Effects of methsuximide and mephenytoin on the behavior of pigeons under a repeated acquisition procedure

Delaney, Dawn; Poling, Alan

doi:10.1016/0091-3057(87)90510-7

Cited by 11 publications

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“…The former drug is a succinimide, the latter a hydantoin; therefore, comparing their effects to those previously reported for ethoso_ximide (a succinimide) and phenytoin (a hydantoin) is of interest. Previous investigations reveal that the effects of mephenytoin and phenytoin are similar in pigeons responding under a repeated acquisition procedure, whereas those of ethosuximide and methsuximide differ (Picker and Poling 1984;Delaney and Poling 1987). Under this assay, mephenytoin, phenytoin, and methsuximide substantially increased errors (impaired learning), but ethosuximide failed to do so.…”

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confidence: 92%

Effects of methsuximide and mephenytoin on the responding of pigeons under a fixed-consecutive-number schedule with and without an external discriminative stimulus

1988

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The effects of the antiepilepsy drugs methsuximide and mephenytoin were examined in pigeons responding under a fixed-consecutive-number (FCN) schedule with and without an added external discriminative stimulus. On this schedule, food was delivered whenever subjects responded between 8 and 12 times on one response key (work key), and then responded once on a second response key (reinforcement key). Under one variant of the FCN schedule (FCN 8-SD), an external discriminative stimulus signalled completion of the response requirement on the work key; no such stimulus change occurred under the other (FCN 8) schedule. The two FCN schedules (with an without stimulus change) alternated at 5-min intervals within each session for all subjects. Methsuximide (25-200 mg/kg) and mephenytoin (40-160 mg/kg) produced generally dose-dependent decreases in percentage of reinforced response runs and rate of responding. The magnitudes of these effects were comparable under both variants of the FCN schedule.

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confidence: 92%