Effects of metformin on lipopolysaccharide induced inflammation by activating fibroblast growth factor 21

Kar, Ezgi; Alataş, Özkaņ; Şahıntürk, Varol; Öz, Semih

doi:10.1080/10520295.2021.1894353

Cited by 6 publications

(8 citation statements)

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“…Thus, FGF21 may be a potential biomarker for sepsis patients’ survival prediction. FGF21 is also required for controlling the inflammation of metformin through suppressing pro-inflammatory cytokines and enhancing anti-inflammatory cytokines in rat liver induced by LPS ( 89 ). The relationship between increased expression of FGF21 and sepsis may be explained by these findings.…”

Section: The Role Of Fibroblast Growth Factor 21 In Sepsis and Septic...mentioning

confidence: 99%

Emerging roles of fibroblast growth factor 21 in critical disease

Fang

Li²,

Yang³

et al. 2022

Front. Cardiovasc. Med.

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In spite of the great progress in the management of critical diseases in recent years, its associated prevalence and mortality of multiple organ failure still remain high. As an endocrine hormone, fibroblast growth factor 21 (FGF21) functions to maintain homeostasis in the whole body. Recent studies have proved that FGF21 has promising potential effects in critical diseases. FGF21 has also been found to have a close relationship with the progression of critical diseases and has a great predictive function for organ failure. The level of FGF21 was elevated in both mouse models and human patients with sepsis or other critical illnesses. Moreover, it is a promising biomarker and has certain therapeutic roles in some critical diseases. We focus on the emerging roles of FGF21 and its potential effects in critical diseases including acute lung injury/acute respiratory distress syndrome (ALI/ARDS), acute myocardial injury (AMI), acute kidney injury (AKI), sepsis, and liver failure in this review. FGF21 has high application value and is worth further studying. Focusing on FGF21 may provide a new perspective for the management of the critical diseases.

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Section: The Role Of Fibroblast Growth Factor 21 In Sepsis and Septic...mentioning

confidence: 99%

Emerging roles of fibroblast growth factor 21 in critical disease

Fang

Li²,

Yang³

et al. 2022

Front. Cardiovasc. Med.

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“…In an animal model with male rats, high‐dose LPS (5 mg/kg) was applied and induced severe hepatic injury. 54 The injection of LPS induced hepatic production of FGF21 and increased serum concentrations. Administration of metformin, an anti‐diabetic drug with anti‐inflammatory effects through the inhibition of nuclear factor kappa B (NF‐κB) via the adenosine‐monophosphate (AMP)‐activated‐protein‐kinase (AMPK) pathway 55 , 56 and the induction of interleukin‐4 and interleukin‐10, 57 markedly reduced inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, metformin appears to stimulate hepatic FGF21 production. 54 The authors suggest that FGF21 and metformin together have a liver‐protective impact through anti‐inflammatory effects. 54 …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, metformin appears to stimulate hepatic FGF21 production. 54 The authors suggest that FGF21 and metformin together have a liver-protective impact through anti-inflammatory effects. 54 Moreover, it was demonstrated in male mice that FGF21 directly influences the polarization of macrophages.…”

Section: Et Al Reported Increased Fgf21 Plasma Concentrations In Insu...mentioning

confidence: 99%

“…54 The authors suggest that FGF21 and metformin together have a liver-protective impact through anti-inflammatory effects. 54 Moreover, it was demonstrated in male mice that FGF21 directly influences the polarization of macrophages. LPS induces the differentiation into proinflammatory M1 macrophages, whereas FGF21 causes a reduction of M1 markers towards the development of anti-inflammatory M2 macrophages.…”

Section: Et Al Reported Increased Fgf21 Plasma Concentrations In Insu...mentioning

confidence: 99%

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Glucose and lipopolysaccharide differentially regulate fibroblast growth factor 21 in healthy male human volunteers – A prospective cross‐over trial

Pohlhammer

Heinzl

Klammer

et al. 2022

J Cellular Molecular Medi

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Fibroblast growth factor 21 (FGF21) affects the regulation of metabolism. Additionally, anti‐inflammatory properties are attributed to FGF21, and studies in animals and humans show conflicting results. This study aimed to investigate how FGF21 is affected by glucose and lipopolysaccharide (LPS) in humans. Therefore, FGF21 was measured eight times at different time points within 48 h in this prospective cross‐over trial after glucose and LPS on two different study days. The study included ten healthy, non‐smoking male subjects aged 18–40. Repeated measures analysis of variance and paired t‐test as post hoc analysis were applied. The administration of glucose and LPS resulted in a significant difference in regulating FGF21 (p < 0.001). After glucose administration, FGF21 declined sharply at 360 min, with a subsequent steep increase that exceeded baseline levels. LPS induced a drop in FGF21 after 180 min, while the baseline concentrations were not reached. After 180 min and 24 h, a statistically significant difference was demonstrated after adjusting the Bonferroni–Holm method. So, our results support the hypothesis that glucose and LPS differentially affect the human expression of FGF21 over 48 h.

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