2024
DOI: 10.2147/jpr.s491626
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Effects of Mental Disorders on Fibromyalgia Mediated by Insomnia: A Mendelian Randomization Study

Le Chang,
Zhen Sun,
Shiyong Zeng
et al.

Abstract: Background This study employed Mendelian randomization (MR) analysis to confirm the causal effects of mental disorders on fibromyalgia. Methods The summary data for exposures, mediator, and outcome were extracted from the GWAS catalog project, IEU openGWAS project, and Finn biobank database. Significantly associated and independent single-nucleotide polymorphisms (SNPs) meeting the criteria of p < 5×10−8, r2 < 0.001, and kb = 10,000 were selected for MR analysis. We use… Show more

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