Effects of menopause and hormone therapy on erythrocyte deformability

Sakashita, Tomohisa; Nobuzane, Takahiro; Mizumoto, Hiroshi; Fujiwara, Hisaya; Kudo, Yoshiki

doi:10.1097/gme.0b013e31818c9306

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…An intriguing report indicated that female rats had greater mesenteric nitric oxide production than males suggesting potential biological underpinnings for gender-specific iNOS-EIBS relationship(39). Alternatively, estrogens have been shown to impact on micro-circulation (coronary) directly or through alterations in RBC deformity(40). Since most women who develop CRC are post-menopausal (hence minimal ovarian estrogen secretion), we need to be circumspect about speculation on the role of sex hormones in EIBS.…”

Section: Discussionmentioning

confidence: 99%

Optical Measurement of Rectal Microvasculature as an Adjunct to Flexible Sigmoidosocopy: Gender-Specific Implications

Roy

Gomes

Ruderman

et al. 2010

Cancer Prevention Research

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Flexible sigmoidoscopy is a robust, clinically-validated and widely available colorectal cancer (CRC) screening technique that is currently sanctioned by both major guideline organizations. Given that endoscopic visualization is generally limited to the distal third of the colon and women tend to have a proclivity for proximal lesions, flexible sigmoidoscopy’s performance is markedly inferior in women than men. Our group has demonstrated that by using a novel light scattering approach we were able to detect an early increase in blood supply (EIBS) in the distal colonic mucosa which served as a marker of field carcinogenesis and hence proximal neoplasia. Therefore, we sought to ascertain whether rectal EIBS would improve flexible sigmoidoscopy, especially in women. A polarization-gated spectroscopy fiber-optic probe was utilized to assess EIBS in the endoscopically-normal rectum (n=366). When compared to gender-matched neoplasia-free controls, females with advanced proximal neoplasia (n=10) had a robust (60%, p=0.002) increase in rectal mucosal oxyhemoglobin (OHb) content (p = 0.001) whereas the effect size in males was less marked (33%, p=0.052). In women, addition of rectal OHb tripled the sensitivity for advanced neoplasia over flexible sigmoidoscopy alone. Indeed, the performance characteristics appeared to be excellent (sensitivity=100%, specificity=76.8%, positive predictive value =32.6% and negative predictive value of 100%). A variety of non-neoplastic factors were assessed and did not confound the relationship between rectal EIBS and advanced neoplasia. Therefore, using rectal EIBS in combination with flexible sigmoidoscopy mitigated the gender-gap and may allow flexible sigmoidoscopy to be considered a viable CRC screening test in women.

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Section: Discussionmentioning

confidence: 99%

Optical Measurement of Rectal Microvasculature as an Adjunct to Flexible Sigmoidosocopy: Gender-Specific Implications

Roy

Gomes

Ruderman

et al. 2010

Cancer Prevention Research

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Transient stress-related hyperviscosity and endothelial dysfunction in Takotsubo syndrome: a time course study

et al. 2022

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Prevalence of thrombophilic disorders in takotsubo patients: the (ThROmbophylia in TAkotsubo cardiomyopathy) TROTA study

et al. 2016

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Takotsubo cardiomyopathy (TTC) pathophysiology is still unclear. A transient intracoronary thrombosis dissolved at the time of angiography has been hypothesized. We aimed to evaluate the prevalence of thrombophilic disorders in TTC patients. In 75 TTC women, 75 age- and sex-matched acute coronary syndrome (ACS) patients, both enrolled during the acute phase, and in 75 control subjects, we compared the prevalence of congenital and acquired thrombophilic alterations and the values of clotting and endothelial activation biomarkers. Some parameters were re-assessed 1 month after the acute phase in TTC patients. No significant difference between the three groups was observed in factor II (G20210A) and V (G1691A) polymorphisms prevalence. Homocysteine levels were significantly higher in ACS patients vs. TTC and control subjects. Lipoprotein(a) values trended to be higher in TTC patients vs. control subjects, though not significantly. Other thrombophilic alterations in TTC patients were similar to that previously reported in healthy women. Von Willebrand factor and plasminogen activator inhibitor-1 were significantly higher in TTC and in ACS patients than controls. Clotting activation biomarkers were not statistically different between TTC patients and controls. During follow-up, in TTC patients, endothelial damage indices significantly decreased while clotting activation biomarkers remained unchanged. In conclusion, our results, showing a rate of thrombophilic alterations in TTC patients similar to control subjects, do not support the transient intracoronary thrombus hypothesis. However, several endothelial damage markers and lipoprotein(a) were higher in TTC patients vs. controls suggesting a role of endothelial dysfunction and of other factors concurring to hyperviscosity, as recently hypothesized.

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Effects of menopause and hormone therapy on erythrocyte deformability

Abstract: These results indicate that erythrocyte deformability may worsen with the decrease in the estrogen level because of the onset of menopause, and also suggest that ET and EPT may allow it to recover.

Cited by 4 publications

References 9 publications

Optical Measurement of Rectal Microvasculature as an Adjunct to Flexible Sigmoidosocopy: Gender-Specific Implications

Optical Measurement of Rectal Microvasculature as an Adjunct to Flexible Sigmoidosocopy: Gender-Specific Implications

Transient stress-related hyperviscosity and endothelial dysfunction in Takotsubo syndrome: a time course study

Prevalence of thrombophilic disorders in takotsubo patients: the (ThROmbophylia in TAkotsubo cardiomyopathy) TROTA study

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