Effects of Methyl Parathion on Reproduction in the Japanese Quail

Solecki, Roland; Faqi, Ali S.; Pfeil, R.; Hilbig, V.

doi:10.1007/s001289900275

Cited by 12 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results lead to the conclusion that developing fish are more sensitive to low concentrations of MeP than their mothers. Analogous results have been reported in other vertebrates by Solecki et al (1996) who showed that birds fed MeP-spiked food laid fewer and lighter eggs than controls. Whereas Abu-Qare et al (2001) reported that AChE activity in fetal brains is more sensitive to MeP than maternal AChE activity.…”

Section: Discussionsupporting

confidence: 87%

Effects of methyl parathion exposure on development and reproduction in the viviparous fish Girardinichthys multiradiatus

Arellano-Aguilar

Garcı́a

2008

Environmental Toxicology

View full text Add to dashboard Cite

Methyl parathion (MeP), an insecticide commonly used in Mexico, has been detected in water bodies adjacent to agricultural crops and is accumulated in the tissue of the amarillo (Girardinichthys multiradiatus), a viviparous fish unique to Central Mexico. Evidence of MeP accumulation in a G. multiradiatus population prompted assessment of the consequences of exposure to MeP during the gestation period and adult life. We exposed adult fish to MeP in the diet at concentrations ranging from 0.001 to 0.165 microg/g dry weight of food. Fish accumulated MeP at concentrations from 0.21 to 5.87 microg/g of fish and exhibited a significant reduction in weight and growth rate. We also evaluated the effects on broods of pregnant females exposed to 0.005, 0.01, and 0.1 microg/g dry weight of food. Although these pregnant females were not affected, their offspring showed an increase in spinal cord malformation and a reduction in survival to adulthood. Finally, we sampled seven localities inhabited by G. multiradiatus; this revealed the presence of MeP in two water bodies at concentrations of 0.0036 and 0.037 microg/mL respectively. Our results suggest that low MeP concentrations affect immature fish with possible consequences later in life.

show abstract

Section: Discussionsupporting

confidence: 87%

Effects of methyl parathion exposure on development and reproduction in the viviparous fish Girardinichthys multiradiatus

Arellano-Aguilar

Garcı́a

2008

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

“…exposures to MP, rather than exposures for 5 days or 12 days, decreased the body weight ( Fig. 1 a and b) in consensus with the earlier reports (IPCS, 1993;Solecki et al, 1996), and that effect was due to diminished food and water intake in treated rats of experiments 4 and 5 (Solecki et al, 1996). Decrease in testis weight only in rats belonging to experiments 4 and 5 revealed the fact that sufficient gonadotoxicity could be seen only after prolonged exposure to MP, regardless of routes of exposure (Table 1).…”

Section: Body Weight and Testis Weightsupporting

confidence: 92%

An Organophosphate Insecticide Methyl Parathion (O- O- Dimethyl O-4-Nitrophenyl Phosphorothioate) Induces Cytotoxic Damage and Tubular Atrophy in the Testis Despite Elevated Testosterone Level in the Rat

Narayana

Prashanthi²,

Arunkumar³

et al. 2006

J. Toxicol. Sci.

View full text Add to dashboard Cite

-Methyl parathion (MP) is an organophosphate pesticide used in agriculture, although quite often illegally used indoors to contain insects. The present study was planned to investigate the effects of MP on rat testis. Adult male Wistar rats (13-14 weeks) were treated with MP as follows. Experiment 1-0, 1.75, 3.5 or 7 mg/kg i.p. for 5 days and sacrificed on Day 14; experiment 2 and 3-0, 0.5, or 1 mg/kg i.p. for 12 days, and sacrificed on Days 130 and 77, respectively; experiment 4-0, 0.75, or 1.5 mg/kg i.p. for 25 days, and sacrificed on Day 17; experiment 5-0 or 3.5 mg/kg po for 25 days, and sacrificed on Day 17, after the last exposure. MP decreased the body weight and the testis weight in experiments 4 and 5 (p<0.05-0.001) due to decreased food intake and tubular atrophy respectively. MP increased the intra-testicular testosterone level and decreased the LH level in experiments 4 and 5. The seminiferous epithelium showed sloughing of germ cells, vacuoles, focal necrosis, and formation of multinucleated giant cells, cellular degeneration (nuclear pyknosis, halo appearance and shrinkage of nuclei) and tubular atrophy, especially in experiment 4. The degree of testicular damage was higher in experiment 4>5>1>3>2 indicating more effect of prolonged i.p. treatment. Homogenization-resistant spermatid count was decreased in experiments 1, 4 and 5, and MP also decreased the tubular diameter, and epithelial height (p<0.05-0.001). Incidences of stage XIV tubules, number of meiotic figures and elongating spermatids were also decreased, whereas the incidence of tubules showing epithelial sloughing increased (p<0.05-0.001). We conclude that MP is a reproductive toxicant in male rats which causes significant testicular damage in the testis.

show abstract

“…Consistent with our finding, Budreau and Singh (1973) reported that organophosphate pesticides are embryotoxic and can induce fetal anomalies in experimental animals. Several studies have indicated that methyl parathion exposure has toxic effects to mammals, fishes, birds, and non-target invertebrates (Solecki et al 1996; Fanta et al 2003; Roque et al, 2005). …”

Section: Discussionmentioning

confidence: 99%

Involvement of oxidative stress in methyl parathion and parathion‐induced toxicity and genotoxicity to human liver carcinoma (HepG₂) cells

Edwards

Yedjou

Tchounwou

2011

Environmental Toxicology

View full text Add to dashboard Cite

Methyl parathion (C8H10NO5PS) and parathion (C10H14NO5PS) are both organophosphate insecticides (OPI) widely used for household and agricultural applications. They are known for their ability to irreversibly inhibit acetylcholinesterase which often leads to a profound effect on the nervous system of exposed organisms. Many recently published studies have indicated that human exposure to OPI may be associated with neurologic, hematopoietic, cardiovascular, and reproductive adverse effects. Studies have also linked OPI exposure to a number of degenerative diseases including Parkinson's, Alzheimer's, and amyotrophic lateral sclerosis. Also, oxidative stress (OS) has been reported as a possible mechanism of OPI toxicity in humans. Hence, the aim of the present investigation was to use human liver carcinoma (HepG2) cells as a test model to evaluate the role of OS in methyl parathion- and parathion-induced toxicity. To achieve this goal, we performed the MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] assay for cell viability, lipid peroxidation assay for malondialdehyde (MDA) production, and Comet assay for DNA damage, respectively. Results from MTT assay indicated that methyl parathion and parathion gradually reduce the viability of HepG2 cells in a dose-dependent manner, showing 48 h-LD50 values of 26.20 mM and 23.58 mM, respectively. Lipid peroxidation assay resulted in a significant increase (p<0.05) of MDA level in methyl parathion- and parathion-treated HepG2 cells compared to controls, suggesting that OS plays a key role in OPI-induced toxicity. Comet assay indicated a significant increase in genotoxicity at higher concentrations of OPI exposure. Overall, we found that methyl-parathion is slightly less toxic than parathion to HepG2 cells. The cytotoxic effect of these OPI was found to be associated, at least in part, with oxidative cell/tissue damage.

show abstract

Effects of Methyl Parathion on Reproduction in the Japanese Quail

Cited by 12 publications

References 15 publications

Effects of methyl parathion exposure on development and reproduction in the viviparous fish Girardinichthys multiradiatus

Effects of methyl parathion exposure on development and reproduction in the viviparous fish Girardinichthys multiradiatus

An Organophosphate Insecticide Methyl Parathion (O- O- Dimethyl O-4-Nitrophenyl Phosphorothioate) Induces Cytotoxic Damage and Tubular Atrophy in the Testis Despite Elevated Testosterone Level in the Rat

Involvement of oxidative stress in methyl parathion and parathion‐induced toxicity and genotoxicity to human liver carcinoma (HepG₂) cells

Contact Info

Product

Resources

About

Effects of Methyl Parathion on Reproduction in the Japanese Quail

Cited by 12 publications

References 15 publications

Effects of methyl parathion exposure on development and reproduction in the viviparous fish Girardinichthys multiradiatus

Effects of methyl parathion exposure on development and reproduction in the viviparous fish Girardinichthys multiradiatus

An Organophosphate Insecticide Methyl Parathion (O- O- Dimethyl O-4-Nitrophenyl Phosphorothioate) Induces Cytotoxic Damage and Tubular Atrophy in the Testis Despite Elevated Testosterone Level in the Rat

Involvement of oxidative stress in methyl parathion and parathion‐induced toxicity and genotoxicity to human liver carcinoma (HepG2) cells

Contact Info

Product

Resources

About

Involvement of oxidative stress in methyl parathion and parathion‐induced toxicity and genotoxicity to human liver carcinoma (HepG₂) cells