Effects of methylphenidate on responses to novelty in a teleost fish (Poecilia reticulata)

Serrano, Alex R. De; Fong, Charmaine; Rodd, F. Helen

doi:10.1016/j.bbr.2016.01.021

Cited by 12 publications

(5 citation statements)

References 54 publications

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“…Locomotor parameters (mean speed, path efficiency, and travelled distance) in this study were not altered by MPH exposure when compared to those of control fish. Changes in anxiety phenotype and the absence of MPH-induced locomotor effects have been previously reported [17,18].…”

Section: Discussionmentioning

confidence: 92%

“…Our hypothesis to explain the effects of MPH on cortisol response is based on the action of MPH in the Central Nervous System (CNS). We hypothesize that these effects might be related to increasing extracellular dopamine through dopamine release and inhibition of dopamine reuptake [3,16,17]. Additionally, MPH blocks noradrenaline and serotonergic transporters with lower affinity than that for the dopamine transporter [18].…”

Section: Discussionmentioning

confidence: 97%

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First evidence that waterborne methylphenidate alters endocrine and behavioral stress responses in zebrafish

Endres

Rosa

Kalala

et al. 2017

Neuroscience Letters

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 97%

First evidence that waterborne methylphenidate alters endocrine and behavioral stress responses in zebrafish

Endres

Rosa

Kalala

et al. 2017

Neuroscience Letters

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“…Future ecotoxicological studies on methylphenidate using fish should carefully plan dosing and endpoint measurement considering compound degradation in the water column and rapid uptake in tissues. Studies to date, for example, Endres et al ( 2017 ) and De Serrano et al ( 2016 ), exposed fish for less than an hour and then measured physiological or behavioural endpoints. Our findings indicate that methylphenidate concentrations stay above ~ 180 ng/L (the concentration that Endres et al ( 2017 ) found increased on zebrafish cortisol) in the water column for up to 2 days.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Endres et al ( 2017 ) showed that exposure to environmentally relevant concentrations of methylphenidate reduced cortisol (i.e., stress) and inhibited anxiety-like behaviours (e.g., freezing, hiding) in stressed zebrafish ( Danio rerio ). Reductions in anxiety behaviours have been noted in adult guppies ( Poecilia reticulata ) exposed to 250 ng/L (De Serrano et al 2016 ) and in zebrafish exposed to a much higher concentration (50 mg/L) as embryos (Levin et al 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Stability and uptake of methylphenidate and ritalinic acid in nine-spine stickleback (Pungitius pungitius) and water louse (Asellus aquaticus)

McCallum

Lindberg

Andersson

et al. 2019

Environ Sci Pollut Res

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The presence of human pharmaceuticals in the environment has garnered significant research attention because these compounds may exert therapeutic effects on exposed wildlife. Yet, for many compounds, there is still little research documenting their stability in the water column and uptake in organism tissues. Here, we measured the uptake and stability of methylphenidate (Ritalin®, a frequently prescribed central nervous system stimulant) and its primary metabolite, ritalinic acid, in (1) water only or (2) with nine-spine stickleback and water louse. Methylphenidate degraded to ritalinic acid in both studies faster at a higher temperature (20 °C versus 10 °C), with concentrations of ritalinic acid surpassing methylphenidate after 48–100 h, depending on temperature. The concentration of methylphenidate in stickleback was highest at the first sampling point (60 min), while the concentration in water louse tissues reached comparatively higher levels and peaked after ~ 6 days. Neither stickleback nor water louse took up ritalinic acid in tissues despite being present in the water column. Our findings provide valuable data for use in future risk assessment of methylphenidate and will aid in the design of studies aimed at measuring any ecotoxicological effects on, for example, the behaviour or physiology of aquatic organisms. Electronic supplementary material The online version of this article (10.1007/s11356-019-04557-9) contains supplementary material, which is available to authorized users.

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“…D 1 -class receptors are expressed more widely in the brain compared to the D 2 -class and both are present postsynaptically [4,5]. D 1 and D 2 receptors have been reported in zebrafish [6,7], and the dopaminergic system is known to partially regulate reward, motivation, sociality and response to novelty in teleost fish [8][9][10][11][12][13][14]. Additionally, the administration of D 1 receptor agonists has recently been shown to enhance learning based tasks in cleaner wrasse (Labroides Dimidiatus) [2] and zebrafish [15].…”

Section: Introductionmentioning

confidence: 99%

Dopamine D1 receptor activation leads to object recognition memory in a coral reef fish

2017

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Object recognition memory is the ability to identify previously seen objects and is an adaptive mechanism that increases survival for many species throughout the animal kingdom. Previously believed to be possessed by only the highest order mammals, it is now becoming clear that fish are also capable of this type of memory formation. Similar to the mammalian hippocampus, the dorsolateral pallium regulates distinct memory processes and is modulated by neurotransmitters such as dopamine. Caribbean bicolour damselfish () live in complex environments dominated by coral reef structures and thus likely possess many types of complex memory abilities including object recognition. This study used a novel object recognition test in which fish were first presented two identical objects, then after a retention interval of 10 min with no objects, the fish were presented with a novel object and one of the objects they had previously encountered in the first trial. We demonstrate that the dopamine D-receptor agonist (SKF 38393) induces the formation of object recognition memories in these fish. Thus, our results suggest that dopamine-receptor mediated enhancement of spatial memory formation in fish represents an evolutionarily conserved mechanism in vertebrates.

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Effects of methylphenidate on responses to novelty in a teleost fish (Poecilia reticulata)

Cited by 12 publications

References 54 publications

First evidence that waterborne methylphenidate alters endocrine and behavioral stress responses in zebrafish

First evidence that waterborne methylphenidate alters endocrine and behavioral stress responses in zebrafish

Stability and uptake of methylphenidate and ritalinic acid in nine-spine stickleback (Pungitius pungitius) and water louse (Asellus aquaticus)

Dopamine D1 receptor activation leads to object recognition memory in a coral reef fish

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