Effects of methamphetamine and ethanol on learning and brain neurotransmitters in rats

Yamamura, Takeshi; Hishida, Shigeru; Hatake, Kiyohiko; Taniguchi, Tadaaki; Ouchi, Harumi

doi:10.1016/0091-3057(92)90131-x

Cited by 18 publications

(10 citation statements)

References 36 publications

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“…However, this experimental group still demonstrated impaired retention when compared with saline-treated animals. These results are in line with other studies showing that repeated treatment with amphetamine, or methamphetamine, induces performance impairments in learning/memory animal models (Bruto et al 1983;Yamamura et al 1992). Accordingly, amphetamine abusers have been reported to present several kinds of memory impairment, considered to be a result of amphetamine neurotoxicity (McKetin and Mattick 1998;Ornstein et al 2000).…”

Section: Discussionsupporting

confidence: 92%

“…Accordingly, amphetamine abusers have been reported to present several kinds of memory impairment, considered to be a result of amphetamine neurotoxicity (McKetin and Mattick 1998;Ornstein et al 2000). In this respect, it has been suggested that chronic methamphetamine-induced damages on learning/memory are related to the important alterations in dopamine turnover promoted by this drug, which were still present 11 days after methamphetamine withdrawal (Yamamura et al 1992). Although less toxic than methamphetamine, amphetamine has a similar pharmacological profile (Hotchkiss and Gib 1980), and this same mechanism could be underlying the effects reported here.…”

Section: Discussionmentioning

confidence: 97%

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Effects of amphetamine on the plus-maze discriminative avoidance task in mice

et al. 2002

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Amphetamine has different effects on DAT when given pre- or post-training. While acute pre-training amnestic action is temporally correlated with an anxiogenic effect, there is tolerance to the anxiogenic but not to the amnestic effect after repeated administration. Because this acute amnestic effect of amphetamine is attenuated by tacrine, a possible relationship with cholinergic system cannot be discarded as a mechanism to amphetamine-induced amnesia in DAT.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Effects of amphetamine on the plus-maze discriminative avoidance task in mice

et al. 2002

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“…In our study, in line with others [69][70][71], moderate-dose AL alone caused no evident impact on spatial learning and memory while MA and AL co-administration produced a profile of effects similar to, but more severe than, those caused by MA alone. In accordance with the present results, previous studies have shown synergistic disruption of cognitive function by coadministration of MA and AL in both animals and humans [72,73]. It is well documented that spatial memory is dependent on the integrity of the hippocampus [74], and damage to this region, thus impairs its role in spatial learning and memory [68].…”

Section: Effect Of Ma And/or Al On Spatial Learning and Memory And Oxsupporting

confidence: 92%

The Effect of Escalating Dose, Multiple Binge Methamphetamine Regimen and Alcohol Combination on Spatial Memory and Oxidative Stress Markers in Rat Brain

M¹

2014

J Alcohol Drug Depend

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Polydrug abuse is a major problem around the world. Methamphetamine (MA) and alcohol (AL) are two abused drugs which are frequently used together. Chronic abuse of either MA or AL causes oxidative stress in the brain and is associated with impairments in cognitive functions including various aspects of memory and learning. The present study examined the effect of escalating dose, multiple binge MA regimen, AL and MA-AL combination on spatial memory and the induction of oxidative stress in the hippocampus. Adult male Wistar rats were exposed to ethanol, an escalating dose of MA either individually or in combination for 28 consecutive days. In order to examine the short-and long-term effects of chronic exposure to the drugs, each group was then subdivided into two further groups. Thereafter, spatial memory was tested using a Morris water maze, either one day or 14 days after the drugs were withdrawn. At the end of the behavioral testing, oxidative stress markers including Superoxide Dismutase (SOD), Glutathione Peroxidase (GPX), Catalase (CAT), and Malondialdehyde (MDA) were measured. Our results showed that MA, but not AL, impaired spatial memory. Although AL alone had no effect, it exacerbated the impairment due to MA when the drugs were co-administered. In addition, while both drugs significantly induced oxidative stress in the hippocampus when given alone, co-administration of these drugs resulted in a greater oxidative stress and an impairment of the antioxidant enzyme glutathione peroxidase in rat hippocampus. Taken together, this study demonstrates that MA in combination with AL has synergistic effects on increased oxidative stress in the hippocampus, as well as spatial memory impairment.

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“…One of the most popular recreational drugs besides cannabis in the Central Europe DOI 10.2478/v10219-012-0026-4 Brought to you by | Masaryk University et al, 2011). The combination is also more potent in causing memory impairment in rats than administration of single drugs (Yamamura et al, 1992). The molecular mechanism of these behavioural effects is probably carried by different changes on dopamine and serotonin release, which are dependent not only on the substance, but may also vary between rat strains (Nishiguchi et al, 2002, Yamauchi et al, 2000.…”

mentioning

confidence: 99%

“…The experiments focused on the behavioural aspects of ET and METH combination documented, that ET accentuates the METH neurotoxicity, and both of them are evoking anxiolytic effects in rats (Chuang et al, 2011). The combination is also more potent in causing memory impairment in rats than administration of single drugs (Yamamura et al, 1992). The molecular mechanism of these behavioural effects is probably carried by different changes on dopamine and serotonin release, which are dependent not only on the substance, but may also vary between rat strains (Nishiguchi et al, 2002, Yamauchi et al, 2000.…”

mentioning

confidence: 99%

The Effect of Methamphetamine on Biotransformation of Ethanol: Pilot Study

Zendulka¹,

Sabová²,

Juřica³

et al. 2012

Acta Facultatis Pharmaceuticae Universitatis Comenianae

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Methamphetamine is one of the most popular recreational drugs in Central Europe and is often combined with ethanol. Various interactions between these two substances have been described including the influence of administered ethanol on biotransformation of methamphetamine. The aim of the present study was to describe the opposite effectthe influence of methamphetamine on biotransformation of ethanol in rats. Methamphetamine was administered for 10 days (10 mg/kg/day) i.p. and ethanol was delivered as an intragastric bolus (2 g/kg) on the10 th day of experiment to both methamphetamine administered rats and control animals. The pharmacokinetic experiment on the whole animal was performed and plasma samples were drawn at the 40 th , 120 th , 210 th and 300 th minute after ethanol administration. Ethanol plasmatic levels reached significantly lower values in the 40 th and 120 th interval when compared to controls. Differences were insignificant in the last two intervals. Our results suggest that chronic methamphetamine administration induces ethanol biotransformation. We suppose that this effect is caused by induction of alcohol dehydrogenase metabolic activity or by allosteric interaction of methamphetamine and this enzyme. More studies have to be conducted to confirm or disprove our hypothesis. Keywords: methamphetamine -ethanol -biotransformation -interaction -rat INTRODUCTIONSubstance abuse is as old as mankind, and brings together health and social problems affecting both the abuser and the society as well. Drugs of abuse are miscellaneous substances eliciting different biologic effects, and their misuse is usually region-specific due to differences in their availability, legislation, and social conditions in the specific area. One of the most popular recreational drugs besides cannabis in the Central Europe DOI 10.2478/v10219-012-0026-4 Brought to you by | Masaryk University et al., 2011). The combination is also more potent in causing memory impairment in rats than administration of single drugs (Yamamura et al., 1992). The molecular mechanism of these behavioural effects is probably carried by different changes on dopamine and serotonin release, which are dependent not only on the substance, but may also vary between rat strains (Nishiguchi et al., 2002, Yamauchi et al., 2000. The chronic administration of METH alone could increase the ET intake in mice because of induction of long term dopaminergic toxicity, and hypodopaminergic state is described to increase the voluntary ET consumption (Gutierrez-Lopez et al., 2010).Preclinical experiments aimed on pharmacokinetic interactions of ET and METH describe the inhibition of METH metabolism when combined with ET (Liang et al., 2012). Increase in the METH plasmatic levels is due to inhibition of METH Ndemethylation and parahydroxylation (Yamada et al., 2001) caused by ET. The similar result was confirmed in humans, too (Shimosato, 1988), whereas other clinical trial with ET and METH combination did not discover any change in METH levels among subjects (Mende...

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Effects of methamphetamine and ethanol on learning and brain neurotransmitters in rats

Cited by 18 publications

References 36 publications

Effects of amphetamine on the plus-maze discriminative avoidance task in mice

Effects of amphetamine on the plus-maze discriminative avoidance task in mice

The Effect of Escalating Dose, Multiple Binge Methamphetamine Regimen and Alcohol Combination on Spatial Memory and Oxidative Stress Markers in Rat Brain

The Effect of Methamphetamine on Biotransformation of Ethanol: Pilot Study

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