Effects of meta-tetrahydroxyphenylchlorin photodynamic therapy on isogenic colorectal cancer SW480 and SW620 cells with different metastatic potentials

Abdulrehman, Gulinur; Xv, Kaiyue; Li, Yuhua; Kang, Ling

doi:10.1007/s10103-018-2524-7

Cited by 22 publications

(20 citation statements)

References 47 publications

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“…The first obvious answer is that PDT, in principle, may be effective against some cancers, based on results of experiments in-vitro, rodent models, and clinical studies. Examples of cancers, where encouraging results with PDT have been obtained in-vitro include breast cancer [11], oesophageal cancer [12], liver carcinoma [13], and colorectal cancer [14]. Further information on in-vivo application of PDT can be found elsewhere [15].…”

Section: Development Of the Concept Of Pdtmentioning

confidence: 99%

Using Light for Therapy of Glioblastoma Multiforme (GBM)

et al. 2020

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Glioblastoma multiforme (GBM) is the most malignant form of primary brain tumour with extremely poor prognosis. The current standard of care for newly diagnosed GBM includes maximal surgical resection followed by radiotherapy and adjuvant chemotherapy. The introduction of this protocol has improved overall survival, however recurrence is essentially inevitable. The key reason for that is that the surgical treatment fails to eradicate GBM cells completely, and adjacent parenchyma remains infiltrated by scattered GBM cells which become the source of recurrence. This stimulates interest to any supplementary methods which could help to destroy residual GBM cells and fight the infiltration. Photodynamic therapy (PDT) relies on photo-toxic effects induced by specific molecules (photosensitisers) upon absorption of photons from a light source. Such toxic effects are not specific to a particular molecular fingerprint of GBM, but rather depend on selective accumulation of the photosensitiser inside tumour cells or, perhaps their greater sensitivity to the effects, triggered by light. This gives hope that it might be possible to preferentially damage infiltrating GBM cells within the areas which cannot be surgically removed and further improve the chances of survival if an efficient photosensitiser and hardware for light delivery into the brain tissue are developed. So far, clinical trials with PDT were performed with one specific type of photosensitiser, protoporphyrin IX, which tends to accumulate in the cytoplasm of the GBM cells. In this review we discuss the idea that other types of molecules which build up in mitochondria could be explored as photosensitisers and used for PDT of these aggressive brain tumours.

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Section: Development Of the Concept Of Pdtmentioning

confidence: 99%

Using Light for Therapy of Glioblastoma Multiforme (GBM)

et al. 2020

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“…M-THPC and VP are two second-generation photosensitizers: m-THPC has been mainly used in the treatment of patients with head and neck cancer, while VP has been primarily used in the treatment of patients with age-related macular degeneration 40 , 41 . Recently, evidence has shown that m-THPC and VP exhibited excellent antitumor efficiency in CRC cells 16 , 42 . In this study, we found that m-THPC-PDT and VP-PDT had a strong phototoxic effect on CRC cells, as shown by decreased cell viability and increased ROS production.…”

Section: Discussionmentioning

confidence: 99%

“…PSs function as catalysts during the process of PDT 15 . Meta-tetrahydroxyphenylchlorin (m-THPC) and verteporfin (VP) are second-generation photosensitizers that exhibit considerable photocytotoxicity to various tumor cells 16 , 17 . Emerging studies have found that m-THPC-PDT and VP-PDT could be promising therapeutic candidates for the treatment of human cancers 18 , 19 .…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy induces autophagy-mediated cell death in human colorectal cancer cells via activation of the ROS/JNK signaling pathway

Song

et al. 2020

Cell Death Dis

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Evidence has shown that m-THPC and verteporfin (VP) are promising sensitizers in photodynamic therapy (PDT). In addition, autophagy can act as a tumor suppressor or a tumor promoter depending on the photosensitizer (PS) and the cancer cell type. However, the role of autophagy in m-THPC- and VP-mediated PDT in in vitro and in vivo models of human colorectal cancer (CRC) has not been reported. In this study, m-THPC-PDT or VP-PDT exhibited significant phototoxicity, inhibited proliferation, and induced the generation of large amounts of reactive oxygen species (ROS) in CRC cells. From immunoblotting, fluorescence image analysis, and transmission electron microscopy, we found extensive autophagic activation induced by ROS in cells. In addition, m-THPC-PDT or VP-PDT treatment significantly induced apoptosis in CRC cells. Interestingly, the inhibition of m-THPC-PDT-induced autophagy by knockdown of ATG5 or ATG7 substantially inhibited the apoptosis of CRC cells. Moreover, m-THPC-PDT treatment inhibited tumorigenesis of subcutaneous HCT116 xenografts. Meanwhile, antioxidant treatment markedly inhibited autophagy and apoptosis induced by PDT in CRC cells by inactivating JNK signaling. In conclusion, inhibition of autophagy can remarkably alleviate PDT-mediated anticancer efficiency in CRC cells via inactivation of the ROS/JNK signaling pathway. Our study provides evidence for the therapeutic application of m-THPC and VP in CRC.

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“…2,10 CRC arises from benign adenomatous polyps in the colon. 1,2 When polyps become cancerous, they become full-blown tumors on the wall of the colon and later protrude outwards into the intestinal lumen. 11,12 These outward protruding tumors can then also spread further into the cardiovascular or lymphatic system, as well as to other tissues or organs of the body, resulting in secondary cancer metastasis.…”

Section: Colorectal Cancermentioning

confidence: 99%

“…Colorectal cancer (CRC) frequently emerges from precancerous polyps that are initially conned in the innermost mucosal layers of the colon. 1,2 This devastating disease is recognized amongst the most prevalent malignancies and can be considered as the second leading cause of tumor-associated deaths in women and the third most common in men worldwide. 3 Recent projections have indicated that by 2030, the incidence and mortality rate of CRC will increase by 60% globally.…”

Section: Introductionmentioning

confidence: 99%