Effects of methylphenidate on sensory and sensorimotor gating of initially psychostimulant-naïve adult ADHD patients

Sommer, Julijana le; Low, Ann-Marie; Jepsen, Jens Richardt Møllegaard; Fagerlund, Birgitte; Vangkilde, Signe; Habekost, Thomas; Glenthøj, Birte; Oranje, Bob

doi:10.1016/j.euroneuro.2021.02.004

Cited by 7 publications

(1 citation statement)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Instead, male SLC7A11 sut/sut mice displayed other behavioral phenotypes including a lower efficiency in sensory filtering, heightened anxiety, sensitization, and impaired spatial learning when young, along with emerging hyperactivity in adulthood. These behavioral traits are commonly associated with attention deficit hyperactivity disorder (ADHD) in ADHD mouse models ( Jhang et al, 2017 ; Custodio et al, 2021 ) as well as in individuals with ADHD ( Reimherr et al, 2017 ; Sommer et al, 2021 ). Interestingly, the observation of hyperactivity found exclusively in male SLC7A11 sut/sut mice aligns with the predominance of hyperactivity in male individuals diagnosed with ADHD ( Williamson and Johnston, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Sex- and age-dependent contribution of System xc– to cognitive, sensory, and social behaviors revealed by comprehensive behavioral analyses of System xc– null mice

Frare

Pitt

Hewett

2023

Front. Behav. Neurosci.

View full text Add to dashboard Cite

BackgroundSystem xc– (Sxc–) is an important heteromeric amino acid cystine/glutamate exchanger that plays a pivotal role in the CNS by importing cystine into cells while exporting glutamate. Although certain behaviors have been identified as altered in Sxc– null mutant mice, our understanding of the comprehensive impact of Sxc– on behavior remains incomplete.MethodsTo address this gap, we compared motor, sensory and social behaviors of male and female mice in mice null for Sxc– (SLC7A11sut/sut) with wildtype littermates (SLC7A11+/+) in a comprehensive and systematic manner to determine effects of genotype, sex, age, and their potential interactions.ResultsMotor performance was not affected by loss of Sxc– in both males and females, although it was impacted negatively by age. Motor learning was specifically disrupted in female mice lacking Sxc– at both 2 and 6 months of age. Further, female SLC7A11sut/sut mice at both ages exhibited impaired sociability, but normal spatial and recognition memory, as well as sensorimotor gating. Finally, pronounced open-space anxiety was displayed by female SLC7A11sut/sut when they were young. In contrast, young SLC7A11sut/sut male mice demonstrated normal sociability, delayed spatial learning, increased open-space anxiety and heightened sensitivity to noise. As they aged, anxiety and noise sensitivity abated but hyperactivity emerged.DiscussionWe find that the behavioral phenotypes of female SLC7A11sut/sut are similar to those observed in mouse models of autism spectrum disorder, while behaviors of male SLC7A11sut/sut resemble those seen in mouse models of attention deficit hyperactivity disorder. These results underscore the need for further investigation of SLC7A11 in neurodevelopment. By expanding our understanding of the potential involvement of Sxc–, we may gain additional insights into the mechanisms underlying complex neurodevelopmental conditions.

show abstract