Effects of Metabolic Syndrome and Findings From Baseline Colonoscopies on Occurrence of Colorectal Neoplasms

Chiu, Han–Mo; Lee, Yi–Chia; Tu, Chia‐Hung; Chang, Li-Chun; Hsu, Wen‐Feng; Chou, Chia-Hung; Tsai, Kun-Feng; Liang, Jin–Tung; Shun, Chia‐Tung

doi:10.1016/j.cgh.2014.10.022

Cited by 44 publications

(67 citation statements)

References 28 publications

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“…As the surveillance colonoscopy interval was shorter in the high‐risk group, the time might not have been sufficient for the waist circumference to influence CRN occurrence in this group. This assumption can be further supported by a recent study in which surveillance intervals were recommended as current guidelines . The authors of that study reported a positive effect of metabolic syndrome detected at the time of baseline colonoscopy on advanced CRN occurrence at the time of surveillance colonoscopy in their normal and low‐risk patient groups, but not in the high‐risk group.…”

Section: Discussionmentioning

confidence: 56%

“…This assumption can be further supported by a recent study in which surveillance intervals were recommended as current guidelines. 16 The authors of that study reported a positive effect of metabolic syndrome detected at the time of baseline colonoscopy on advanced CRN occurrence at the time of surveillance colonoscopy in their normal and low-risk patient groups, but not in the high-risk group. Putting these findings together with our results, we suggest metabolic factors may affect advanced CRN occurrence through a long exposure period.…”

Section: Figurementioning

confidence: 98%

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Metabolic factors affect the occurrence of colorectal neoplasm on surveillance colonoscopies

Han

Park

et al. 2016

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 56%

Section: Figurementioning

confidence: 98%

Metabolic factors affect the occurrence of colorectal neoplasm on surveillance colonoscopies

Han

Park

et al. 2016

J of Gastro and Hepatol

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“…Physiologically, insulin resistance is markedly reduced in RYGB and gastric sleeve procedures in the immediate postoperative period. 25, 26 Insulin resistance has been linked to an increased rate of advanced adenomas 27 through activation of the insulin–insulin-like growth factor signaling axis—which can upregulate Wnt signaling, expression of antiapoptotic proteins, and Akt protein activation. 28 Adiponectin, a systemic adipokine, is increased after RYGB.…”

Section: Discussionmentioning

confidence: 99%

Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals

Kedrin

Gandhi

Wolf

et al. 2017

Clinical and Translational Gastroenterology

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Objectives:Obesity is an important risk factor for the development of colorectal cancer (CRC). Although the impact of bariatric surgery on CRC is conflicting, its impact on precursor lesions is unknown. The aim of this study was to determine whether bariatric surgery before index screening colonoscopy is associated with decreased development of colorectal adenomas.Methods:We performed a retrospective cohort study of bariatric surgery patients who had undergone index, screening colonoscopy at an academic center from 2001 to 2014. Patients who had bariatric surgery at least 1 year before index colonoscopy were compared with those who had surgery after colonoscopy, using multivariable logistic regression to control for presurgical body mass index, sex, gender, race, type of surgery, aspirin use, metformin use, smoking, and age at colonoscopy.Results:One hundred and twenty-five obese individuals who had bariatric surgery before colonoscopy were compared with 223 individuals who had colonoscopy after surgery. Adenomatous polyps were found in 16.8% of individuals who had surgery first vs. 35.5% who had colonoscopy before bariatric surgery (unadjusted odds ratio (OR) 0.37, 95% confidence interval (CI): 0.21–0.64, P=0.0003). After multivariable adjustment, bariatric surgery before index screening colonoscopy was associated with a decreased risk of adenomas at index colonoscopy (adjusted OR 0.37, 95% CI: 0.19–0.69, P=0.002).Conclusions:Bariatric surgery is associated with a decreased risk of colorectal adenomas in obese individuals without a family history of CRC.

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“…Integrated risk profiles can be considered to personalize surveillance intervals. As such, Chiu et al . showed that the metabolic syndrome is a risk factor for developing advanced neoplasms in patients at low risk and in those without neoplasms at baseline examination.…”

Section: Detection and Resection Of Colorectal Neoplasmsmentioning

confidence: 99%

Optimizing post‐polypectomy surveillance: A practical guide for the endoscopist

Bogie

Sanduleanu

2015

Digestive Endoscopy

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Several gastrointestinal societies strongly recommend colonoscopy surveillance after endoscopic and surgical resection of colorectal neoplasms. Common denominators to these recommendations include: high-quality baseline colonoscopy before inclusion in a surveillance program; risk stratification based on clinicopathological profiles to guide surveillance intervals; and endoscopist responsibility for providing surveillance advice. Considerable variability also exists between guidelines (i.e. regarding risk classification and surveillance intervals). In this review, we examine key factors for quality of post-polypectomy surveillance practice, in particular bowel preparation, endoscopic findings at baseline examination and adherence to surveillance recommendations. Frequently asked questions by the practising endoscopist are addressed.

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Effects of Metabolic Syndrome and Findings From Baseline Colonoscopies on Occurrence of Colorectal Neoplasms

Cited by 44 publications

References 28 publications

Metabolic factors affect the occurrence of colorectal neoplasm on surveillance colonoscopies

Metabolic factors affect the occurrence of colorectal neoplasm on surveillance colonoscopies

Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals

Optimizing post‐polypectomy surveillance: A practical guide for the endoscopist

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