Effects of Methylphenidate on Cognitive Functions in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: Evidence from a Systematic Review and a Meta-Analysis

Coghill, David; Seth, Sarah; Pedroso, Sara; Usala, T.; Currie, J. P.; Gagliano, Antonella

doi:10.1016/j.biopsych.2013.10.005

Cited by 234 publications

(203 citation statements)

References 95 publications

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“…With regard to prospective memory, a difference between patient groups of medium size was only revealed by the planning task, supporting the notion that in particular measures related to attention/executive functions are sensitive to the effects of MPH on cognition of patients with ADHD. This notion is also supported by findings of previous research showing that pharmacological treatment with MPH resulted in substantial improvements of attention and planning skills of adults with ADHD (Coghill et al, 2013;Tucha, Prell, et al, 2006;Turner et al, 2005). It still remains unsolved why considerably smaller effects were found on measures of memory as compared to measures of attention/executive functions.…”

Section: Discussionsupporting

confidence: 67%

“…Wigal et al, 1999). A large number of studies on adults with ADHD reported positive effects of MPH on several aspects of cognition, including alertness, vigilance, selective attention, divided attention, working memory, response inhibition, and flexibility (Aron, Dowson, Sahakian, & Robbins, 2003;Coghill et al, 2013;O. Tucha, Mecklinger et al, 2006, L. Tucha et al, 2011Turner, Blackwell, Dowson, McLean, & Sahakian, 2005).…”

mentioning

confidence: 99%

“…Given theoretical models describing ADHD as disorder of executive control (Barkley, 1997;Castellanos et al, 2006), and based on previous research revealing memory impairments in adults with ADHD (e.g., Altgassen, Koch, et al, 2014;Fuermaier, Tucha, Koerts, Aschenbrenner, Westermann, et al, 2013;Pollak et al, 2008;Seidman et al, 1998), it was expected that (a) adults with ADHD not-treated with MPH showed impaired memory functions when compared to healthy individuals, with the largest effect sizes expected in memory functions which required high demands on executive control, i.e., free recall of information (compared to word recognition), source memory and prospective memory. Furthermore, given the conclusive findings demonstrating that MPH effectively improves symptoms, cognition and functioning of adults with ADHD (e.g., Coghill et al, 2013;Vidal-Estrada et al, 2012;S. B. Wigal, 2009), it was hypothesized that (b) adults with ADHD treated with MPH showed improved memory performance compared to patients not-treated with MPH.…”

mentioning

confidence: 99%

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Effects of methylphenidate on memory functions of adults with ADHD

Fuermaier

Tucha

Koerts

et al. 2016

Applied Neuropsychology: Adult

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Section: Discussionsupporting

confidence: 67%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of methylphenidate on memory functions of adults with ADHD

Fuermaier

Tucha

Koerts

et al. 2016

Applied Neuropsychology: Adult

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“…Stimulants are clinically effective in reducing ADHD symptoms in the short-and medium term [7,8]. Moreover, there is evidence that its benefits extend to improvements in cognition relevant for academic performance [9].…”

Section: Introductionmentioning

confidence: 99%

Does methylphenidate improve academic performance? A systematic review and meta-analysis

Kortekaas-Rijlaarsdam

Luman

Sonuga‐Barke

et al. 2018

Eur Child Adolesc Psychiatry

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Academic improvement is amongst the most common treatment targets when prescribing stimulants to children with ADHD. Previous reviews on stimulant-related academic improvements are inconclusive and focus on task engagement. Recent literature suggests outcome-domain-specific medication effects that are larger for productivity than for accuracy. The aims of this study are quantifying methylphenidate effects on academic productivity and accuracy for math, reading, spelling; exploring the mediating or moderating effects of symptom improvements, demographic-, design-and disorder-related variables. PubMed, EMBASE, ERIC and PsycINFO were searched for articles reporting methylphenidate effects on academic productivity and accuracy. Thirty-four studies met entry criteria. Methylphenidate improved math productivity (7.8% increase, p < .001); math accuracy (3.0% increase, p = .001); increased reading speed (SMD .47, p < .001) but not reading accuracy. None of the mediators or moderators tested affected methylphenidate efficacy. Academic improvements were small compared to symptom improvements; qualitative changes limited to math. Clinicians should take this discrepancy into account when prescribing medication for ADHD.

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“…Methylphenidate (MPH), a catecholamine reuptake inhibitor, improves impaired inhibition in patients (Coghill et al, 2014) and enhances cognitive performance in healthy subjects (Linssen et al, 2014). MPH indirectly elevates extracellular concentrations of DA levels in striatal (Volkow et al, 1994) and extrastriatal (Montgomery et al, 2007) regions by blockage of DA transporters (DAT), while additionally blocking noradrenaline transporters.…”

Section: Introductionmentioning

confidence: 99%

Methylphenidate Effects on Brain Activity as a Function of SLC6A3 Genotype and Striatal Dopamine Transporter Availability

Kasparbauer

Rujescu²,

Riedel

et al. 2014

Neuropsychopharmacol

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We pharmacologically challenged catecholamine reuptake, using methylphenidate, to investigate its effects on brain activity during a motor response inhibition task as a function of the 3 0 -UTR variable number of tandem repeats (VNTR) polymorphism of the dopamine transporter (DAT) gene (SLC6A3) and the availability of DATs in the striatum. We measured the cerebral hemodynamic response of 50 healthy males during a Go/No-Go task, a measure of cognitive control, under the influence of 40 mg methylphenidate and placebo using 3T functional magnetic resonance imaging. Subjects were grouped into 9-repeat (9R) carriers and 10/10 homozygotes on the basis of the SLC6A3 VNTR. During successful no-go trials compared with oddball trials, methylphenidate induced an increase of blood oxygen level-dependent (BOLD) signal for carriers of the SLC6A3 9R allele but a decrease in 10/10 homozygotes in a thalamocortical network. The same pattern was observed in caudate and inferior frontal gyrus when successful no-go trials were compared with successful go trials. We additionally investigated in a subset of 35 participants whether baseline striatal DAT availability, ascertained with 123 I-FP-CIT single photon emission computed tomography, predicted the amount of methylphenidate-induced change in hemodynamic response or behavior. Striatal DAT availability was nominally greater in 9R carriers compared with 10/10 homozygotes (d ¼ 0.40), in line with metaanalyses, but did not predict BOLD or behavioral changes following MPH administration. We conclude that the effects of acute MPH administration on brain activation are dependent on DAT genotype, with 9R carriers showing enhanced BOLD following administration of a prodopaminergic compound.

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Effects of Methylphenidate on Cognitive Functions in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: Evidence from a Systematic Review and a Meta-Analysis

Cited by 234 publications

References 95 publications

Effects of methylphenidate on memory functions of adults with ADHD

Effects of methylphenidate on memory functions of adults with ADHD

Does methylphenidate improve academic performance? A systematic review and meta-analysis

Methylphenidate Effects on Brain Activity as a Function of SLC6A3 Genotype and Striatal Dopamine Transporter Availability

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