Effects of methamphetamine on novelty-seeking behaviour by mice

Misslin, René; Ropartz, P

doi:10.1007/bf00433499

Cited by 60 publications

(28 citation statements)

References 21 publications

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“…As expected on the basis of previous reports (Misslin and Ropartz 1981;Bardo et al 1996; Laviola and Adriani 1998), data from Experiment 1 indicated that, following the opening of a partition, all subjects showed a novelty-induced arousal as well as a clear-cut preference for the novel environment. Important carry-over effects of the manipulation of weaning time were found, in that the profile exhibited by Wean-15 mice consisted of a quick attraction for the novel environment, which was followed by a monotonic habituation trend.…”

Section: Novelty Seeking and Novelty-induced Arousalsupporting

confidence: 89%

“…In fact, Wean-27 mice spent overall more time in the novel environment than the regular-weaning control group. Hence, a delay in weaning age resulted in adult individuals exhibiting a longer exploration of the novel environment.It has been reported that levels of locomotion expressed during the exploration of the novel compartment are lower than those exhibited in the familiar one; that is, a slight behavioral inhibition is usually associated with a novel environment (Misslin and Ropartz 1981;Bardo et al 1996;Laviola and Adriani 1998). Indeed, during exploration of a novel environment, mice are reported to express both approach (sniffing and smelling) and avoidance (stretched attend, stretched advance) reactions.…”

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confidence: 99%

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Spontaneous Novelty Seeking and Amphetamine-induced Conditioning and Sensitization in Adult Mice Evidence of Dissociation as a Function of Age at Weaning

Adriani

Laviola

2002

Neuropsychopharmacology

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Individual differences in coping with novelty and in the response to psychoactive drugs have been related to early life events, such as the age of weaning. Outbred CD-1 mice underwent a precocious (postnatal day (pnd) Apart from the individual genetic background, individual differences in the seeking for novelty and in vulnerability to drug abuse may also be the consequence of critical experiences occurring early in life. There is indeed a growing literature investigating the effects of precocious manipulations upon brain and behavioral regulations in animal models (for a review, see Laviola and Terranova 1998). In this context, the gradual transition to nutritional and behavioral independence, which NO . 2 takes place at weaning, can well be seen as a centerpiece in development. This is a period of neural and behavioral organization, and hence a potential vulnerability of CNS structures can be hypothesized (Greenough et al. 1990). Moreover, whereas the date of weaning is fixed in most rodent studies around the end of the third postnatal week, weaning is a gradual phenomenon under natural conditions (Galef 1981). Individual differences in the process of separation from the mother might lead to hormonal and behavioral consequences that contribute to the natural variability of phenotypes (Cirulli et al. 1997).Experimental manipulation of weaning time in cats and rats has been shown to affect a wide range of facets of the adult behavioral repertoire: specifically, it has been suggested that pups may adaptively respond to precocious weaning by speeding up subsequent development (Bateson et al. 1990). Accordingly, when compared with a regular weaning group, animals weaned precociously show a number of behavioral (Martin and Bateson 1985;Terranova and Laviola 1995;Loggi et al. 1996;Terranova et al. 2000) and neurochemical (see e.g. Sharman et al. 1982;Mann and Sharman 1983) changes, which can be regarded as signs of advanced ontogeny. Conversely, it has been shown that weaning itself acts as a developmental stimulus for the expression and onset of functional control of a specific opioid receptor (delta subpopulation), and that a late weaning may delay such development (Muhammad and Kitchen 1993;Kitchen et al. 1994; see also Terranova and Laviola 2001). Dopaminergic CNS systems have been reported to undergo maturation during the pre-and post-weaning period (Rao et al. 1991;Teicher et al. 1995;Moll et al. 2000). The individual organization of this neurobehavioral system might hence be affected by an early or a delayed separation from the lactating dam. Indeed, age at weaning is reported to affect the development of the dopaminergic system as well as the response to dopaminergic drugs (Cirulli et al. 1997;Laviola & Dell'Omo 1997).It has been recently suggested that the activation of brain mesolimbic pathways, which are involved in reward-related phenomena and motivation (Robbins and Everitt 1996;Wise 1996), share a common neurobiological substrate with the active search of novelty and other natural rewarding sensati...

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Section: Novelty Seeking and Novelty-induced Arousalsupporting

confidence: 89%

mentioning

confidence: 99%

Spontaneous Novelty Seeking and Amphetamine-induced Conditioning and Sensitization in Adult Mice Evidence of Dissociation as a Function of Age at Weaning

Adriani

Laviola

2002

Neuropsychopharmacology

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“…In the novelty-seeking test, exploratory activity and emotional reactivity represent two different dimensions based on different mechanisms (Zimmermann et al 2001). A profile of hyperlocomotion during exploration of novel environments has been proposed as an index of novelty-induced stress (Exner and Clark 1993;Misslin and Ropartz 1981;Misslin et al 1982). Present data may suggest that prenatal treatment with BPA produced rats that were more likely to experience noveltyinduced stress during adolescence or, alternatively, a slowing down of the process of habituation.…”

Section: Discussionmentioning

confidence: 87%

“…The latter is indeed characterized by the onset of prominent hormonal regulation. For this reason, BPA-exposed rats of both sexes were assessed in a novelty preference test (Bardo et al 1988;Misslin and Ropartz 1981) during adolescence (Spear and Brake 1983).…”

mentioning

confidence: 99%

Altered profiles of spontaneous novelty seeking, impulsive behavior, and response to D-amphetamine in rats perinatally exposed to bisphenol A.

Adriani

Seta²,

Dessì‐Fulgheri³

et al. 2003

Environ Health Perspect

107

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Bisphenol A (BPA) is an environmental estrogen with potentially averse effects on public health. We studied the long-term effects of perinatal exposure to BPA on later behavior in adult rats of both sexes. BPA or vehicle was administered orally to mother rats from mating to pups' weaning, at a concentration (0.040 mg/kg) within the range of human exposure. The offspring of both sexes were tested at adolescence (postnatal days 35-45) for novelty preference (experiment 1). After a 3-day familiarization to one side of a two-chamber apparatus, on day 4 rats were allowed to freely explore the whole apparatus. BPA-exposed females spent significantly less time than did controls in exploration of the novel side (i.e., increased neophobia), whereas no effect was found in the male group. At adulthood, the same animals were food deprived and tested for profiles of impulsive behavior (experiment 2), in operant chambers provided with two nose-poking holes (delivering either five or one food pellet). After the establishment of a baseline preference for the large reinforcer, a delay was introduced before the delivery of the five food pellets, which was progressively increased each day (10, 20, 30, 45, 60, 80, 100 sec). As expected, all animals exhibited a progressive shift toward the immediate but smaller reinforcer. A reduced level of impulsive behavior (i.e., a shift to the right in the intolerance-delay curve) was evidenced in BPA-treated rats. The frequency of inadequate responding (during the length of the delay) also provided a measure of restless behavior. Interestingly, the profile of BPA-treated males was feminized, strongly resembling that of control females. Animals were then tested (experiment 3) for the response to an amphetamine challenge (1 mg/kg, subcutaneously). The drug-induced increment activity was significantly less marked in BPA-treated male rats compared with controls. These findings provide clear indirect evidence of long-term alterations in brain monoaminergic function after perinatal BPA exposure. This may be a cause for concern for public health, confirming that exposure to a weak environmental estrogen in the period of sexual differentiation of the brain can influence adult behavior.

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“…Amphetamine reduces exploration of novel environments in situations lacking programmed reinforcement (Hughes and Greig, 1976;Kumar, 1969Kumar, , 1971Misslin and Ropartz, 1981;Robbins and Iversen, 1973). In such situations, exploration does not interfere with goal-directed behavior and cannot be considered equivalent to distraction.…”

Section: Introductionmentioning

confidence: 97%

A rat model of distractibility: effects of drugs modifying dopaminergic, noradrenergic and GABA ergic neurotransmission

Ågmo

Belzung

Rodríguez

1997

J. Neural Transmission

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A procedure for analyzing effects of drugs on distractibility is proposed. Rats are trained to traverse a straight runway with a sucrose solution as reinforcement. Once the response has been acquired, an additional runway ending in an empty box is connected. The time spent investigating this additional runway is the measure of distractibility. Amphetamine, 1 mg/kg i.p., increased distractibility. In rats that were never reinforced, amphetamine at a dose of 1 mg/kg reduced the time spent in the additional runway. This shows that the effects of amphetamine in the reinforced animals cannot be interpreted as enhanced exploration. Furthermore, the benzodiazepines diazepam (2 and 4 mg/kg, i.p.) and chlordiazepoxide (2.5, 5 and 10 mg/kg, i.p.), known to enhance exploration of novel environments, did not affect the time spent in the additional runway in sucrose-reinforced animals. It was concluded that the procedure indeed is a model of distractibility. The dopamine antagonist cis(Z)-flupenthixol, at a dose of 0.25 mg/kg, i.p., blocked the effects of amphetamine, 1 mg/kg. Flupenthixol itself, in doses of 0.25 and 0.5 mg/kg, did not affect the time spent in the additional runway. This suggests that enhanced dopaminergic activity indeed is responsible for the effects. This proposal is further supported by experiments showing that the noradrenaline precursor dihydroxyphenylserine (10 mg/kg + carbidopa, 50 mg/kg, both i.p.) and the noradrenergic neurotoxin DSP4 (50 mg/kg, i.p.) had no effect on distractibility. Moreover, amfonelic acid, a dopamine releaser with slight or no effect on noradrenergic neurotransmission, had effects very similar to those of amphetamine when given in doses of 0.25 and 0.5 mg/kg, i.p. A lower dose, 0.125 mg/ kg, was ineffective. Taken together, these data suggest that enhanced dopaminergic neurotransmission increases distractibility in the rat. However, both amphetamine and amfonelic acid may stimulate serotonin release. Until serotonergic drugs have been tested, a contribution of this transmitter cannot be ruled out. The distraction procedure may constitute an animal model of some kinds of disordered information processing.

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Effects of methamphetamine on novelty-seeking behaviour by mice

Cited by 60 publications

References 21 publications

Spontaneous Novelty Seeking and Amphetamine-induced Conditioning and Sensitization in Adult Mice Evidence of Dissociation as a Function of Age at Weaning

Spontaneous Novelty Seeking and Amphetamine-induced Conditioning and Sensitization in Adult Mice Evidence of Dissociation as a Function of Age at Weaning

Altered profiles of spontaneous novelty seeking, impulsive behavior, and response to D-amphetamine in rats perinatally exposed to bisphenol A.

A rat model of distractibility: effects of drugs modifying dopaminergic, noradrenergic and GABA ergic neurotransmission

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