Effects of methylprednisolone and dextromethorphan on lipid peroxidation in an experimental model of spinal cord injury

Abstract

Methylprednisolone was able to keep the levels for all parameters close to baseline except for 30-min MDA, MDA(b), and SOD values. But their results were all different from those of G3. Dextromethorphan was successful in this respect at 30-min GSH-Px and 120-min SOD and GSH-Px, and all values were also different from G3 values except for 10-min MDA, SOD, and GSH-Px. Combined therapy was not able to keep levels close to baseline for all parameters, but they were different from G3's except for the GSH-Px values. Methylprednisolone values displayed minimal alterations according to baseline at 120 min. Dextromethorphan was relatively unsuccessful at 10 min. Combined therapy did not show benefit superior to MP/DM single therapies.

Duration of lipid peroxidation after acute spinal cord injury in rats and the effect of methylprednisolone

“…23 These measurements were primarily taken within the first few hours after injury [21][22][23]45 and correlate well with the reduction in levels we observed in the first peak. However, neither short-term (24-hour) nor continuous infusion of methylprednisolone had any effect on the second MDA peak observed in this study.…”

“…44 Although the pathological changes such as the development of a gliotic scar around the lesion, 44 wallerian degeneration, axonal loss, 16 and prolonged ischemia 2 are well characterized, the time course and magnitude of lipid peroxidation are not known beyond the initial 24 hours after the injury as the majority of studies on lipid peroxidation have measured markers only within the first 24 hours after injury. 4,7,21,39,42,43,45 Establishing the duration of lipid peroxidation after the injury is important as reduction of lipid peroxidation with drugs such as methylprednisolone has been proposed as a potential therapeutic intervention in patients who have suffered SCI.…”

Three-Year Experience in the Emergency Department: The Emergency Department Approach to the Patients with Spinal Trauma and Prognosis

“…[6] Methylprednisolone infusion improves motor and sensory recovery in complete and incomplete spinal cord injuries. However, this expected positive result is based on using the steroid at the proper time and proper dose.…”

“…[5] Methylprednisolone is suggested to be beneficial because it is a radical scavenger, prevents lipid peroxidation and has neuroprotective effects. [6] The incidence of complete spinal cord injuries has decreased depending on such actions as timely and properly rendered first aid, more favorable resuscitation, and the fastening of seat belts. All these factors positively influence the recovery process.…”

Management of spinal trauma in emergency department

“…The effect of methylprednisolone in reducing spinal cord damage is considered to depend on many mechanisms. These are inhibition of lipid peroxidation, prevention of progressive post-traumatic ischemia through the regulation of tissue blood flow and aerobic energy metabolism, inhibition of neurofilament degradation, prevention of intracellular calcium accumulation, inhibition of prostaglandin F2-alpha and thromboxane A2 formation, and reduction of spinal neuronal excitability (Dumont et al, 2001;Topsakal et al, 2002).…”