Effects of methylphenidate on body index and physical fitness in Korean children with attention deficit hyperactivity disorder

Kang, Kyoung Doo; Yun, Sin Weon; Chung, Un Sun; Kim, Tae Ho; Park, Jeong Ha; Park, In Hui; Han, Doug Hyun

doi:10.1002/hup.2514

Cited by 13 publications

(6 citation statements)

References 34 publications

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“…Nevertheless, literature is still inconsistent in the association between height growth and treatment with methylphenidate. Some studies report a significant delay in height among children treated with methylphenidate (Poulton and Cowell 2003;Swanson et al 2006Swanson et al , 2007Faraone et al 2008;Ptacek et al 2009;Zhang et al 2010;Poulton et al 2013Poulton et al , 2016Kim et al 2014;Powell et al 2015;Lentferink et al 2018), whereas some others do not observe any significant change in height between baseline and follow-up visits (Kramer et al 2000;Biederman et al 2003Biederman et al , 2010Harstad et al 2014;Kang et al 2016;Diez-Suarez et al 2017;McCarthy et al 2018).…”

Section: Effects Of Methylphenidate On Child Growth 191mentioning

confidence: 99%

The Effects of Methylphenidate Treatment on Child Growth in Thai Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

Koonrungsesomboon

2020

Journal of Child and Adolescent Psychopharmacology

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Objectives: To determine the effects of methylphenidate treatment on child growth in Thai pediatric patients with attentiondeficit/hyperactivity disorder (ADHD). Methods: The medical records of children and adolescents with ADHD, between 5 and 18 years of age, who received pharmacological treatment with methylphenidate as a sole psychiatric medication for ‡1 year between 2001 and 2018 at the Rajanagarindra Institute of Child Development, Thailand, were retrospectively reviewed. Data on anthropometric parameters and methylphenidate use were extracted. Height and weight were converted to age-and gender-corrected standard scores (z-scores) using norms from the Thai pediatric population. Changes in height and weight z-scores were assessed using a paired t-test or one-way repeated measures ANOVA with the Bonferroni correction. Results: In this retrospective observational study, 911 children and adolescents were eligible, with the mean age of 95.0 -19.5 months at baseline, the cumulative duration of methylphenidate treatment of 39.4 -23.5 months, and the average daily dosage of 14.1 -6.2 mg/day. Comparative analysis found no statistically significant change in height z-scores between baseline and last recorded measurement (mean difference = 0.0017, confidence interval [95% CI] = -0.0004 to 0.0038, p = 0.107), while a slight, but significant increase in weight z-scores was observed (mean difference = 0.0271, 95% CI = 0.0179-0.0362, p < 0.001). Longitudinal analysis observed that weight z-scores were significantly decreased during the first year of therapy, but regained in the second year and continued to increase in subsequent years of therapy. Conclusion: Treatment with methylphenidate in our cohort of Thai pediatric patients with ADHD was not associated with growth deficits, except for a slightly significant decrease in weight during the first year of therapy.

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Section: Effects Of Methylphenidate On Child Growth 191mentioning

confidence: 99%

The Effects of Methylphenidate Treatment on Child Growth in Thai Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

Koonrungsesomboon

2020

Journal of Child and Adolescent Psychopharmacology

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“…Previous studies have suggested that MPH may suppress growth in children with ADHD [2,3]. Other studies, on the contrary, have demonstrated that MPH treatment may not affect growth in children with ADHD [4,5]. It has also been suggested that the pathophysiology of ADHD itself could suppress growth [6].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Investigation of Association between Methylphenidate and Serum Growth Markers in Children with Attention-Deficit/Hyperactivity Disorder: A Cross-Sectional Case-Control Study

Kim

Bang

Kang

et al. 2020

J Korean Acad Child Adolesc Psychiatry

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It remains unclear whether methylphenidate (MPH) has yadverse effects on growth in children. This study aimed to investigate the association of MPH with serum biological markers of growth in children with attention-deficit/hyperactivity disorder (ADHD). Methods: The present study included 103 children with ADHD (64 drug-naive children, 39 MPH-treated children) and 112 control subjects. Children with ADHD were diagnosed on the basis of a semi-structured interview. Levels of biochemical markers of growth, including insulin-like growth factor-I, thyroid stimulating hormone (TSH), free T4, calcium, phosphorus, alkaline phosphatase, vitamin D, hemoglobin, total protein, albumin, total cholesterol, and hematocrit were measured in these individuals. Results: Except in case of TSH, no intergroup differences were found in the levels of the growth markers. The levels of TSH were found to be lower in the MPH-treated boys with ADHD than in the drug-naive and control groups (p<0.05), although the levels of TSH in all the groups were within normal limits. Conclusion: In this cross-sectional study, no significant association was found between MPH and growth markers. This calls for the need to carry out prospective longitudinal research studies in the future that investigate the effect of MPH on the growth trajectory in children.

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“…This clear need notwithstanding, the evaluation of stimulant safety in children with epilepsy faces several challenges. Clinical trials of stimulants for ADHD treatment, such as the major MTA study, have generally excluded children with epilepsy because of concern about possible risk of seizure exacerbation (MTA Group 1999a, b;Jadad et al 1999;Pearson et al 2013;Yatsuga et al 2014;Shang et al 2015;Slama et al 2015;Kang et al 2016;Ravi and Ickowicz 2016). Clinical trials or observational studies focusing on stimulant treatment for ADHD in children with epilepsy had common limitations of low baseline seizure rates, small sample size, and short observation periods (Torres et al 2008;Santos et al 2013;Ravi and Ickowicz 2016;Williams et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Stimulants Do Not Increase the Risk of Seizure-Related Hospitalizations in Children with Epilepsy

Carney

Bussing

Segal

et al. 2018

Journal of Child and Adolescent Psychopharmacology

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Effects of methylphenidate on body index and physical fitness in Korean children with attention deficit hyperactivity disorder

Abstract: Our findings support the effectiveness of MPH treatment for improving IQ, attention, and balance and agility measures of skill-related fitness in Korean children with ADHD. MPH was not associated with growth delays in height, weight, and BMI.

Cited by 13 publications

References 34 publications

The Effects of Methylphenidate Treatment on Child Growth in Thai Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

The Effects of Methylphenidate Treatment on Child Growth in Thai Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

Preliminary Investigation of Association between Methylphenidate and Serum Growth Markers in Children with Attention-Deficit/Hyperactivity Disorder: A Cross-Sectional Case-Control Study

Stimulants Do Not Increase the Risk of Seizure-Related Hospitalizations in Children with Epilepsy

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