Effects of metaproterenol on pulmonary mechanics, oxygenation, and ventilation in infants with chronic lung disease

Cabal, Luis A; Larrazabal, Carlos; Ramanathan, Rangasamy; Durand, Manuel; Lewis, Donald J.; Siassi, Bijan; Hodgman, Joan E.

doi:10.1016/s0022-3476(87)80302-5

Cited by 56 publications

(24 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Airway responsiveness and improvement in pulmonary function after bronchodilator nebulization recently have been demon strated in a number of studies of infants with chronic lung disease [7][8][9][10][11][12], Our findings confirm, that some preterm infants can re spond to ß-agonists with resultant improve ments in tidal volume and compliance. However, similar to findings of Rotschild et al [12], we did not see a consistent decrease in airway resistance when improvement oc curred in tidal volume and compliance.…”

Section: Discussionsupporting

confidence: 77%

See 1 more Smart Citation

Use of a Beta-Agonist in Ventilated, Very-Low-Birth-Weight Babies: A Longitudinal Evaluation

Kovacs¹,

Fisher²,

Brodsky³

et al. 1990

Dev Pharmacol Ther

View full text Add to dashboard Cite

To determine if there is a specific postnatal (PNA) or postconceptional age (PCA) at which ventilated preterm infants respond to β-agonists, we evaluated 15 infants with a mean gestational age of 26.5 ± 1.5 weeks and mean birth weight of 0.89 ± 0.23 kg who required mechanical ventilation at 10 days of age. Weekly pulmonary function testing (PFT) was performed before and 1 h after administration of albuterol. Taking the group as a whole, as well as individual babies, regression analysis showed no relationship between positive response and either PNA or PCA. Evaluation of individual infants, however, showed that some consistently responded to ß-agonists whereas others did not. We recommend individual PFT to identify those infants who will benefit from use of β-agonists.

show abstract

Section: Discussionsupporting

confidence: 77%

“…In summary, we feel that this PFT procedure provides useful information in even the most criti cally ill children. Other investigators have used techniques involving sedation or paral ysis [10] that may produce undesirable side effects.…”

Section: Discussionmentioning

confidence: 99%

Use of a Beta-Agonist in Ventilated, Very-Low-Birth-Weight Babies: A Longitudinal Evaluation

Kovacs¹,

Fisher²,

Brodsky³

et al. 1990

Dev Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…However, in the present study there was no improvement in pulmonary resistance after inhalation of bronchodilators. Many studies have evaluated the response to bronchodilators in very early BPD when [2,3,7,9,17,21]. In these ventilated babies improvement of pulmonary compliance and airway resistance has been reported after beta mimetic and anticholinergic drugs but also after administration of caeine [18], aminophylline [8] and diuretics [4].…”

Section: Discussionmentioning

confidence: 99%

“…In patients with BPD, an improvement in pulmonary mechanics after administration of bronchodilators has been well documented in the acute stage of the disease [2,3,7,9,17,21]. Therefore it has been suggested that long-term treatment with bronchodilators may be bene®cial [2,5,7,17].…”

Section: Introductionmentioning

confidence: 99%

Response to bronchodilators in clinically stable 1-year-old patients with bronchopulmonary dysplasia

Boeck¹,

Smith²,

Lierde³

et al. 1998

Eur J Pediatr

View full text Add to dashboard Cite

show abstract

“…Inhaled bronchodilator therapy improves lung function and blood gases in ventilated 1-month-old babies with BPD [95]. Salbutamol resulted in a dose-dependent improvement in lung mechanics [96].…”

Section: Bronchodilatorsmentioning

confidence: 99%

Medicines used in respiratory diseases only seen in children

Lenney¹,

Al²,

Bont³

et al. 2009

Eur Respir J

View full text Add to dashboard Cite

Detailed literature searches were carried out in seven respiratory disease areas. Therapeutic evidence for efficacy of medicinal products was assessed using the Grades of Recommendation, Assessment and Evaluation (GRADE) methodology, as well as an assessment of safety and side-effects.Systemic corticosteroids may reduce the development of bronchopulmonary dysplasia but have serious side-effects. Antioxidants need further study to demonstrate whether they have long-term benefits. Treatments for acute bronchiolitis have shown little benefit but new antiviral and monoclonal antibodies need further assessment. Well-constructed studies are needed to confirm the value of inhaled corticosteroids and/or montelukast in the management of viralinduced wheeze. Corticosteroids are the treatment of choice in croup. Minimal or no information is available for the treatment of congenital lung abnormalities, bronchiolitis obliterans and interstitial lung disease.

show abstract

Effects of metaproterenol on pulmonary mechanics, oxygenation, and ventilation in infants with chronic lung disease

Cited by 56 publications

References 9 publications

Use of a Beta-Agonist in Ventilated, Very-Low-Birth-Weight Babies: A Longitudinal Evaluation

Use of a Beta-Agonist in Ventilated, Very-Low-Birth-Weight Babies: A Longitudinal Evaluation

Response to bronchodilators in clinically stable 1-year-old patients with bronchopulmonary dysplasia

Medicines used in respiratory diseases only seen in children

Contact Info

Product

Resources

About