Effects of Methyl Sulfonyl Methane and Selenium Yeast on Fatty Liver Syndrome in Laying Hens and Their Biological Mechanisms

Abstract

The purpose of this study was to explore the effects of MSM and Se-Y on FLS in laying hens during the late peak laying period and the underlying biological mechanisms. Therefore 240 55-week-old Jing-fen No. 6 laying hens were randomly divided into five groups, with eight replicates in each group and six laying hens in each replicate. The hens were fed a basal diet (Control) and diets supplemented with 350 and 700 mg/kg MSM and 25 and 50 mg/kg Se-Y, respectively, for four weeks. The results showed that MSM and Se-Y had no significant effects on the performance of laying hens. With the increasing dosage of MSM and Se-Y, the symptoms of liver steatosis in laying hens were reduced, and MSM and Se-Y could significantly reduce the content of malondialdehyde (MDA) in serum and liver (p < 0.05) and increase the contents of total superoxide dismutase (T-SOD) and glutathione peroxidase (GPX) in serum and liver (p < 0.05). The RNA-seq results showed that 700 mg/kg MSM significantly downregulated the expression levels of the ATP5I, ATP5G1, CYCS, and UQCRQ genes in the liver, and 50 mg/kg Se-Y significantly downregulated the expression levels of MAPK10, SRC, BMP2, and FGF9 genes in the liver. In conclusion, dietary supplementation with MSM and Se-Y can effectively reduce the FLS of laying hens in the late peak laying period and increase their antioxidant capacity. The underlying biological mechanism may be related to the downregulation of genes involved in liver oxidative phosphorylation and inflammation-related pathways.

Responses of intestinal morphology, immunity, antioxidant status and cecal microbiota to the mixture of glycerol monolaurate and cinnamaldehyde in laying hens

“…It is well known that MDA is a secondary lipid oxidation product and is considered to be the main product in evaluating lipid peroxidation ( Botsoglou et al, 2012 ). The activities of CAT, T-SOD and GPH-Px reflects the antioxidant status of the body ( Wang et al, 2023 ). In the current study, GCM supplemented with 500 mg/kg or 1,000 mg/kg showed a significant increment in the activities of hepatic and jejunal T-SOD and jejunal GSH-Px and a decrease in content of hepatic H 2 O 2 and jejunal MDA, which was consistent with the results of Zhao et al (2019) and Li et al (2022b) .…”

Positive effects of rutin on egg quality, lipid peroxidation and metabolism in post-peak laying hens

“…Liver stress during aging can worsen lipid metabolism disorders, and raise the likelihood of related metabolic diseases ( 6 ). Furthermore, in large-scale caged environments where laying hens have a limited mobility and reduced exercise, the excess unutilized energy is converted to fat and deposited in the abdomen and major metabolic organs ( 7 ). Consequently, how to mitigate some of the adverse effects of fat metabolism disorders on laying hens has become a pressing issue in large-scale egg production.…”