Effects of methanol extractsof insulin leaves (Tithonia diversifolia (hemsl.) A. Gray) on insulin resistance and secretion of alloxan induced-obese diabetic rats

Fitriyanto, Raden Edi; Sugiarto, Sugiarto; Ardiyanto, Dwi Tonang

doi:10.20885/jkki.vol11.iss2.art11

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…10 Tithonia diversifolia was demonstrated to reduce the blood sugar levels of diabetic rats. 11,12 In a previous study, TDL extract at doses of 25 mg/kg BW, 50 mg/kg BW, and 100 mg/kg BW significantly reduce blood sugar levels.12 However, in this study, with a similar treatment, TDL extract administration at a 25 mg/kg BW dose was insufficient to increase the NO level, as shown in Table 1. Meanwhile, K.4 and K.5 groups demonstrated an increase in NO levels compared to the diabetic control group.…”

Section: Discussionmentioning

confidence: 51%

The effect of Tithonia diversifolia extract against the level of nitric oxide in streptozotocin-nicotinamide-induced rats model

Sati,

Rahmadianto,

Kuncoro

et al. 2022

JKKI

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Background: One indication of microvascular dysfunction in diabetes mellitus (DM) is decreased nitric oxide (NO) levels. Tithonia diversifolia leaves (TDL) extract has been scientifically demonstrated to decrease glucose levels in diabetic rats.Objective: This study aims to examine the effect of TDL extract on NO levels in diabetic rats.Methods: True experimental with pre-post test control group design used 25 Sprague-Dawley rats. Its were divided into 5 groups: healthy control (K.1); diabetic control (K.2); diabetes rats with ethanol extract of TDL at a dose of 25 (K.3); 50 (K.4); and 100 mg/kg BW (K.5) for 28 days. We use a combination of nicotinamide (230 mg/kg BW) and streptozotocin (65 mg/kg BW) to induce diabetes mellitus. The blood serum was taken before and after extract administration. NO level was assessed using spectrophotometry. Paired T-test, Wilcoxon, one-way ANOVA, and post hoc LSD were performed for statistical analysis.Results: There were significant differences in NO levels before and after treatment in all groups unless K.5 (100 mg/kg BW). Furthermore, there was no significant difference in NO levels in the healthy control and the K.5 group but significant differences in other groups.Conclusion: TDL extract can prevent the decrease in NO level in diabetic rats model with the effective dose of 100 mg/kg BW.

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Section: Discussionmentioning

confidence: 51%

The effect of Tithonia diversifolia extract against the level of nitric oxide in streptozotocin-nicotinamide-induced rats model

Sati,

Rahmadianto,

Kuncoro

et al. 2022

JKKI

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“…The assessment of insulin resistance was based on the FBG levels and insulin levels. Assessment of insulin resistance used a simple method using the HOMA-IR calculation formula (Fitriyanto et al 2020).…”

Section: Methodsmentioning

confidence: 99%

The Effect of Combined Extracts of Sappan Wood (Caesalpinia sappan L.) and Gotu Kola (Centella asiatica L.) in Improving Diabetic Condition in Rats

Putri¹,

Wasita²,

Febrinasari³

2022

Jgizipangan

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This study aimed to determine the efficacy of combination of sappan (secang) wood and gotu kola extracts in reducing insulin resistance and Malondialdehyde (MDA) levels in diabetic rats induced by Streptozotocin (STZ) 65 mg/kg Body Weight (BW) and Nicotinamide (NA) 230 mg/kg BW. Forty-two male Sprague Dawley rats weighing ±200 g were divided into 7 groups: 1) control, 2) glibenclamide 0.45 mg/kg BW, 3) sappan wood extract (CS) 250 mg/kg BW, 4) gotu kola extract (CA) 500 mg/kg BW, 5) 1 st combination of extracts of sappan wood and gotu kola (CSCA1) 125 mg/kg BW + 750 mg/kg BW, 6) 2 nd combination (CSCA2) with 250 mg/kg BW + 500 mg/kg BW, and 7) 3 rd combination (CSCA3) with 375 mg/kg BW + 250 mg/kg BW. The insulin resistance levels were measured using the HOMA-IR index based on fasting blood glucose and insulin. The Thiobarbituric Acid Reactive Substance (TBARs) method was used to measure MDA levels. All measurements were taken before treatment, 14 days after treatment, and 21 days after treatment. The group receiving CSCA3 showed significant reduction in insulin resistance (-3.32±0.05) and MDA levels (-2.04±0.37 nmol/ml) on Day 21 after treatment. The CSCA3 treatment did not show statistically different result compared to glibenclamide treatment (p>0.05). Hence, CSCA3 treatment was considered as the best proportion of sappan wood and gotu kola extracts mixture and the result is comparable to glibenclamide. This study shows that the combination of sappan wood and gotu kola extracts has the potential to be developed as a functional drink for people with diabetes.

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“…9 The tissue's sensitivity to insulin will decrease as a result of this condition, and the pancreas' beta cells will instantly compensate by boosting insulin synthesis, resulting hyperinsulinemia. 10 By complex processes, hyperinsulinemia increases androgen production. 11,12 The age of menarche is another factor that may influence the occurrence of PCOS.…”

Section: Introductionmentioning

confidence: 99%

Family history of PCOS, obesity, low fiber diet, and low physical activity increase the risk of PCOS

Wahyuni,

Supriyatiningsih,

Kusumawati

et al. 2022

JKKI

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Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder and leading cause of prolonged anovulation. PCOS has been linked to a variety of long-term health problems, including: heart disease; metabolic syndrome; and diabetes. It is interesting to know the risk factors for PCOS in local settings.Objective: The aim of this research is to identify PCOS risk factors in our own settings (Asri Medical Center in Yogyakarta), so that we could identify the specific preparation to avoid having disorders personalized in localcharacteristics.Methods: This is a descriptive-analytic cross-sectional study. The research was carried out at Asri Medical Center in Yogyakarta, Indonesia, with a total sample size of 92 people who met the inclusion and exclusion criteria. They were divided into two groups: non-PCOS and PCOS. Data were retrieved using the questionnaire. The variables evaluated were nutritional status, physical activity, carbohydrate diet, fiber diet, family history of diabetes, family history of PCOS, and age of menarche. The data was analyzed usingthe Chi-square test.Results: Family history of PCOS, obesity, low physical activity and a lowfiber diet proved to differ significantly between the two groups (p<0.05).Conclusion: Family history of PCOS, obesity, low physical activity, low fiber diet had a substantial impact on the occurrence of PCOS.

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Effects of methanol extractsof insulin leaves (Tithonia diversifolia (hemsl.) A. Gray) on insulin resistance and secretion of alloxan induced-obese diabetic rats

Abstract: ARTICLE INFOEffects of methanol extracts of insulin leaves (Tithonia diversifolia (hemsl.) A. Gray) on insulin resistance and secretion of alloxan induced-obese diabetic rats

Cited by 3 publications

References 29 publications

The effect of Tithonia diversifolia extract against the level of nitric oxide in streptozotocin-nicotinamide-induced rats model

The effect of Tithonia diversifolia extract against the level of nitric oxide in streptozotocin-nicotinamide-induced rats model

The Effect of Combined Extracts of Sappan Wood (Caesalpinia sappan L.) and Gotu Kola (Centella asiatica L.) in Improving Diabetic Condition in Rats

Family history of PCOS, obesity, low fiber diet, and low physical activity increase the risk of PCOS

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