confirm the growth rates and phase speeds of these instabilities. The eigenmodes associated with the observed leaflet kinematics allow for decoupled leaflet oscillations. A detailed analysis of the temporal evolution of the flow field shows that the starting vortex interacts with the aortic wall leading to a secondary vortex which moves towards the shear layer in the wake of the leaflets. This appears to be connected to the onset of the shear layer instabilities that are followed by the onset of leaflet motion leading to large-scale vortex shedding and eventually to a nonlinear breakdown of the flow. Numerical results further indicate that a narrower aorta leads to an earlier onset of the shear layer instabilities. They also suggest that the growing perturbations of the shear layer instability propagate upstream and may initiate the FSI instabilities on the valve leaflets.

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Effects of membrane and flexural stiffnesses on aortic valve dynamics: Identifying the mechanics of leaflet flutter in thinner biological tissues

Cited by 16 publications

References 51 publications

Bioinspired polymeric heart valves: A combined in vitro and in silico approach

Bioinspired polymeric heart valves: A combined in vitro and in silico approach

Computational Cardiovascular Medicine With Isogeometric Analysis

Instability mechanisms initiating laminar–turbulent transition past bioprosthetic aortic valves

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