Effects of Methylphenidate on the Inhibitory Postsynaptic Potential in Rat Locus Coeruleus Neurons.

Kuwahata, Takashi; Ishimatsu, Masaru; Kidani, Yuri; Akasu, Takashi

doi:10.2739/kurumemedj.49.185

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…Das strukturchemisch mit dem Amphetamin verwandte und wie dieses dem Betäubungsmittelgesetz unterliegende Methylphenidat entfaltet seine stimulierende, indirekt sympathomimetische Wirkung über die präsynaptische Rückaufnahme-hemmung von Dopamin und vermutlich auch von Noradrenalin [34,60]. Methylphenidat zeigt eine dem Kokain vergleichbare Affinität zum Dopamintransporter [50].…”

Section: Methylphenidatunclassified

Neue Entwicklungen in der Pharmakotherapie der Kokainabhängigkeit

Wiesbeck

Dürsteler‐MacFarland

2006

Nervenarzt

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New possibilities with medications for the treatment of cocaine dependence have begun to emerge. For example, in a randomised controlled study, disulfiram succeeded for the first time in significantly reducing cocaine consumption. In October 2003, a phase IIb study was started in the USA testing active immunisation against cocaine dependence. There is also an ongoing study in Switzerland testing methylphenidate treatment in combination with cognitive behavioural therapy. Pilot studies indicate that vigabatrin, selegiline, and topiramate are promising candidates for further clinical substance testing.

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Section: Methylphenidatunclassified

Neue Entwicklungen in der Pharmakotherapie der Kokainabhängigkeit

Wiesbeck

Dürsteler‐MacFarland

2006

Nervenarzt

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Acute and sub-chronic functional neurotoxicity of methylphenidate on neural networks in vitro

2007

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Methylphenidate (MPH) is the drug of choice in the treatment of attention deficit and hyperactivity disorders. Although a popular drug, concentration-dependent electrophysiological alteration or impairment (functional toxicity) and reversibility, have not been quantified. This study used spontaneously active neuronal networks growing on microelectrode arrays (MEA) to investigate functional neurotoxicity of MPH by assessing its acute and sub-chronic electrophysiologic effects on auditory cortex networks (ACN) and frontal cortex networks (FCN) at concentrations that reflect clinical doses and overdoses. Acute exposure to 1-300 microM MPH induced concentration-dependent inhibition of spontaneous activity with spike rate IC(50) values (concentration inducing 50% inhibition) of 112.9 +/- 18.6 and 108.0 +/- 18.9 microM for ACNs and FCNs respectively. Sub-chronic exposure to 1 mM MPH for 24 h blocked all activity followed by partial spontaneous recovery after 15 h. Tyrosine hydroxylase immunocytochemistry analysis indicated positive staining of neurons, confirming the presence of catecholaminergic neurons in cultured cortex networks.

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Methylphenidate (MPH) promotes visual cortical activation in healthy adults in a cued visuomotor task

et al. 2012

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Seeking for the mechanisms by which methylphenidate (MPH) improves behavior has demonstrated that MPH modulates excitability in the primary motor cortex. However, little is known about the influence of MPH on top-down controlled mechanisms in the sensory domain. The present study explored the effects of MPH on the activation of visual cortices in healthy adults who performed a cued visuo-motor task in a double-blind placebo-controlled crossover design. Two distinct measures, posterior alpha power and occipital slow cortical potentials (SCPs), were used to reflect raise in excitability and attention-based activation of visual cortical areas. According to the results, performance parameters (reaction time, response variance and error rate) were not affected by MPH. At the neurophysiologic level reflected by reduced alpha power, MPH increased the overall excitability of the occipital cortex, but not the parietal cortex. Before the cued response, MPH reduced alpha power and increased SCPs only before right hand responses, mostly at the right occipital location. It can be concluded that in visuo-motor tasks, MPH has the potency of adjusting the background excitation/inhibition balance of visual areas. Additionally, MPH may raise the attention controlled activation of visual cortical regions, especially during increased response control.

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Effects of Methylphenidate on the Inhibitory Postsynaptic Potential in Rat Locus Coeruleus Neurons.

Cited by 5 publications

References 16 publications

Neue Entwicklungen in der Pharmakotherapie der Kokainabhängigkeit

Neue Entwicklungen in der Pharmakotherapie der Kokainabhängigkeit

Acute and sub-chronic functional neurotoxicity of methylphenidate on neural networks in vitro

Methylphenidate (MPH) promotes visual cortical activation in healthy adults in a cued visuomotor task

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