Effects of Methanol Extract of Gongronema latifolium Leaves on Glycaemic Responses to Carbohydrate Diets in Streptozotocin-induced Diabetic Rats

Sylve, M.C. Udeh; Nwodo, O. F. C.; Yakubu, O. E.; Parker, Elijah Joshua; Egba, S.; Anaduaka, E.; Tatah, Verwiyeh Silas; Ugwu, O.P.; Ale, E.M.; Ude, C.M.; Iornenge, T.J.

doi:10.3923/jbs.2022.70.79

Cited by 6 publications

(9 citation statements)

References 42 publications

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“…Epigenetic changes have also been shown to have differential effects on diabetes incidence depending on the population studied, and such changes might be very important in African populations given early-life risks of under nutrition [27,28]. Studies in sub-Saharan African populations suggest that natural selection has acted on several genomic regions associated with obesity and type 2 diabetes, and a study that mapped the genetic risk of type 2 diabetes by measuring the allelic frequency of 16 diabetesassociated variants in 51 populations suggested that Africans face the greatest known genetic risk for type 2 diabetes of any ethnicity studied thus far [29][30][31][32][33][34][35][36][37]. Globally, 83.3% of diabetic patients have type 2 diabetes mellitus while almost 98% of diabetic patients below 15years have type 1 diabetes mellitus [38][39][40][41][42][43][44][45].…”

Section: Discussionmentioning

confidence: 99%

“…These findings are in agreement with the report that was released by Ugandan ministry of health in 2014 that indicated that the onset of type 2 DM was in late 30s and the prevalence increased with age unlike type 1 DM that was dominate among those aged 15years ad below [33]. According to a study done by Kajoba Dickson, females were the most affected group (60%) for both type 2 and type 1 diabetes [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. Further analysis showed that diabetes type 2 was strongly affected by gender (p=0.035).…”

Section: Discussionmentioning

confidence: 99%

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Factors associated with Diabetes Mellitus among Patients Aged 18 to 60 years Attending Diabetic Clinic at Hoima Regional Referral Hospital-Hoima District

Ivan

2024

NIJRMS

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Diabetes mellitus often referred to simply as diabetes, is defined as a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin produced. Insulin is a hormone that is needed to convert or regulate sugar (glucose), starches, and other food into energy needed for daily life and if the body cells do not absorb the glucose, the glucose accumulates in the blood (hyperglycemia) causing severe adverse effects to many body systems including the nervous, digestive, circulatory, endocrine and urinary systems, but all body systems are in some way affected. Thus, diabetes is a metabolic and multi-system disorder. Type 2 results from the body’s ineffective use of insulin. It is common in middle-aged and later life, although it had been more frequently seen in adolescents and young adults due to an increase in child obesity and inactivity and comprises between 90% and 95% of people with diabetes around the world. This study aimed to determine the factors associated with diabetes mellitus among patients aged between 18 to 60 years attending diabetic clinics at Hoima Regional Referral Hospital. A cross-sectional study embracing both analytical and descriptive data was conducted whereby both qualitative and quantitative data were acquired using participant self-administered questionnaires and investigator-administered questionnaires using the convenience sampling technique. A total of 105 participants were studied, with a response rate of 97.1%. Results are depicted in 95% Confidence Intervals (C.I), Odd Ratios (OR), and P-values; all calculated using Binary Logistic Regression with Pearson’s correlation in the Statistical Package for Social Sciences (SPSS) Version 20. Graphical representation was done by Microsoft Excel Software. A total of 105 participants was studied, with a response rate 97.1%. The results based on the 102 respondents showed that about 62(60.6%) of the respondents were female and 38(39.4%) were male. The mean age of the study population was 35 years with a standard deviation of 6.32 years. The significance of the associated factors was computed using Pearson’s correlation with the female gender being significant at P=0.021; increasing age being significant with a value of P=0.002; family history of diabetes being significant at P=0.027* with a 2-tailed test at 95% confidence level, P<0.05. The study showed that diabetes mellitus was highly associated with a positive family history of diabetes, the female gender, and social life. Keywords: Diabetes mellitus, Insulin, Glucose, Female gender, Body systems

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Factors associated with Diabetes Mellitus among Patients Aged 18 to 60 years Attending Diabetic Clinic at Hoima Regional Referral Hospital-Hoima District

Ivan

2024

NIJRMS

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“…This could be attributed with the level of satisfaction and comfort achieved when a woman owns her residential house and vice visa. However other studies have reported a higher likelihood of home renting to overweight and obesity [37][38][39][40][41][42][43][44].…”

Section: Socio-economic Factors Associated Overweight and Obesity Amo...mentioning

confidence: 99%

Assessment of Overweight, Obesity and Lifestyle-Related Factors Among Women Aged 18-49 Years in Kizinda, Bushenyi District

Hadson

2024

INOSR AS

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The trend of overweight and obesity was growing with shifts in individual and behavioral factors. Globally, overweight and obesity becoming a major problem, yet extensive data especially in Africa is still lacking. The objectives of the study were to determine the prevalence, socio-economic, and lifestyle-related factors associated with overweight and obesity among women aged 18-49 years in Kizinda in Bushenyi district. A cross-sectional analytical study design was used. Data on prevalence was collected through anthropometric measurements using the BMI (Body Mass Index) while those of socio-economic and individual factors were collected with a structured questionnaire. 271 women aged 18-49 years in Kizinda Trading Center, Bushenyi district were sampled. The prevalence of overweight and obesity among women of reproductive age in Bushenyi town was 47.24% and 19.92% respectively. Housewives were twice as likely to be overweighed and obese [AOR: 2.10, 95% CI (0.87- 3.15)]. Unemployed women have 74% [AOR: 1.26, 95% CI (0.50-2.36)] higher odds of being overweight or obese and those who earn >700000 shillings have 37% [AOR: 1.63, 95% CI (0.56-2.25)] higher odds to be overweight and obese. Compared with women who live in rented houses, those who live in their own houses were 48% [AOR: 1.52, 95% CI (0.78-2.94)] higher odds of being overweight or obese. Women who engaged in physical activity had 65% [AOR: 0.35, 95% CI (0.17-1.27)] less odds of being overweight or obese compared to those who did not. Participants whose food intake is mostly rice and ghee had 55% [AOR: 1.45, 95% CI (0.40-1.27)] and 44% [AOR: 1.56, 95% CI (0.53-2.11)] more odds of being overweight or obese respectively compared to those who take Posho. Women whose food intake was mostly milk were two times [AOR: 2.01, 95% CI (0.55-2.75)] more likely to be overweighed or obese compared to those who take Posho. The high prevalence of overweight and obesity among women of reproductive age in Bushenyi calls for serious attention. Public health interventions through awareness programs about the consequences of overall and abdominal obesity should be implemented. Keywords: Overweight, Obesity, Posho, Women, Housewives.

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“…The aim of this review is to bridge this knowledge gap by undertaking a comprehensive examination of the medicinal plants utilized in managing Diabetes Mellitus within Uganda [20][21][22][23]. Through this investigation, the intent is to shed light on their effectiveness, safety profiles, and underlying mechanisms, providing a deeper understanding of their potential role in diabetes management.…”

Section: Introductionmentioning

confidence: 99%

Exploring Indigenous Medicinal Plants for Managing Diabetes Mellitus in Uganda: Ethnobotanical Insights, Pharmacotherapeutic Strategies, and National Development Alignment

Paul-Chima,

Erisa,

Raphael

et al. 2023

INOSR ES

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Diabetes Mellitus (DM) stands as a pressing global health concern, particularly in Uganda, where its prevalence mirrors global trends driven by urbanization, lifestyle changes, and genetic predispositions. This study delves into Uganda's rich heritage of medicinal plants, investigating their use in managing DM within local communities. A comprehensive review was conducted, exploring the epidemiology and pathophysiology of DM in Uganda, emphasizing genetic predispositions, lifestyle factors, and the healthcare landscape. The study unveils indigenous medicinal plants employed for DM management, detailing their usage, preparation, and potential therapeutic properties. Additionally, the pharmacotherapeutic landscape for DM management, encompassing oral hypoglycemic agents, injectable therapies, and adjunctive medications, is scrutinized in alignment with Uganda's healthcare policies. Moreover, the study aligns strategies for DM management with Uganda's National Development Plan (NDP), outlining an integrative approach for healthcare infrastructure, primary care strengthening, sustainable financing, health information systems, and collaborative partnerships. Keywords: Diabetes Mellitus, Medicinal Plants, Uganda, Ethnobotany, Pharmacological Evaluation, National Development Plan, Integrated Healthcare Strategies

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Effects of Methanol Extract of Gongronema latifolium Leaves on Glycaemic Responses to Carbohydrate Diets in Streptozotocin-induced Diabetic Rats

Cited by 6 publications

References 42 publications

Factors associated with Diabetes Mellitus among Patients Aged 18 to 60 years Attending Diabetic Clinic at Hoima Regional Referral Hospital-Hoima District

Factors associated with Diabetes Mellitus among Patients Aged 18 to 60 years Attending Diabetic Clinic at Hoima Regional Referral Hospital-Hoima District

Assessment of Overweight, Obesity and Lifestyle-Related Factors Among Women Aged 18-49 Years in Kizinda, Bushenyi District

Exploring Indigenous Medicinal Plants for Managing Diabetes Mellitus in Uganda: Ethnobotanical Insights, Pharmacotherapeutic Strategies, and National Development Alignment

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