Effects of methylmercury exposure on glutathione metabolism, oxidative stress, and chromosomal damage in captive-reared common loon (Gavia immer) chicks

Kenow, Kevin P.; Hoffman, David J.; Hines, Randy K.; Meyer, Michael W.; Bickham, John W.; Matson, Cole W.; Stebbins, Katie R.; Montagna, Paul A.; Elfessi, Abdulaziz

doi:10.1016/j.envpol.2008.06.009

Cited by 40 publications

(23 citation statements)

References 28 publications

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“…Increased hepatic GSSG:GSH ratio was related to Hg in mallards, greater scaup, and double-crested cormorants. However, in two studies where birds were dosed with MeHg at various concentrations, hepatic GSH was not affected in common loons and increased only slightly in great egrets (Ardea alba) [34,35]. Pied flycatcher (Ficedula hypoleuca) nestlings exposed to lower Hg than the present study, in combination with other metals at contaminated field sites exhibited increased hepatic GSH [36].…”

Section: Hepatic Oxidative Stresscontrasting

confidence: 59%

Oxidative stress response of Forster's terns (Sterna forsteri) and Caspian terns (Hydroprogne caspia) to mercury and selenium bioaccumulation in liver, kidney, and brain

Hoffman

Eagles‐Smith

Ackerman

et al. 2011

Environmental Toxicology and Chemistry

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Bioindicators of oxidative stress were examined in prebreeding and breeding adult and chick Forster's terns (Sterna forsteri) and in prebreeding adult Caspian terns (Hydroprogne caspia) in San Francisco Bay, California. Highest total mercury (THg) concentrations (mean ± standard error; µg/g dry wt) in liver (17.7 ± 1.7), kidney (20.5 ± 1.9), and brain (3.0 ± 0.3) occurred in breeding adult Forster's terns. The THg concentrations in liver were significantly correlated with hepatic depletion of reduced glutathione (GSH), increased oxidized glutathione (GSSG):GSH ratio, and decreased hepatic gamma-glutamyl transferase (GGT) activity in adults of both tern species. Prefledging Forster's tern chicks with one-fourth the hepatic THg concentration of breeding adults exhibited effects similar to adults. Total mercury-related renal GSSG increased in adults and chicks. In brains of prebreeding adults, THg was correlated with a small increase in glucose-6-phosphate dehydrogenase (G-6-PDH) activity, suggestive of a compensatory response. Brain THg concentrations were highest in breeding adult Forster's terns and brain tissue exhibited increased lipid peroxidation as thiobarbituric acid-reactive substances, loss of protein bound thiols (PBSH), and decreased activity of antioxidant enzymes, GSSG reductase (GSSGrd), and G-6-PDH. In brains of Forster's tern chicks there was a decrease in total reduced thiols and PBSH. Multiple indicator responses also pointed to greater oxidative stress in breeding Forster's terns relative to prebreeding terns, attributable to the physiological stress of reproduction. Some biondicators also were related to age and species, including thiol concentrations. Enzymes GGT, G-6-PDH, and GSSGred activities were related to species. Our results indicate that THg concentrations induced oxidative stress in terns, and suggest that histopathological, immunological, and behavioral effects may occur in terns as reported in other species.

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Section: Hepatic Oxidative Stresscontrasting

confidence: 59%

Oxidative stress response of Forster's terns (Sterna forsteri) and Caspian terns (Hydroprogne caspia) to mercury and selenium bioaccumulation in liver, kidney, and brain

Hoffman

Eagles‐Smith

Ackerman

et al. 2011

Environmental Toxicology and Chemistry

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“…Neither adverse effects on growth or survival occurred in loons that were exposed to three doses, 0.1, 0.5, or 1.5 m g MeHg/g (wwt) (Kenow et al 2003 ) , nor behavioral effects at doses of 0.08, 0.4, or 1.2 m g MeHg/g (wwt) (Kenow et al 2010 ) . However, adverse effects on immune function (Kenow et al 2007a ) and effects related to oxidative stress and altered glutathione metabolism (Kenow et al 2008 ) occurred at 0.4 and 1.2 m g MeHg/g (wwt). Using a bm of 4.67 kg for common loon adults (Barr 1996 ;Dunning 1993 ) , a food intake rate of 0.839 kg/day was derived from the allometric equation for carnivorous birds (Nagy 2001 ) .…”

Section: Review Of Mehg Toxicity To Birdsmentioning

confidence: 99%

“…The effects of MeHg on growth (Kenow et al 2003 ) , behavior (Kenow et al 2010 ) , immune function (Kenow et al 2007a ) , and the biochemical index (Kenow et al 2008 ) of juvenile common loons were investigated during which individuals were exposed for 15 weeks. Neither adverse effects on growth or survival occurred in loons that were exposed to three doses, 0.1, 0.5, or 1.5 m g MeHg/g (wwt) (Kenow et al 2003 ) , nor behavioral effects at doses of 0.08, 0.4, or 1.2 m g MeHg/g (wwt) (Kenow et al 2010 ) .…”

Section: Review Of Mehg Toxicity To Birdsmentioning

confidence: 99%

Toxicity Reference Values and Tissue Residue Criteria for Protecting Avian Wildlife Exposed to Methylmercury in China

Zhang

et al. 2012

Reviews of Environmental Contamination and Toxicology

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“…The mechanisms producing the harmful effects of oxidative stress are complex with different biomolecular mechanisms associated with ecotoxicological and ecological aspects (Koivula & Eeva 2010). Components of the antioxidant defense system have the widest scope and greatest potential for use as subcellular biomarkers of the contamination of birds with metals from the environment (Berglund et al 2007(Berglund et al , 2011Hoffman 2002;Hoffman et al 2005Hoffman et al , 2009Hoffman et al , 2011Kamiński et al 2009a;Kurhalyuk et al 2006a, b;Kenow et al 2008;Koivula et al 2011;Martinez-Haro et al 2011;Mateo et al 2003;Mateo & Hoffman 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Antioxidants and their oxidation products are important indicators of oxidative stress induced by toxic chemicals from environment (Berglund et al 2007(Berglund et al , 2011Hoffman 2002;Hoffman et al 2005Hoffman et al , 2009Hoffman et al , 2011Kamiń-ski et al 2009a, b;Kurhalyuk et al 2006a, b;Kenow et al 2008;Koivula et al 2011;Martinez-Haro et al 2011;Mateo et al 2003;Mateo & Hoffman 2001).…”

Section: Introductionmentioning

confidence: 99%

Blood oxidative stress and antioxidant defense profile of White Stork Ciconia ciconia chicks reflect the degree of environmental pollution

Tkachenko¹,

Kurhaluk²

2014

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Abstract. Oxidative stress biomarkers in the blood of White Stork Ciconia ciconia chicks were analyzed during their development in nests in polluted and control environments. The control, relatively pure, environment was the village of Kłopot, with no industrial plants within a radius of 150 km. Blood samples were also collected in two polluted areas, including the suburban village of Czarnowo, located 20 km from the city of Zielona Góra (southwestern Poland) and an area near the town of Głogów, where a large Copper Manufacture is situated. We measured two markers of oxidative stress (2-thiobarbituric acid reactive substances (TBARS) and stable 2,4-dinitrophenyl hydrazine derivates of the oxidative modified carbonyl groups levels), as well as antioxidant defenses (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities, ceruloplasmin and total antioxidant capacity levels) in the blood samples. White Stork chicks from different environments are probably significantly susceptible to environmental conditions. In the unpolluted area, chicks showed lower lipid and protein oxidation levels, indicating that the variation in the pollution-induced oxidative stress among areas is dependent of environmental loads. Increased oxidative stress biomarkers can modify antioxidant defenses in chicks from various environments, principally causing increased glutathione peroxidase activity in chicks from polluted regions. Therefore, the use of oxidative stress biomarkers to assess the health and condition of chicks will be useful in future studies aiming to identify miscellaneous environmental loading.

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Effects of methylmercury exposure on glutathione metabolism, oxidative stress, and chromosomal damage in captive-reared common loon (Gavia immer) chicks

Cited by 40 publications

References 28 publications

Oxidative stress response of Forster's terns (Sterna forsteri) and Caspian terns (Hydroprogne caspia) to mercury and selenium bioaccumulation in liver, kidney, and brain

Oxidative stress response of Forster's terns (Sterna forsteri) and Caspian terns (Hydroprogne caspia) to mercury and selenium bioaccumulation in liver, kidney, and brain

Toxicity Reference Values and Tissue Residue Criteria for Protecting Avian Wildlife Exposed to Methylmercury in China

Blood oxidative stress and antioxidant defense profile of White Stork Ciconia ciconia chicks reflect the degree of environmental pollution

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