2023
DOI: 10.13181/mji.oa.236944
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Effects of methotrexate, <em>Moringa oleifera</em>, and <em>Andrographis paniculata</em> extracts on the myocardial and aortic tissue of streptozotocin-nicotinamide-induced hyperglycemic rats

Dimas Bathoro Bagus Pamungkas,
Viskasari Pintoko Kalanjati,
Abdurachman
et al.

Abstract: BACKGROUND Methotrexate (MTX) could lower glucose levels in type 1 diabetes mellitus, while Moringa oleifera and Andrographis paniculata supplementations have similar effects on hyperglycemia. This study aimed to analyze the effects of MTX, M. oleifera, and A. paniculata leaf extracts on the myocardial interleukin (IL)-6 and the histopathology of the left ventricle and aorta. METHODS 49 rats were divided equally into 7 groups: negative control and diabetic induced by streptozotocin-nicotinamide (STZ-NA) … Show more

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